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Placenta
Volume 29, Issue 6
, Pages 469-483
, June 2008
A Hypothesis for Preeclampsia: Adenosine and Inducible Nitric Oxide Synthase in Human Placental Microvascular Endothelium
References
- . Gestational diabetes and the adenosine/l-arginine/nitric oxide (ALANO) pathway in human umbilical vein endothelium. Placenta. 2006;27:1–10
- . Placental adaptive responses and fetal programming. J Physiol. 2006;572:25–30
- . Equilibrative nucleoside (ENTs) and cationic amino acid (CATs) transporters: implications in foetal endothelial dysfunction in human pregnancy diseases. Curr Vasc Pharmacol. 2007;5:69–84
- . Pre-eclampsia—still a disease of theories. Fukushima J Med Sci. 2003;49:69–115
- . Pre-eclampsia: clinical manifestations and molecular mechanisms. Nephron Clin Pract. 2007;106:c72–c81
- . Relation between adenosine and T-helper 1/T-helper 2 imbalance in women with preeclampsia. Obstet Gynecol. 2002;99:641–646
- . The relationship between uterine artery Doppler velocimetry and umbilical venous adenosine levels in pregnancies complicated by preeclampsia. Am J Obstet Gynecol. 1996;174:267–271
- Role of adenosine transport in gestational diabetes-induced l-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. J Physiol. 2004;560:111–122
- . The equilibrative nucleoside transporter family, SLC29. Pflügers Arch. 2004;447:735–743
- . Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension. 2005;46:1077–1085
- . Disminución del flujo placentario en preeclampsia severa: ¿está involucrada adenosina en éste fenómeno?. Bol Soc Esp Cienc Fisiol. 2007;9:6–9
- . Current topic: pre-eclampsia and the placenta. Placenta. 1991;12:301–308
- . Pathophysiology of preeclampsia: linking placental. Microcirculation. 2002;9:147–160
- . The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy. 2001;20:IX–XIV
- . Maternal mortality in Northern Nigeria: a population-based study. Eur J Obstet Gynecol Reprod Biol. 2003;109:153–159
- World Health Organization Antenatal Care Trial Research Group. Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions?. Am J Obstet Gynecol. 2006;194:921–931
- . Pre-eclampsia. Lancet. 2005;365:785–799
- . Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction. Placenta. 2003;24:219–226
- . Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction. BJOG. 2006;113:580–589
- . The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive conductances. Placenta. 2007;28:233–238
- . Transvaginal Doppler ultrasound of the uteroplacental circulation in the early prediction of pre-eclampsia and intrauterine growth retardation. Br J Obstet Gynaecol. 1997;104:674–681
- . Prostacyclin deficiency and reduced fetoplacental blood flow in pregnancy-induced hypertension and preeclampsia. Gynecol Obstet Invest. 2000;50:103–107
- A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia. J Ultrasound Med. 2002;21:831–836
- . Preeclampsia—abnormal uterine artery Doppler is related to recurrence of symptoms during the next pregnancy. J Perinat Med. 2004;32:400–403
- . Second trimester Doppler ultrasound screening of the uterine arteries differentiates between subsequent normal and poor outcomes of hypertensive pregnancy: two different pathophysiological entities?. Clin Sci (Lond). 2004;106:377–382
- Uterine artery velocity waveforms as predictors of pregnancy outcome in patients with antiphospholipid syndrome: a review. Ann N Y Acad Sci. 2007;1108:530–539
- . Regulation of fetal vascular tone in the human placenta. Reprod Fertil Dev. 1991;3:475–481
- . Contribution of endogenous endothelin-1 to basal vascular tone during normal pregnancy and preeclampsia. Am J Obstet Gynecol. 2005;193:234–240
- Expression and function of potassium channels in the human placental vasculature. Am J Physiol Regul Integr Comp Physiol. 2006;291:R437–R446
- . Relaxation of human placental arteries and veins by ATP-sensitive potassium channel openers. Eur J Clin Invest. 2007;37:65–72
- . Vasorelaxant effect of levcromakalim on isolated umbilical arteries of preeclamptic women. Eur J Obstet Gynecol Reprod Biol. 2007;134:169–173
- . Regulation of human placental fetal vessel tone: role of nitric oxide. Reprod Fertil Dev. 1995;7:1407–1411
- . Adenosine causes a biphasic response in the ovine fetal placental vasculature. J Dev Physiol. 1990;13:237–240
- . A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade. Am J Physiol Heart Circ Physiol. 2005;288:H2439–H2449
- . Alteration of human placental vascular tone by antiarrhythmic medications in vitro. J Cardiovasc Electrophysiol. 1996;7:1197–1203
- Restricted innervation of uterus and placenta during pregnancy: evidence for a role of the repelling signal Semaphorin 3A. Dev Dyn. 2004;231:839–848
- . Pregnancy, vascular tone, and maternal hemodynamics: a crucial adaptation. Obstet Gynecol Surv. 2000;55:574–581
- . Determinants of placental vascularity. Am J Reprod Immunol. 2004;51:257–268
- . Preeclampsia: current understanding of the molecular basis of vascular dysfunction. Expert Rev Mol Med. 2006;8:1–20
- . Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends Mol Med. 2006;12:223–233
- . Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol. 1998;274:L212–L219
- . Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis. Curr Diab Rep. 2005;5:17–23
- . The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol. 2006;147:S193–S201
- Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem. 1998;273:15148–15156
- . Identification of residues critical for enzymatic activity in the domain encoded by exons 8 and 9 of the human inducible nitric oxide synthase. Am J Respir Cell Mol Biol. 2001;24:616–620
- . The l-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002–2012
- . Enzymes of the l-arginine to nitric oxide pathway. J Nutr. 2004;134:2748S–2751S
- . Physiological change in platelet aggregation and nitric oxide levels during menstrual cycle in healthy women. Nitric Oxide. 2002;7:217–220
- . Nitrite as an intrinsic signaling molecule. Nat Chem Biol. 2005;1:245–246
- . Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A. 2006;103:5379–5384
- Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res. 2006;99:715–722
- . Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol. 2005;6:150–166
- . Regulation of mitochondrial respiration by oxygen and nitric oxide. Ann N Y Acad Sci. 2000;899:121–135
- Mitochondrial nitric-oxide synthase: role in pathophysiology. IUBMB Life. 2003;55:599–603
- Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci U S A. 1992;89:7674–7677
- . S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation. Am J Physiol Cell Physiol. 2003;284:C1516–C1524
- . Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells. Am J Physiol Heart Circ Physiol. 2005;289:H852–H861
- . Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues. Free Radic Biol Med. 2004;36:413–422
- . S-nitrosoprotein formation and localization in endothelial cells. Proc Natl Acad Sci U S A. 2005;102:117–122
- . NO in early pregnancy and development of preeclampsia. Hypertension. 2006;47:e17
- . Effects of NO donors and synthase agonists on endothelial cell uptake of l-Arg and superoxide production. Am J Physiol Cell Physiol. 2000;278:C136–C143
- . Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol Pharmacol. 2000;57:68–74
- . Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y+/hCAT-1 and y+/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells. Circ Res. 2002;91:127–134
- . Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev. 2003;83:183–252
- . Dysfunction of the endothelial nitric oxide signalling pathway in diabetes and hyperglycaemia. Exp Physiol. 1997;82:423–452
- Rapid stimulation of l-arginine transport by d-glucose involves p42/44(mapk) and nitric oxide in human umbilical vein endothelium. Circ Res. 2003;92:64–72
- . Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium. Exp Physiol. 2003;88:699–710
- . Assessment of risk for the development of pre-eclampsia by maternal characteristics and uterine artery Doppler. BJOG. 2005;112:703–709
- . Intraplatelet cyclic guanosine-3′,5′-monophosphate levels during pregnancy and preeclampsia. Hypertens Pregnancy. 2004;23:303–308
- Cyclic guanosine 3′,5′ monophosphate concentrations in pre-eclampsia: effects of hydralazine. Br J Obstet Gynaecol. 1996;103:33–38
- Urinary cyclic GMP, endothelin, and prostaglandin E2 in normal pregnancy and preeclampsia. Am J Perinatol. 1997;14:559–562
- . Changes in endothelial function precede the clinical disease in women in whom preeclampsia develops. Hypertension. 2005;46:1123–1128
- . High-altitude hypoxia and preeclampsia. Front Biosci. 2007;12:2967–2977
- . Maternal-fetal metabolism in normal pregnancy and preeclampsia. Front Biosci. 2007;12:2457–2470
- . Nitric oxide concentrations are increased in the fetoplacental circulation in preeclampsia. Am J Obstet Gynecol. 1995;173:714–718
- . The vascular endothelium in normal pregnancy and pre-eclampsia. Rev Reprod. 1996;1:107–116
- . Maternal and fetal nitric oxide production in normal and abnormal pregnancy. J Matern Fetal Neonatal Med. 2003;13:22–27
- . Vasoactive mediator release by fetal endothelial cells in intrauterine growth restriction and preeclampsia. Am J Obstet Gynecol. 2001;184:497–502
- Nitric oxide production by human umbilical vessels in severe pre-eclampsia. J Hypertens. 1994;12:1235–1241
- Nitric oxide synthase activity and Doppler parameters in the fetoplacental and uteroplacental circulation in preeclampsia. Hypertens Pregnancy. 1999;18:115–127
- l-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species. Hypertension. 2004;43:614–622
- . Plasma l-arginine is markedly reduced in pregnant women affected by preeclampsia. J Chromatogr B Biomed Sci Appl. 2001;753:427–431
- Reduced l-arginine level and decreased placental eNOS activity in preeclampsia. Placenta. 2006;27:438–444
- Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events?. Hypertension. 2007;49:90–95
- . Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest. 2005;35:32–37
- . l-arginine supplementation in patients with gestational hypertension: a pilot study. Hypertens Pregnancy. 2007;26:121–130
- . Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002;18:761–766
- . Expression, regulation and function of carrier proteins for cationic amino acids. Curr Opin Nephrol Hypertens. 2002;11:99–107
- . Adenosine reduces l-arginine transport and nitric oxide synthesis in human placental microvascular endothelium in preeclampsia. Acta Biomédica. 2006;77:60;[Abstract]
- . l-Arginine transport across the basal plasma membrane of the syncytiotrophoblast of the human placenta from normal and preeclamptic pregnancies. J Clin Endocrinol Metab. 2003;88:4287–4292
- . Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies. Hum Reprod. 1997;12:167–172
- . Endothelial nitric oxide synthase immunoreactivity in early gestation and in trophoblastic disease. J Clin Pathol. 1998;51:427–431
- Expression of kallikrein, bradykinin b2 receptor, and endothelial nitric oxide synthase in placenta in normal gestation, preeclampsia, and placenta accreta. Endocrine. 2006;29:491–499
- Expression and relationship between endothelin-1 messenger ribonucleic acid (mRNA) and inducible/endothelial nitric oxide synthase mRNA isoforms from normal and preeclamptic placentas. J Clin Endocrinol Metab. 2000;85:2318–2323
- . Placental endothelial nitric oxide synthase localization and expression in normal human pregnancy and pre-eclampsia. Clin Exp Pharmacol Physiol. 2003;30:376–381
- Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies. J Histochem Cytochem. 2005;53:1441–1449
- . Preeclampsia is associated with loss of neuronal nitric oxide synthase expression in vascular smooth muscle cells of the human umbilical cord. Histopathology. 2004;44:116–128
- . Nitric oxide and endothelin in oxygen-dependent regulation of vascular tone of human umbilical vein. Am J Physiol Heart Circ Physiol. 2003;285:H1730–H1737
- Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium. Circ Res. 2005;97:16–24
- . Control of adenosine transport by hypoxia. Circ Res. 2005;97:1–3
- Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism. FASEB J. 2002;16:1584–1594
- . Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells. Pflugers Arch. 2004;448:383–394
- . Calcium channels, potassium channels and membrane potential of smooth muscle cells of human allantochorial placental vessels. Bioelectrochem Bioenerg. 1999;48:407–413
- Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition. Am J Physiol Heart Circ Physiol. 2002;283:H2440–H2249
- . Nitric oxide donors mediate vasodilation in human placental arteries partly through a direct effect on potassium channels. Placenta. 2006;27:181–190
- . Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers. Pharmacol Ther. 2000;85:39–53
- Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A. 1993;90:3491–3495
- Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J Biol Chem. 1994;269:6765–6772
- . Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial and inducible nitric oxide synthases. J Biol Chem. 1996;271:6435–6440
- . Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway. J Biol Chem. 2001;276:24268–24273
- . Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition. Proc Natl Acad Sci U S A. 2003;100:14766–14771
- . Regulation of the expression of inducible nitric oxide synthase. Biol Chem. 2003;384:1343–1364
- . Protein–protein interactions involving inducible nitric oxide synthase. Acta Physiol Scand. 2003;179:137–142
- . Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein–Barr virus reactivation. Cell. 1994;79:1137–1146
- Vascular smooth muscle and nitric oxide synthase. FASEB J. 2002;16:500–508
- Complex contribution of the 3′-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR. J Biol Chem. 2000;275:26040–26049
- . Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. Am J Physiol Renal Physiol. 2003;285:F178–F190
- . Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Am J Physiol Cell Physiol. 2002;282:C395–C402
- . NO suppresses while peroxynitrite sustains NF-kappaB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO. Cardiovasc Res. 2004;63:31–40
- . Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol. 2004;500:255–266
- . Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells. J Immunol. 2005;175:3846–3861
- Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci U S A. 1994;91:10089–10093
- Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radic Biol Med. 2000;29:881–888
- Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. J Biol Chem. 2002;277:35605–35615
- . Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action. Hypertension. 1996;28:488–493
- . Altered mRNA expression of ecNOS and iNOS in myometrium and placenta from women with preeclampsia. Arch Gynecol Obstet. 2001;265:45–50
- . Placental expression of nitric oxide synthase during HELLP syndrome: the correlation with maternal-fetal Doppler velocimetry. Acta Obstet Gynecol Scand. 2005;84:849–853
- Expression of estrogen receptor-alpha, estrogen receptor-beta and placental endothelial and inducible NO synthase in intrauterine growth-restricted and normal placentals. Arch Med Res. 2006;37:967–975
- . Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner. J Biol Chem. 2002;277:3109–3116
- . Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters. Biochem Biophys Res Commun. 1998;248:871–878
- . Regulation of inducible nitric oxide synthase in proinflammatory cytokine-stimulated human primary astrocytes. Free Radic Biol Med. 2005;38:655–664
- Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IkappaB. Exp Mol Med. 2004;36:311–324
- . Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proc Natl Acad Sci U S A. 2001;98:8638–8643
- . Increased circulating lipid peroxides in severe preeclampsia activate NF-kappaB and upregulate ICAM-1 in vascular endothelial cells. FASEB J. 2001;15:279–281
- AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation. 2003;107:1632–1639
- Expression of nuclear factor-kappa B and placental apoptosis in pregnancies complicated with intrauterine growth restriction and preeclampsia: an immunohistochemical study. Tohoku J Exp Med. 2004;204:195–202
- . Pregnancy is associated with suppression of the nuclear factor kappaB/IkappaB activation pathway in peripheral blood mononuclear cells. J Reprod Immunol. 2003;58:27–47
- . Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitamins. Am J Pathol. 2007;170:1511–1520
- . Activation of A2-purinoceptors by adenosine stimulates l-arginine transport (system y+) and nitric oxide synthesis in human fetal endothelial cells. J Physiol. 1997;499:135–140
- . Preeclampsia: recent insights. Hypertension. 2005;46:1243–1249
- . New insights into molecular structure and function of ectonucleotidases in the nervous system. Neurochem Int. 1998;32:421–425
- . International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev. 2001;53:527–552
- . Signalling from adenosine receptors to mitogen-activated protein kinases. Cell Signal. 2003;15:813–827
- . Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Mol Pharmacol. 2005;67:1406–1413
- . Regional and subcellular distribution of S-adenosylhomocysteine hydrolase in the adult rat brain. J Neurochem. 1980;35:484–488
- . The role of receptor structure in determining adenosine receptor activity. Pharmacol Ther. 2000;85:55–75
- . Interactions of purified bovine brain A1-adenosine receptors with G-proteins. Reciprocal modulation of agonist and antagonist binding. Biochem J. 1991;275:651–656
- . A single species of A1 adenosine receptor expressed in Chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release. Mol Pharmacol. 1994;45:1036–1042
- Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor. J Biol Chem. 1994;269:32077–32084
- . Adenosine: old passion, new perspectives. Ital J Biochem. 2004;53:141–147
- . Use of the A(2A) adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo. Biochem Pharmacol. 2003;65:493–501
- Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulation. Circ Res. 2002;90:531–538
- Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotype. Hypertension. 2004;44:649–654
- . Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Invest Ophthalmol Vis Sci. 2001;42:2068–2073
- . Adenosine prevents permeability increase in oxidant-injured endothelial monolayers. Am J Physiol. 1998;274:H35–H42
- . Plasma adenosine levels and P-selectin expression on platelets in preeclampsia. Obstet Gynecol. 2001;97:366–370
- . Increased plasma adenosine concentrations and the severity of preeclampsia. Obstet Gynecol. 2002;100:1266–1270
- . Relation between serum uric acid and plasma adenosine levels in women with preeclampsia. Gynecol Obstet Invest. 2001;51:169–172
- . Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia. Gynecol Obstet Invest. 2001;51:36–39
- . Maternal and fetal plasma adenosine deaminase, xanthine oxidase and malondialdehyde levels in pre-eclampsia. Cell Biochem Funct. 2005;23:279–283
- . Simultaneous measurement of adenosine and hypoxanthine in human umbilical cord plasma using reversed-phase high-performance liquid chromatography with photodiode-array detection and on-line validation of peak purity. J Chromatogr B Biomed Sci Appl. 1998;707:33–41
- . Clinical correlation between adenosine deaminase activity and pre-eclampsia severity. J Int Med Res. 2006;34:247–255
- Cell entry and export of nucleoside analogues. Virus Res. 2005;107:151–164
- Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia. Placenta. 2005;26:641–653
- Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol. 2006;208:451–460
- Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium. J Cell Physiol. 2006;209:826–835
- . Nitric oxide, cGMP and cAMP modulate nitrobenzylthioinosine-sensitive adenosine transport in human umbilical artery smooth muscle cells from subjects with gestational diabetes. Exp Physiol. 2000;85:399–409
- Modulation of adenosine transport by insulin in human umbilical artery smooth muscle cells from normal or gestational diabetic pregnancies. J Physiol. 2001;534:243–254
- . Adenosine transport and nitrobenzylthioinosine binding in human placental membrane vesicles from brush-border and basal sides of the trophoblast. J Membr Biol. 1991;119:151–161
- . Immunolocalisation of nucleoside transporters in human placental trophoblast and endothelial cells: evidence for multiple transporter isoforms. Pflugers Arch. 1995;429:349–394
- . Preeclampsia is associated with increased adenosine transport via the human equilibrative nucleoside transporter 2 in placental microvascular endothelial cells. Placenta. 2007;28:A64;[Abstract]
- . Expression and activity of hNET1 and hENT2 are regulated by adenosine receptor in placenta microvascular endothelium from preeclampsia. Pediatr Res. 2007;62:385;[Abstract]
- . Transporters for cationic amino acids in animal cells: discovery, structure, and function. Physiol Rev. 1998;78:487–545
- . Use of multiple radioligands to characterize adenosine receptors in human placenta. Placenta. 1986;7:339–348
- . Action of adenosine and characterization of adenosine receptors in human placental vasculature. Gen Pharmacol. 1990;21:227–233
- . Vascular actions of purines in the foetal circulation of the human placenta. Br J Pharmacol. 1993;110:454–460
- Production and characterization of multiple antigenic peptide antibodies to the adenosine A2b receptor. Mol Pharmacol. 1995;47:1126–1132
- . Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells. FEBS Lett. 1998;429:139–142
- . Specific inhibition of nuclear factor-kappaB-dependent inflammatory responses by cell type-specific mechanisms upon A2A adenosine receptor gene transfer. Mol Pharmacol. 2004;66:1147–1159
- . Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells. Neuropharmacology. 2005;48:151–160
- . A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency. Blood. 2000;95:3859–3867
- . Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature. 2001;414:916–920
- . Cutting edge: physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo. J Immunol. 2004;173:21–24
- . Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells. Am J Physiol. 1996;270:C522–C529
- . Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway. J Biol Chem. 2005;280:31898–31905
- . Adenosine receptor A2A stimulation decreases nitric oxide synthesis in placental microvascular endotelial cells from women with preeclampsia and intrauterine growth restriction. Early Hum Dev. 2006;82:496;[Abstract]
- . Angiogenesis in the placenta. Biol Reprod. 2001;64:1033–1040
- . Vasculogenesis and angiogenesis in the early human placenta. Acta Histochem. 2007;109:257–265
- . Differentiation of blood–brain barrier endothelial cells. Pathol Biol (Paris). 1998;46:171–175
- . Angiogenesis, vasculogenesis, and induction of healing in chronic wounds. Vasc Endovasc Surg. 2005;39:293–306
- . Adenosine receptors and angiogenesis. Circ Res. 2007;101:1075–1077
- . Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14:1315–1323
- A1 adenosine receptor activation promotes angiogenesis and release of VEGF from monocytes. Circ Res. 2007;101:1130–1138
- . Plgf−/−eNos−/− mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia. FASEB J. 2006;20:970–972
- Elevated vasoinhibins may contribute to endothelial cell dysfunction and low birth weight in preeclampsia. Lab Invest. 2007;87:1009–1017
- . Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. Am J Pathol. 2001;159:993–1008
- . Induction of VE-cadherin in rat placental trophoblasts by VEGF through a NO-dependent pathway. Placenta. 2005;26:234–241
- . Preeclampsia is associated with altered Ca2+ regulation and NO production in human fetal venous endothelial cells. FASEB J. 2002;16:721–723
- Plasma factors in severe early-onset preeclampsia do not substantially alter endothelial gene expression in vitro. J Soc Gynecol Investig. 2005;12:98–106
- . Maternal plasma from pregnant women with umbilical placental vascular disease does not affect endothelial cell mRNA expression of nitric oxide synthase. J Soc Gynecol Investig. 2004;11:149–153
PII: S0143-4004(08)00074-X
doi: 10.1016/j.placenta.2008.02.008
© 2008 Elsevier Ltd. All rights reserved.
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Placenta
Volume 29, Issue 6
, Pages 469-483
, June 2008
