Placenta
Volume 28, Issue 2 , Pages 85-96 , February 2007

Carcinoembryonic Antigen and Related Molecules in Normal and Transformed Trophoblast

,Accepted 7 February 2006.

References 

  1. Finkenzeller D, Fischer B, Lutz S, Schrewe H, Shimizu T, Zimmermann W. Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development. Mol Cell Biol. 2003;23:272–279
  2. Thomas P, Toth CA, Saini KS, Jessup JM, Steele G. The structure, metabolism and function of the carcinoembryonic antigen gene family. Biochim Biophys Acta. 1990;1032:177–189
  3. Egawa K, Honda Y, Ono T, Kitasato H, Kuroki M. The glycoprotein of the carcinoembryonic antigen (CEA) gene family expressed on epithelial keratinocytes in viral warts. Arch Dermatol Res. 1998;290:453–457
  4. Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, et al. Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res. 1999;252:243–249
  5. Olsen A, Teglund S, Nelson D, Gordon L, Copeland A, Georgescu A, et al. Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region. Genomics. 1994;23:659–668
  6. Öbrink B. CEA adhesion molecules: multifunctional proteins with signal-regulatory properties. Curr Opin Cell Biol. 1997;9:616–626
  7. Finkenzeller D, Fischer B, McLaughlin J, Schrewe H, Ledermann B, Zimmermann W. Trophoblast cell-specific carcinoembryonic antigen cell adhesion molecule 9 is not required for placental development or a positive outcome of allotypic pregnancies. Mol Cell Biol. 2000;20:7140–7145
  8. Thompson JA, Grunert F, Zimmermann W. Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal. 1991;5:344–366
  9. Thompson JA. Molecular cloning and expression of carcinoembryonic antigen gene family members. Tumor Biol. 1995;16:10–16
  10. Zhou GQ, Baranov V, Zimmermann W, Grunert F, Erhard B, Mincheva-Nilsson L, et al. Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta. Placenta. 1997;18:491–501
  11. Chou JY, Sartwell AD, Wan Y-JY, Watanabe S. Characterization of pregnancy-specific β1-glycoprotein synthesized by human placental fibroblasts. Mol Endocrinol. 1989;3:89–96
  12. Frank HG, Kaufmann P. Nonvillous parts and trophoblast invasion. In:  Benirschke K,  Kaufmann P editor. Pathology of the human placenta. New York, Berlin, Heidelberg: Springer-Verlag; 2000;p. 171–272
  13. Bamberger AM, Sudahl S, Loning T, Wagener C, Bamberger CM, Drakakis P, et al. The adhesion molecule CEACAM1 (CD66a, C-CAM, BGP) is specifically expressed by the extravillous intermediate trophoblast. Am J Pathol. 2000;156:1165–1170
  14. Briese J, Oberndorfer M, Patschenik C, Schlte HM, Makrigiannakis A, Loning T, et al. Osteopontin (OPN) is colocalized with the adhesion molecule CEACAM1 in the extravillous trophoblast of the human placenta and enhances invasion of CEACAM1-expressing placental cells. J Clin Endocrinol Metab. 2005;
  15. Benirschke K, Kaufmann P. Trophoblastic neoplasm. In:  Benirschke K,  Kaufmann P editor. Pathology of the human placenta. New York, Berlin, Heidelberg: Springer-Verlag; 2000;p. 754–778
  16. Bamberger AM, Sudahl S, Wagener C, Loning T. Expression pattern of the adhesion molecule CEACAM1 (C-CAM, CD66a, BGP) in gestational trophoblast lesions. Int J Gynecol Pathol. 2001;20:160–165
  17. Leslie KK, Watanabe S, Lei KJ, Chou DY, Plouzek CA, Deng HC, et al. Linkage of two human pregnancy specific b1 glycoprotein genes: one is associated with hydatiform mole. Proc Natl Acad Sci U S A. 1990;87:5822–5826
  18. Hammarstrom S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999;9:67–81
  19. Golubović S. Immunometric and lectin assays for quantitation and determination of tumor markers chorionic gonadotropin and carcinoembryonic antigen. M.Sc. thesis. University of Belgrade; 1996.
  20. Božić M, Petronijević M, Milenković S, Atanacković J, Lazić J, Vićovac Lj. Galectin-1 and galectin-3 in the trophoblast of the gestational trophoblastic disease. Placenta. 2004;25:797–802
  21. Laemli UK. Cleveage of structural proteins during the assembly of the head of the bacteriophage T4. Nature. 1970;227:680–685
  22. Beeley JA, Sweeney D, Linndsay JCB, Buchanan ML, Sarka L, Khoo KS. Sodium dodecyl sulphate-polyacrylamide electrophoresis of human parotid salivary proteins. Electrophoresis. 1991;12:1032–1041
  23. Tatarinov YS. A new placental protein test for the presence and identification of trophoblast tumors. Antibiot Chemother. 1978;22:125–131
  24. Bollag DM, Edelstein SJ. Immunoblotting. In:  Bollag DM,  Edelstein SJ editor. Protein methods. New York, Chichester, Brisbane, Toronto, Singapore: John Wiley & Sons, Inc.; 1991;p. 181–208
  25. Aronow BJ, Richardson BD, Handwerger S. Microarray analysis of trophoblast differentiation: gene expression reprogramming in key gene function categories. Physiol Genomics. 2001;6:105–116
  26. Ilantzis C, De Marte L, Screaton RA, Stanners CP. Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia. 2002;4:151–163
  27. Duxbury MS, Zinner MJ, Ashley SW, Whang EE. CEACAM6 gene silence impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene. 2004;15:465–473
  28. Ordonez C, Screaton RA, Ilantzis C, Stanners CP. Human carcinoembryonic antigen functions as general inhibitor of anoikis. Cancer Res. 2000;60:3419–3424
  29. Leusch HG, Drzeniek Z, Markos-Pusztai Z. Binding of Escherichia coli and Salmonella strains to member of the carcinoembryonic antigen family: differential binding inhibition by aromatic alpha-glycosydes of mannose. Infect Immun. 1991;59:2051–2057
  30. Virji M, Makepeace K, Ferguson DJP, Watt SM. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae. Mol Microbiol. 1996;22:941–950
  31. Muenzner P, Dehio C, Fujiwara T, Achtman M, Meyer TF, Gray-Owen SD. Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflamatory cytokine-activated endothelial cells. Infect Immun. 2000;68:3601–3607
  32. Grudzinska JG, Evans DG, Gordon YB, Jeffrey D, Chard T. Pregnancy specific beta 1 glycoprotein in fetal and maternal compartments. Obstet Gynecol. 1978;52:43–45
  33. Watanabe S, Chou JY. Human pregnancy-specific β1-glycoprotein: a new member of the carcinoembryonic antigen gene family. Biochem Biophys Res Commun. 1988;152:762–768
  34. Mora J, Queralto JM. Within-subject variation of carcinoembryonic antigen in colorectal cancer-application of reference change values and individual reference change values and individual reference ranges to patient follow-up. Eur J Chem Clin Biochem. 1997;35:453–457
  35. King J, Caplehorn JRM, Ross WB, Morris DL. High serum carcinoembryonic antigen concentration in patients with colorectal liver metastases is associated with poor cell-mediated immunity, which is predictive of survival. Br J Surg. 1997;84:1382–1385
  36. Grem JL, Steinberg SM, Chen AP, McAtee N, Cullen E, Hamilton JM, et al. The utility of monitoring carcinoembryonic antigen during systemic therapy for advanced colorectal cancer. Oncol Rep. 1998;5:559–567
  37. Kim DY, Kim HR, Shim JH, Park CS, Kim SK, Jin YMD. Significance of serum and tissue carcinoembryonic antigen for the prognosis of gastric carcinoma patients. J Surg Oncol. 2000;74:185–192
  38. Ohannesian DW, Lotan D, Thomas P, Jessup JM, Fukuda M, Gabius HJ, et al. Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells. Cancer Res. 1995;55:2191–2199
  39. Ohannesian DW, Lotan R. Galectins in tumor cells. In:  Gabius HJ,  Gabiu S editor. Glycosciences status and perspectives. Weinheim: Chapman & Hall GmbH; 1997;p. 459–469
  40. Cvejic D, Savin S, Golubovic S, Paunovic I, Tatic S, Havelka M. Galectin-3 and carcinoembryonic antigen expression in medullary thyroid carcinoma: possible relation to tumour progression. Histopathology. 2000;37:530–535
  41. DiSaia PJ, Haverback BJ, Dyce BJ, Morrow CP. Carcinoembryonic antigen in patients with gynecologic malignancies. Am J Obstet Gynecol. 1975;121:159–163
  42. Varma R, Mayor S. GPI-anchored proteins are organized in submicron domains at the cell surface. Nature. 1998;394:798–801
  43. Ordonez C, Screaton RA, Ilantzis C, Stanners CP. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res. 2000;60:3419–3424

PII: S0143-4004(06)00032-4

doi: 10.1016/j.placenta.2006.02.002

Placenta
Volume 28, Issue 2 , Pages 85-96 , February 2007

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