Placenta
Volume 29, Issue 5 , Pages 391-395 , May 2008

Expression of Extracellular Signal-Regulated Kinase1/2 and p38 Mitogen-Activated Protein Kinase in the Invasive Trophoblasts at the Human Placental Bed

  • K.C. Moon

      Affiliations

    • Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • J.S. Park

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-744, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 2 2072 3199; fax: +82 2 762 3599.
    • ,
  • E.R. Norwitz

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    • ,
  • D.I. Kim

      Affiliations

    • Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • K.J. Oh

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • C.-W. Park

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • J.K. Jun

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • H.C. Syn

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-744, Republic of Korea

,Accepted 1 February 2008.

References 

  1. Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 2003;69(1):1–7
  2. Lyall F. Priming and remodelling of human placental bed spiral arteries during pregnancy – a review. Placenta. 2005;26(Suppl. A):S31–S36
  3. Pijnenborg R, Vercruysse L, Hanssens M. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta. 2006;27(9–10):939–958
  4. Naicker T, Khedun SM, Moodley J, Pijnenborg R. Quantitative analysis of trophoblast invasion in preeclampsia. Acta Obstet Gynecol Scand. 2003;82(8):722–729
  5. Kim YM, Chaiworapongsa T, Gomez R, Bujold E, Yoon BH, Rotmensch S, et al. Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes. Am J Obstet Gynecol. 2002;187(5):1137–1142
  6. Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, et al. Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2003;189(4):1063–1069
  7. Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu. 1972;1:177–191
  8. Brosens I, Dixon HG, Robertson WB. Fetal growth retardation and the arteries of the placental bed. Br J Obstet Gynaecol. 1977;84(9):656–663
  9. Pollheimer J, Knofler M. Signalling pathways regulating the invasive differentiation of human trophoblasts: a review. Placenta. 2005;26(Suppl. A):S21–S30
  10. Widmann C, Gibson S, Jarpe MB, Johnson GL. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev. 1999;79(1):143–180
  11. Qi M, Elion EA. MAP kinase pathways. J Cell Sci. 2005;118(Pt 16):3569–3572
  12. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001;22(2):153–183
  13. Qiu Q, Yang M, Tsang BK, Gruslin A. Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration. Mol Hum Reprod. 2004;10(9):677–684
  14. McKinnon T, Chakraborty C, Gleeson LM, Chidiac P, Lala PK. Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK. J Clin Endocrinol Metab. 2001;86(8):3665–3674
  15. Liu J, Chakraborty C, Graham CH, Barbin YP, Dixon SJ, Lala PK. Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, phosphatidylinositol 3-kinase and mitogen-activated protein kinase. Exp Cell Res. 2003;286(1):138–151
  16. Johnstone ED, Sibley CP, Lowen B, Guilbert LJ. Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11/14 (p38 MAP kinase) activation. Biol Reprod. 2005;73(6):1282–1288
  17. Gleeson LM, Chakraborty C, McKinnon T, Lala PK. Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein Kinase pathway. J Clin Endocrinol Metab. 2001;86(6):2484–2493
  18. Daoud G, Amyot M, Rassart E, Masse A, Simoneau L, Lafond J. ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta. J Physiol. 2005;566(Pt 2):409–423
  19. Chakraborty C, Barbin YP, Chakrabarti S, Chidiac P, Dixon SJ, Lala PK. Endothelin-1 promotes migration and induces elevation of [Ca2+]i and phosphorylation of MAP kinase of a human extravillous trophoblast cell line. Mol Cell Endocrinol. 2003;201(1–2):63–73
  20. Cartwright JE, Tse WK, Whitley GS. Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthase. Exp Cell Res. 2002;279(2):219–226
  21. Kita N, Mitsushita J, Ohira S, Takagi Y, Ashida T, Kanai M, et al. Expression and activation of MAP kinases, ERK1/2, in the human villous trophoblasts. Placenta. 2003;24(2–3):164–172
  22. Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol. 2000;183(1):S1–S22
  23. ACOG practice bulletin . Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002 Obstet Gynecol. 2002;99(1):159–167
  24. Robertson WB, Khong TY, Brosens I, De Wolf F, Sheppard BL, Bonnar J. The placental bed biopsy: review from three European centers. Am J Obstet Gynecol. 1986;155(2):401–412
  25. Robson SC, Simpson H, Ball E, Lyall F, Bulmer JN. Punch biopsy of the human placental bed. Am J Obstet Gynecol. 2002;187(5):1349–1355
  26. Salafia CM, Weigl C, Silberman L. The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol. 1989;73(3 Pt 1):383–389
  27. Bass KE, Morrish D, Roth I, Bhardwaj D, Taylor R, Zhou Y, et al. Human cytotrophoblast invasion is up-regulated by epidermal growth factor: evidence that paracrine factors modify this process. Dev Biol. 1994;164(2):550–561
  28. Chakraborty C, Gleeson LM, McKinnon T, Lala PK. Regulation of human trophoblast migration and invasiveness. Can J Physiol Pharmacol. 2002;80(2):116–124
  29. Fitzgerald JS, Tsareva SA, Poehlmann TG, Berod L, Meissner A, Corvinus FM, et al. Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells. Int J Biochem Cell Biol. 2005;37(11):2284–2296
  30. Kauma SW, Bae-Jump V, Walsh SW. Hepatocyte growth factor stimulates trophoblast invasion: a potential mechanism for abnormal placentation in preeclampsia. J Clin Endocrinol Metab. 1999;84(11):4092–4096
  31. Tse WK, Whitley GS, Cartwright JE. Transforming growth factor-beta1 regulates hepatocyte growth factor-induced trophoblast motility and invasion. Placenta. 2002;23(10):699–705
  32. Qiu Q, Yang M, Tsang BK, Gruslin A. EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways. Reproduction. 2004;128(3):355–363
  33. Pijnenborg R, Bland JM, Robertson WB, Dixon G, Brosens I. The pattern of interstitial trophoblastic invasion of the myometrium in early human pregnancy. Placenta. 1981;2(4):303–316
  34. Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, et al. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A. 2000;97(19):10454–10459

☆ This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2005-015-E00143).

PII: S0143-4004(08)00045-3

doi: 10.1016/j.placenta.2008.02.001

Placenta
Volume 29, Issue 5 , Pages 391-395 , May 2008

Article Tools

* Image Usage & Resolution