Placenta
Volume 28, Issue 2 , Pages 152-160 , February 2007

Human LBP-32/MGR is a Repressor of the P450scc in Human Choriocarcinoma Cell Line JEG-3

  • Y.C. Henderson

      Affiliations

    • Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • M.J. Frederick

      Affiliations

    • Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • A. Jayakumar

      Affiliations

    • Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Y. Choi

      Affiliations

    • The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
  • ,
  • M.T. Wang

      Affiliations

    • Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • Y. Kang

      Affiliations

    • Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • R. Evans

      Affiliations

    • Department of Blood and Marrow Transplantation, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
  • ,
  • P.M. Spring

      Affiliations

    • Department of Otolaryngology-Head & Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
  • ,
  • M. Uesugi

      Affiliations

    • The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
  • ,
  • G.L. Clayman

      Affiliations

    • Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    • Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. Department of Head & Neck Surgery, Unit 441, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. Tel.: +1 713 792 6920; fax: +1 713 794 4662.

,Accepted 8 March 2006.

References 

  1. Moore CC, Hum DW, Miller WL. Identification of positive and negative placenta-specific basal elements and a cyclic adenosine 3′, 5′-monophosphate response element in the human gene for P450scc. Mol Endocrinol. 1992;6:2045–2058
  2. Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proc Natl Acad Sci U S A. 1986;83:8962–8966
  3. Hum DW, Aza-Blanc P, Miller WL. Characterization of placental transcriptional activation of the human gene for P450scc. DNA Cell Biol. 1995;14:451–463
  4. Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, et al. Steroidogenic factor 1: an essential mediator of endocrine development. [Review; 73 refs] Recent Prog Horm Res. 2002;57:19–36
  5. Ramayya MS, Zhou J, Kino T, Segars JH, Bondy CA, Chrousos GP. Steroidogenic factor 1 messenger ribonucleic acid expression in steroidogenic and nonsteroidogenic human tissues: northern blot and in situ hybridization studies. J Clin Endocrinol Metab. 1997;82:1799–1806
  6. Ben Zimra M, Koler M, Orly J. Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element. Mol Endocrinol. 2002;16:1864–1880
  7. Ben Zimra M, Koler M, Melamed-Book N, Arensburg J, Payne AH, Orly J. Uterine and placental expression of steroidogenic genes during rodent pregnancy. [Review; 73 refs] Mol Cell Endocrinol. 2002;187:223–231
  8. Knofler M, Vasicek R, Schreiber M. Key regulatory transcription factors involved in placental trophoblast development – a review. [Review; 82 refs] Placenta. 2001;22(Suppl. A):S83–S92
  9. Huang N, Miller WL. Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc. J Biol Chem. 2000;275:2852–2858
  10. Gizard F, Lavallee B, DeWitte F, Hum DW. A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression. J Biol Chem. 2001;276:33881–33892
  11. Wilanowski T, Tuckfield A, Cerruti L, O'Connell S, Saint R, Parekh V, et al. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev. 2002;114:37–50
  12. Bray SJ, Burke B, Brown NH, Hirsh J. Embryonic expression pattern of a family of Drosophila proteins that interact with a central nervous system regulatory element. Genes Dev. 1989;3:1130–1145
  13. Dynlacht BD, Attardi LD, Admon A, Freeman M, Tjian R. Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements. Genes Dev. 1989;3:1677–1688
  14. Okazaki Y, Shizuri Y. Structures of six cDNAs expressed specifically at cypris larvae of barnacles, Balanus amphitrite. Gene. 2000;250:127–135
  15. Lim LC, Swendeman SL, Sheffery M. Molecular cloning of the alpha-globin transcription factor CP2. Mol Cell Biol. 1992;12:828–835
  16. Ramamurthy L, Barbour V, Tuckfield A, Clouston DR, Topham D, Cunningham JM, et al. Targeted disruption of the CP2 gene, a member of the NTF family of transcription factors. J Biol Chem. 2001;276:7836–7842
  17. Uv AE, Thompson CR, Bray SJ. The Drosophila tissue-specific factor grainyhead contains novel DNA-binding and dimerization domains which are conserved in the human protein CP2. Mol Cell Biol. 1994;14:4020–4031
  18. Kohler PO, Bridson WE. Isolation of hormone-producing clonal lines of human choriocarcinoma. J Clin Endocrinol Metab. 1971;32:683–687
  19. Ringler GE, Strauss JF. In vitro systems for the study of human placental endocrine function. [Review; 190 refs] Endocr Rev. 1990;11:105–123
  20. Shellenberger TD, Wang M, Gujrati M, Jayakumar A, Strieter RM, Burdick MD, et al. BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. Cancer Res. 2004;64:8262–8270
  21. Frederick MJ, Henderson Y, Xu X, Deavers MT, Sahin AA, Wu H, et al. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. Am J Pathol. 2000;156:1937–1950
  22. Henderson YC, Clayman GL. An effective method for removing ribosomal RNA during mRNA purification. Methods Cell Sci. 2000;22:253–255
  23. Smith PJ, Blunt N, Wiltshire M, Hoy T, Teesdale-Spittle P, Craven MR, et al. Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy. Cytometry. 2000;40:280–291
  24. Wiltshire M, Patterson LH, Smith PJ. A novel deep red/low infrared fluorescent flow cytometric probe, DRAQ5NO, for the discrimination of intact nucleated cells in apoptotic cell populations. Cytometry. 2000;39:217–223
  25. Henderson YC, Breau RL, Liu TJ, Clayman GL. Telomerase activity in head and neck tumors after introduction of wild-type p53, p21, p16, and E2F-1 genes by means of recombinant adenovirus. Head Neck. 2000;22:347–354
  26. Choi Y, Asada S, Uesugi M. Divergent hTAFII31-binding motifs hidden in activation domains. J Biol Chem. 2000;275:15912–15916
  27. Jayakumar A, Kang Y, Frederick MJ, Pak SC, Henderson Y, Holton PR, et al. Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys. 2003;409:367–374
  28. Sims SH, Cha Y, Romine MF, Gao PQ, Gottlieb K, Deisseroth AB. A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter. Mol Cell Biol. 1993;13:690–702
  29. Rodriguez LV, Gersten DM, Ramagli LS, Johnston DA. Towards stoichiometric silver staining of proteins resolved in complex two-dimensional electrophoresis gels: real-time analysis of pattern development. Electrophoresis. 1993;14:628–637
  30. Nordeen SK. Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques. 1988;6:454–458
  31. Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, et al. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. J Biol Chem. 2001;276:8734–8739
  32. Spring P, Nakashima T, Frederick M, Henderson Y, Clayman G. Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q. Biochem Biophys Res Commun. 1999;264:299–304
  33. Toraman AD, Keser I, Luleci G, Tunali N, Gelen T. Comparative genomic hybridization in ganglioneuroblastomas. Cancer Genet Cytogenet. 2002;132:36–40
  34. Joos S, Menz CK, Wrobel G, Siebert R, Gesk S, Ohl S, et al. Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2. Blood. 2002;99:1381–1387
  35. Huang N, Miller WL. LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells. Mol Endocrinol. 2005;19:409–420
  36. Hayashi Y, Yamagishi M, Nishimoto Y, Taguchi O, Matsukage A, Yamaguchi M. A binding site for the transcription factor grainyhead/nuclear transcription factor-1 contributes to regulation of the Drosophila proliferating cell nuclear antigen gene promoter. J Biol Chem. 1999;274:35080–35088
  37. Liaw GJ, Rudolph KM, Huang JD, Dubnicoff T, Courey AJ, Lengyel JA. The torso response element binds GAGA and NTF-1/Elf-1, and regulates tailless by relief of repression. Genes Dev. 1995;9:3163–3176
  38. Huang JD, Dubnicoff T, Liaw GJ, Bai Y, Valentine SA, Shirokawa JM, et al. Binding sites for transcription factor NTF-1/Elf-1 contribute to the ventral repression of decapentaplegic. Genes Dev. 1995;9:3177–3189

PII: S0143-4004(06)00061-0

doi: 10.1016/j.placenta.2006.03.008

Placenta
Volume 28, Issue 2 , Pages 152-160 , February 2007