Placenta
Volume 16, Issue 1 , Pages 75-83, January 1995

In vitro effect of antiphospholipid antibody-containing sera on basal and gonadotrophin releasing hormonedependent human chorionic gonadotrophin release by cultured trophoblast cells

  • N. Di Simone

      Affiliations

    • Department of Obstetrics and Gynecology, Universita' Cattolica S. Cuore, Largo Gemelli 8, 00168 Rome, Italy
    • ,
  • S. De Carolis

      Affiliations

    • Department of Obstetrics and Gynecology, Universita' Cattolica S. Cuore, Largo Gemelli 8, 00168 Rome, Italy
    • ,
  • A. Lanzone

      Affiliations

    • Oasi, Institute of Research, Troina, Italy
    • ,
  • E. Ronsisvalle

      Affiliations

    • Department of Obstetrics and Gynecology, Universita' Cattolica S. Cuore, Largo Gemelli 8, 00168 Rome, Italy
    • ,
  • R. Giannice

      Affiliations

    • Department of Obstetrics and Gynecology, Universita' Cattolica S. Cuore, Largo Gemelli 8, 00168 Rome, Italy
    • ,
  • A. Caruso

      Affiliations

    • Corresponding Author InformationTo whom correspondence should be addressed
    • Department of Obstetrics and Gynecology, Universita' Cattolica S. Cuore, Largo Gemelli 8, 00168 Rome, Italy

Accepted 9 August 1994.

Abstract 

Our objective was to evaluate whether antiphospholipid antibody-containing sera could play a regulatory role in signal transduction induced by gonadotrophin releasing hormone (GnRH) when incubated with normal human trophoblast cells. To test this hypothesis we established an in vitro placental culture system in which GnRH addition in the presence of normal human serum resulted in a significant increase in human chorionic gonadotrophin (hCG) secretion. When GnRH was added to the culture medium with antiphospholipid antibody-containing sera, the hCG increase was inhibited. These results suggest the possibility that anti-phospholipid antibody positive sera can exert their effect on GnRH-induced signal transduction. Further studies are needed to explain their exact site of action.

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PII: 0143-4004(95)90083-7

Placenta
Volume 16, Issue 1 , Pages 75-83, January 1995

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