Placenta
Volume 28, Issue 11 , Pages 1123-1132 , November 2007

Evidence for a Role of TGF-β1 in the Expression and Regulation of α-SMA in Fetal Growth Restricted Placentae

  • T. Todros

      Affiliations

    • Department of Obstetrics and Gynecology, University of Turin, 10126 Turin, Italy
    • T. Todros and D. Marzioni equally contributed to this work as first authors.
    • ,
  • D. Marzioni

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60020 Ancona, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 071 220 6081/6086; fax: +39 071 220 6087.
    • T. Todros and D. Marzioni equally contributed to this work as first authors.
    • ,
  • T. Lorenzi

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60020 Ancona, Italy
    • ,
  • E. Piccoli

      Affiliations

    • Department of Obstetrics and Gynecology, University of Turin, 10126 Turin, Italy
    • ,
  • L. Capparuccia

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60020 Ancona, Italy
    • ,
  • V. Perugini

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60020 Ancona, Italy
    • ,
  • S. Cardaropoli

      Affiliations

    • Department of Obstetrics and Gynecology, University of Turin, 10126 Turin, Italy
    • ,
  • R. Romagnoli

      Affiliations

    • Department of Physiology, Division of Immunoendocrinology and Reproductive Physiology, University of Siena, 53100 Siena, Italy
    • ,
  • R. Gesuita

      Affiliations

    • Centre of Epidemiology, Bio-statistic and Medical Information, Polytechnic University of Marche, 60020 Ancona, Italy
    • ,
  • A. Rolfo

      Affiliations

    • Department of Obstetrics and Gynecology, University of Turin, 10126 Turin, Italy
    • ,
  • L. Paulesu

      Affiliations

    • Department of Physiology, Division of Immunoendocrinology and Reproductive Physiology, University of Siena, 53100 Siena, Italy
    • ,
  • M. Castellucci

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60020 Ancona, Italy

,Accepted 8 June 2007.

References 

  1. Mühlhauser J, Marzioni D, Morroni M, Vuckovic M, Crescimanno C, Castellucci M. Codistribution of basic fibroblast growth factor and heparan sulfate proteoglycan in the growth zones of the human placenta. Cell Tissue Res. 1996;285:101–107
  2. Benirschke K, Kaufmann P, Baergen RN. Pathology of the human placenta. 5th ed.. New York: Springer; 2006;
  3. Castellucci M, Kosanke G, Verdenelli F, Huppertz B, Kaufmann P. Villous sprouting: fundamental mechanisms of human placental development. Human Reprod Update. 2000;6:485–494
  4. Marzioni D, Capparuccia L, Todros T, Giovannelli A, Castellucci M. Growth factors and their receptors: fundamental molecules for human placental development. Ital J Anat Embryol. 2005;110:183–187
  5. Schilling B, Yeh J. Transforming growth factor-β1, -β2, -β3 and their type I and II receptors in human term placenta. Gynecol Obstet Invest. 2000;50:19–23
  6. Zwaagstra JC, Kassam Z, O'Connor-McCourt MD. Down-regulation of transforming growth factor-β receptors: cooperativity between the types I, II, and III receptors and modulation at the cell surface. Exp Cell Res. 1999;252:352–362
  7. Xie W, Mertens JC, Reiss DJ, Rimm DL, Camp RL, Haffty BG, et al. Alterations of Smad signalling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Cancer Res. 2002;62:497–505
  8. Arora PD, Narani N, McCulloch CAG. The compliance of collagen gels regulates transforming growth factor-β induction of α-smooth muscle actin in fibroblasts. Am J Pathol. 1999;154:871–882
  9. Vaughan MB, Howard EW, Tomasek JJ. Transforming growth factor-β1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res. 2000;257:180–189
  10. Kohnen G, Kertschanska S, Demir R, Kaufmann P. Placental villous stroma as a model system for myofibroblast differentiation. Histochem Cell Biol. 1996;105:415–429
  11. Karsdorp VH, van Vugt JM, van Geijn HP, Kostense PJ, Arduini D, Montenegro N, et al. Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery. Lancet. 1994;344:1664–1668
  12. Jarvis S, Glinianaia SV, Torrioli MG, Platt MJ, Miceli M, Jouk PS, et al. Cerebral palsy and intrauterine growth in single births: European collaborative study. Lancet. 2003;362:1106–1111
  13. GRIT study group. Infant wellbeing in the Growth Restriction Interventional Trial (GRIT): multicentred randomised controlled trial. Lancet. 2004;364:513–520
  14. GRIT Study Group. A randomised trial of timed delivery for the compromised preterm fetus: short term outcomes and Bayesian interpretation. Br J Obstet Gynaecol. 2003;110:27–32
  15. Egbor M, Ansari T, Morris N, Green CJ, Sibbons PD. Pre-eclampsia and fetal growth restriction: how morphometrically different is the placenta?. Placenta. 2006;27:727–734
  16. Egbor M, Ansari T, Morris N, Green CJ, Sibbons PD. Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction. BJOG. 2006;113:580–589
  17. Pardi G, Cetin I. Human fetal growth and organ development: 50 years of discoveries. Am J Obstet Gynecol. 2006;194:1088–1099
  18. Francis ST, Duncan KR, Moore RJ, Baker PN, Johnson IR, Gowland PA. Non-invasive mapping of placental perfusion. Lancet. 1998;351:1397–1399
  19. Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and by small for gestational age infants. Br J Obstet Gynaecol. 1986;10:1049–1059
  20. Hitschold T, Weiss E, Beck T, Hunterfering H, Berle P. Low target birth weight or growth retardation? Umbilical Doppler flow velocity waveforms and histometric analysis of fetoplacental vascular tree. Am J Obstet Gynecol. 1993;168:1260–1264
  21. Hitschold TP. Doppler flow velocity waveforms of the umbilical arteries correlate with intravillous blood volume. Am J Obstet Gynecol. 1998;179:540–543
  22. Todros T, Sciarrone A, Piccoli E, Guiot C, Kaufmann P, Kingdom J. Umbilical Doppler waveforms and placental villous angiogenesis in pregnancies complicated by fetal growth restriction. Obstet Gynecol. 1999;93:499–503
  23. Bower S, Bewley S, Campbell S. Improved prediction of preeclampsia by two-stage screening of uterine arteries using the early diastolic notch and color Doppler imaging. Obstet Gynecol. 1993;82:78–83
  24. Nicolini U, Ferrazzi E, Molla R, Massa E, Cicognani G, Santarone M, et al. Accuracy of an average ultrasonic laboratory in measurements of fetal biparietal diameter, head circumference and abdominal circumference. J Perinat Med. 1986;14:101–107
  25. Todros T, Ronco G, Fianchino O, Rosso S, Gabrielli S, Valsecchi L, et al. Accuracy of the umbilical arteries Doppler flow velocity waveforms in detecting adverse perinatal outcomes in a high-risk population. Acta Obstet Gynecol Scand. 1996;75:113–119
  26. Parazzini F, Cortinovis I, Bortolus R, Fedele L. Standard di peso alla nascita in Italia. Ann Ost Gin Med Perin. 1991;CXII:203–246
  27. Report of National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183:S1–S22
  28. Caniggia I, Taylor CV, Ritchie JW, Lye SJ, Letarte M. Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explants. Endocrinology. 1997;138:4977–4988
  29. Kobayashi K, Kubota T, Aso T. Study on myofibroblast differentiation in the stromal cells of Wharton's jelly: expression and localization of alpha-smooth muscle actin. Early Hum Dev. 1998;51:223–233
  30. Hermes B, Welker P, Feldmann-Boddekeer I, Kruger-Krasagakis S, Hartmann K, Zuberbier T, et al. Expression of mast cell growth modulating and chemotactic factors and their receptors in human cutaneous scars. J Invest Dermatol. 2001;116:387–393
  31. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–685
  32. Capparuccia L, Marzioni D, Giordano A, Fazioli F, De Nictolis M, Busso N, et al. PPARgamma expression in normal human placenta, hydatidiform mole and choriocarcinoma. Mol Hum Reprod. 2002;8:574–579
  33. Todros T, Guiot C, Pianta PG. Modelling the feto-placental circulation: 2. A continuous approach to explain normal and abnormal flow velocity waveforms in the umbilical arteries. Ultrasound Med Biol. 1992;18:545–551
  34. Macara L, Kingdom JC, Kohnen G, Bowman AW, Greer IA, Kaufmann P. Elaboration of stem villous vessels in growth restricted pregnancies with abnormal umbilical artery Doppler waveforms. Br J Obstet Gynaecol. 1995;102:807–812
  35. Hinz B, Mastrangelo D, Iselin CE, Chaponnier C, Gabbiani G. Mechanical tension controls granulation tissue conctractile activity and myofibroblast differentiation. Am J Pathol. 2001;159:1009–1020
  36. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002;3:349–363
  37. Serini G, Gabbiani G. Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res. 1999;250:273–283
  38. Ronnov-Jessen L, Petersen OW. Induction of alpha-muscle actin by transforming growth factor-beta1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab Invest. 1993;68:696–707
  39. Sieczkiewicz GJ, Herman IM. TGF-beta1 signaling controls retinal pericyte contractile protein expression. Microvasc Res. 2003;66:190–196
  40. Cucina A, Sterpetti AV, Borrelli V, Pagliei S, Cavallaro A, D'Angelo LS. Shear stress induces transforming growth factor beta-1 release by arterial endothelial cells. Surgery. 1998;123:212–217
  41. Guiot C, Russo R, Sciarrone A, Biolcati M, Piccoli E, Kaufmann P, et al. Placental stem villi arteries in fetal growth restricted pregnancies are different from normal: a multivariate analysis. Intern J Gynecol Obstet. 2003;55:32–36

PII: S0143-4004(07)00146-4

doi: 10.1016/j.placenta.2007.06.003

Placenta
Volume 28, Issue 11 , Pages 1123-1132 , November 2007

Article Tools

* Image Usage & Resolution