Placenta
Volume 28, Issue 5 , Pages 557-565 , May 2007

Decidual Activation: Abundance and Localization of Prostaglandin F Receptor (FP) mRNA and Protein and Uterine Activation Proteins in Human Decidua at Preterm Birth and Term Birth

  • S. Makino

      Affiliations

    • Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
    • Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
  • ,
  • D.B. Zaragoza

      Affiliations

    • Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
    • Corresponding Author InformationCorresponding author. Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada T6G 2S2. Tel.: +1 780 492 0029; fax: +1 780 492 1308.
  • ,
  • B.F. Mitchell

      Affiliations

    • Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
  • ,
  • H. Yonemoto

      Affiliations

    • Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
  • ,
  • D.M. Olson

      Affiliations

    • Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
    • Perinatal Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Canada
    • Perinatal Research Centre, Department of Physiology, University of Alberta, Edmonton, Canada

,Accepted 20 June 2006.

References 

  1. Lye SJ, Challis JR. Paracrine and endocrine control of myometrial activity at term. In:  Gluckman P,  Johnson B,  Nathanielsz P editor. Advances in fetal physiology. New York: Perinatology Press; 1989;p. 361–375
  2. Lye SJ, Mitchell J, Nashman N, Oldenhof A, Ou R, Shynlova O, et al. Role of mechanical signals in the onset of term and preterm labor. Front Horm Res. 2001;27:165–178
  3. Challis JR, Matthews SG, Gibb W, Lye SJ. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev. 2000 Oct;21(5):514–550
  4. Olson DM. The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth?. J Soc Gynecol Investig. 2005 Oct;12(7):466–478
  5. Astle S, Thornton S, Slater DM. Identification and localization of prostaglandin E2 receptors in upper and lower segment human myometrium during pregnancy. Mol Hum Reprod. 2005 Apr;11(4):279–287
  6. Lye SJ, Olson DM. Parturition and regulation of uterine activity. In:  Gluckman P,  Heymann M editor. Pediatrics & perinatology, the scientific basis. London: Edward Arnold Publishers Ltd; 1996;p. 242–251
  7. Fuchs AR, Fuchs F, Husslein P, Soloff MS, Fernstrom MJ. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science. 1982;215:1396–1398
  8. Ulug U, Goldman S, Ben-Shlomo I, Shalev E. Matrix metalloproteinase (MMP)-2 and MMP-9 and their inhibitor, TIMP-1, in human term decidua and fetal membranes: the effect of prostaglandin F and indomethacin. Mol Hum Reprod. 2001;7:1187–1193
  9. Goldman S, Weiss A, Almalah I, Shalev E. Progesterone receptor expression in human decidua and fetal membranes before and after contractions: possible mechanism for functional progesterone withdrawal. Mol Hum Reprod. 2005 Apr;11(4):269–277
  10. Olson DM, Mijovic JE, Sadowsky DW. Control of human parturition. Semin Perinatol. 1995;19:52–63
  11. Johnson RF, Mitchell CM, Clifton V, Zakar T. Regulation of 15-hydroxyprostaglandin dehydrogenase (PGDH) gene activity, messenger ribonucleic acid processing, and protein abundance in the human chorion in late gestation and labor. J Clin Endocrinol Metab. 2004 Nov;89(11):5639–5648
  12. Okazaki T, Casey ML, Okita JR, MacDonald PC, Johnston JM. Initiation of human parturition. XII. Biosynthesis and metabolism of prostaglandins in human fetal membranes and uterine decidua. Am J Obstet Gynecol. 1981;139:373–381
  13. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45
  14. Willman EA, Collins WP. The concentrations of prostaglandin E2 and prostaglandin F2 alpha in tissues within the fetoplacental unit after spontaneous or induced labour. Br J Obstet Gynaecol. 1976;83:786–789
  15. Satoh K, Yasumizu T, Kawai Y, Ozaki A, Wu T, Kinoshita K, et al. In vitro production of prostaglandins E, F, and 6-keto prostaglandin F1 alpha by human pregnant uterus, decidua and amnion. Prostaglandins Med. 1981;6:359–368
  16. Olson DM, Skinner K, Challis JR. Prostaglandin output in relation to parturition by cells dispersed from human intrauterine tissues. J Clin Endocrinol Metab. 1983;57:694–699
  17. Kredentser JV, Embree JE, McCoshen JA. Prostaglandin F2 alpha output by amnion–chorion–decidua: relationship with labor and prostaglandin E2 concentration at the amniotic surface. Am J Obstet Gynecol. 1995;173:199–204
  18. Hirst JJ, Mijovic JE, Zakar T, Olson DM. Prostaglandin endoperoxide H synthase-1 and -2 mRNA levels and enzyme activity in human decidua at term labor. J Soc Gynecol Investig. 1998;5:13–20
  19. Watanabe K, Yoshida R, Shimizu T, Hayaishi O. Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. J Biol Chem. 1985;260:7035–7041
  20. Van Meir CA, Sangha RK, Walton JC, Matthews SG, Keirse MJ, Challis JR. Immunoreactive 15-hydroxyprostaglandin dehydrogenase (PGDH) is reduced in fetal membranes from patients at preterm delivery in the presence of infection. Placenta. 1996;17:291–297
  21. Sangha RK, Walton JC, Ensor CM, Tai HH, Challis JR. Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor. J Clin Endocrinol Metab. 1994;78:982–989
  22. Mitchell BF, Rogers K, Wong S. The dynamics of prostaglandin metabolism in human fetal membranes and decidua around the time of parturition. J Clin Endocrinol Metab. 1993;77(3):759–764
  23. Matsumoto T, Sagawa N, Yoshida M, Mori T, Tanaka I, Mukoyama M, et al. The prostaglandin E2 and F2 alpha receptor genes are expressed in human myometrium and are down-regulated during pregnancy. Biochem Biophys Res Commun. 1997;238:838–841
  24. Brodt-Eppley J, Myatt L. Prostaglandin receptors in lower segment myometrium during gestation and labor. Obstet Gynecol. 1999;93:89–93
  25. Alfaidy N, Xiong ZG, Myatt L, Lye SJ, MacDonald JF, Challis JR. Prostaglandin F2alpha potentiates cortisol production by stimulating 11beta-hydroxysteroid dehydrogenase 1: a novel feedback loop that may contribute to human labor. J Clin Endocrinol Metab. 2001 Nov;86(11):5585–5592
  26. Senior J, Marshall K, Sangha R, Clayton JK. In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Br J Pharmacol. 1993;108:501–506
  27. Fuchs AR, Fuchs F, Husslein P, Soloff MS. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol. 1984;150:734–741
  28. Wathes DC, Borwick SC, Timmons PM, Leung ST, Thornton S. Oxytocin receptor expression in human term and preterm gestational tissues prior to and following the onset of labour. J Endocrinol. 1999;161:143–151
  29. Blanks AM, Vatish M, Allen MJ, Ladds G, de Wit NC, Slater DM, et al. Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor. J Clin Endocrinol Metab. 2003;88:3392–3400
  30. Takahashi K, Diamond F, Bieniarz J, Yen H, Burd L. Uterine contractility and oxytocin sensitivity in preterm, term, and postterm pregnancy. Am J Obstet Gynecol. 1980;136:774–779
  31. Mitchell BF, Schmid B. Oxytocin and its receptor in the process of parturition. J Soc Gynecol Investig. 2001;8:122–133
  32. Baguma-Nibasheka M, Nathanielsz PW. In vivo administration of nimesulide, a selective PGHS-2 inhibitor, increases in vitro myometrial sensitivity to prostaglandins while lowering sensitivity to oxytocin. J Soc Gynecol Investig. 1998;5:296–299
  33. Blanks AM, Thornton S. The role of oxytocin in parturition. Br J Obstet Gynaecol. 2003;110(Suppl. 20):46–51

 Grant Support: Canadian Institutes of Health Research, Juntendo University School of Medicine.

PII: S0143-4004(06)00166-4

doi: 10.1016/j.placenta.2006.06.010

Placenta
Volume 28, Issue 5 , Pages 557-565 , May 2007