Placenta
Volume 28 , Pages S48-S50 , April 2007

Oxidative Stress and Pregnancy Outcome: A Workshop Report

  • N. Sugino

      Affiliations

    • Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1-1-1, Ube 755-8505, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 836 22 2286; fax: +81 836 22 2287.
    • ,
  • S. Takiguchi

      Affiliations

    • Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1-1-1, Ube 755-8505, Japan
    • ,
  • T. Umekawa

      Affiliations

    • Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan
    • ,
  • A. Heazell

      Affiliations

    • Maternal and Fetal Health Centre, St Mary's Hospital, Manchester, UK
    • ,
  • I. Caniggia

      Affiliations

    • Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Canada

,Accepted 24 January 2007.

References 

  1. Myatt L, Cui X. Oxidative stress in the placenta. Histochem Cell Biol. 2004;122:369–382
  2. Burton GJ, Jauniaux E. Placental oxidative stress: from miscarriage to preeclampsia. J Soc Gynecol Investig. 2004;11:342–352
  3. Sugino N, Shimamura K, Takiguchi S, Tamura H, Ono M, Nakata M, et al. Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and in early pregnancy. Hum Reprod. 1996;11:1073–1078
  4. Sugino N, Nakata M, Kashida S, Karube A, Takiguchi S, Kato H. Decreased superoxide dismutase expression and increased concentrations of lipid peroxide and prostaglandin F2α in the decidua of failed pregnancy. Mol Hum Reprod. 2000;6:642–647
  5. Sugino N, Kashida S, Takiguchi S, Nakamura Y, Kato H. Induction of superoxide dismutase by decidualization in human endometrial stromal cells. Mol Hum Reprod. 2000;6:178–184
  6. Sugino N, Karube-Harada A, Kashida S, Takiguchi S, Kato H. Reactive oxygen species stimulate prostaglandin F2α production in human endometrial stromal cells in vitro. Hum Reprod. 2001;16:1797–1801
  7. Sugino N, Karube-Harada A, Kashida S, Takiguchi S, Kato H. Differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase by progesterone withdrawal in human endometrial stromal cells. Mol Hum Reprod. 2002;8:68–74
  8. Sugino N, Karube-Harada A, Sakata A, Takiguchi S, Kato H. Nuclear factor-κB is required for tumor necrosis factor-alpha induced manganese superoxide dismutase expression in human endometrial stromal cells. J Clin Endocrinol Metab. 2002;87:3845–3850
  9. Sugino N, Karube-Harada A, Sakata A, Takiguchi S, Kato H. Different mechanisms for the induction of copper-zinc superoxide dismutase and manganese superoxide dismutase by progesterone in human endometrial stromal cells. Hum Reprod. 2002;17:1709–1714
  10. Sugino N, Karube-Harada A, Taketani T, Sakata A, Nakamura Y. Withdrawal of ovarian steroids stimulates prostaglandin F2α production through nuclear factor-κB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation. J Reprod Dev. 2004;50:215–225
  11. Takagi Y, Nikaido T, Toki T, Kita N, Kanai M, Ashida T, et al. Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. Virchows Arch. 2004;444:49–55
  12. Myatt L. Placental adaptive responses and fetal programming. J Physiol. 2006;572:25–30
  13. Ejima K, Nanri H, Toki N, Kashimura M, Ikeda M. Localization of thioredoxin reductase and thioredoxin in normal human placenta and their protective effect against oxidative stress. Placenta. 1999;20:95–101
  14. Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstet Gynecol. 2000;96:271–276
  15. Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez JB, Samoto T, Maruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intra uterine growth retardation. Am J Obstet Gynecol. 2002;186:158–166
  16. Soleymanlou N, Wu Y, Wang X, Jurisicova A, Post M, Caniggia I. A novel pro-apoptotic aplice isoform of Mtd and its role in the pathogenesis of preeclampsia. Cell Death Differ. 2005;12:441–452
  17. Huppertz B, Kadyrov M, Kingdom JCP. Apoptosis and its role in the trophoblast. Am J Obstet Gynecol. 2006;195:29–39
  18. Jurisicova A, Detmar J, Cannigia I. Molecular mechanisms of trophoblast survival: from implantation to birth. Birth Defects Res C Embryo Today. 2005;75:262–280
  19. Wang Y, Walsh SW. Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia. Placenta. 2001;22:206–212
  20. Hung TH, Skepper JN, Charnock-Jones DS, Burton GJ. Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res. 2002;90:1274–1281
  21. Soleymanlou N, Jurisica I, Nevo O, Ietta F, Zhang X, Zamudio S, et al. Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab. 2005;90:4299–4308

PII: S0143-4004(07)00017-3

doi: 10.1016/j.placenta.2007.01.013

Placenta
Volume 28 , Pages S48-S50 , April 2007

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