Placenta
Volume 28, Issue 2 , Pages 65-76, February 2007

PPARs and the Placenta

  • T. Fournier

      Affiliations

    • INSERM, U767, 4 avenue de l'Observatoire, 75006 Paris, France
    • Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75006 Paris, France
    • ,
  • V. Tsatsaris

      Affiliations

    • INSERM, U767, 4 avenue de l'Observatoire, 75006 Paris, France
    • Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75006 Paris, France
    • Maternité Port-Royal, AP-HP, Université René Descartes, Paris 5, France
    • ,
  • K. Handschuh

      Affiliations

    • INSERM, U767, 4 avenue de l'Observatoire, 75006 Paris, France
    • Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75006 Paris, France
    • ,
  • D. Evain-Brion

      Affiliations

    • INSERM, U767, 4 avenue de l'Observatoire, 75006 Paris, France
    • Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75006 Paris, France
    • Corresponding Author InformationCorresponding author at present address: INSERM U427, Faculté de Pharmacie, 75006 Paris, France. Tel.: +33 (1) 53 73 96 00; fax: +33 (1) 44 07 39 92.

Accepted 30 April 2006. published online 11 July 2006.

Abstract 

The discovery of the peroxisome proliferator-activated receptors (PPARs) in 1990s provided new insights in understanding the mechanisms involved in the control of energy homeostasis and in cell differentiation, proliferation, apoptosis and the inflammatory process. The PPARs became thus an exciting therapeutic target for diabetes, metabolic syndrome, atherosclerosis, and cancer. Unexpectedly, genetic studies performed in mice established that PPARγ are essential for placental development. After a brief description of structural and functional features of PPARs, we will summarize in this review the most recent results concerning expression and the role of PPARs in placenta and of PPARγ in human trophoblastic cells in particular.

Keywords: PPAR, Placenta, Cytotrophoblast, Differentiation

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PII: S0143-4004(06)00120-2

doi:10.1016/j.placenta.2006.04.009

Placenta
Volume 28, Issue 2 , Pages 65-76, February 2007

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