Placenta
Volume 29, Issue 6 , Pages 519-522 , June 2008

Antioxidant Gene Expression in Preeclamptic Placentae: A Preliminary Investigation

  • J. Vanderlelie

      Affiliations

    • School of Medical Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD 9726, Australia
    • ,
  • N. Gude

      Affiliations

    • Department of Perinatal Medicine, Royal Women's Hospital, Melbourne, Australia
    • ,
  • A.V. Perkins

      Affiliations

    • School of Medical Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD 9726, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 7 55528818; fax: +61 7 55528908.

,Accepted 28 February 2008.

References 

  1. Burton GJ, Jauniaux E. Placental oxidative stress: from miscarriage to preeclampsia. Journal of the Society for Gynecologic Investigation. 2004;11(6):342–352
  2. Polyzos NP, Mauri D, Tsappi M, Tzioras S, Kamposioras K, Cortinovis I, et al. Combined vitamin C and E supplementation during pregnancy for preeclampsia prevention: a systematic review. Obstetrical & Gynecological Survey. 2007;62(3):202–206
  3. Vanderlelie J, Venardos K, Clifton VL, Gude NM, Clarke FM, Perkins AV. Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae. Placenta. 2005;26:53–58
  4. Wang Y, Walsh SW, Kay HH. Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia. American Journal of Obstetrics and Gynecology. 1992;167:946–949
  5. Poranen A, Ekblad U, Uotila P, Ahotupa M. Lipid peroxidation and antioxidants in normal and pre-eclamptic pregnancies. Placenta. 1996;17:401–405
  6. Zusterzeel PLM, Rutten H, Roelofs HMJ, Peters WHM, Steegers EAP. Protein carbonyls in decidua and placenta of pre-eclamptic women as markers for oxidative stress. Placenta. 2001;22:213–219
  7. Madazli R, Benian A, Aydin S, Uzun H, Tolun N. The plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in pre-eclampsia. Journal of Obstetrics and Gynecology. 2002;22:477–480
  8. Takehara Y, Yoshioka T, Sasaki J. Changes in the levels of lipoperoxide and antioxidant factors in human placenta during gestation. Acta Medica Okayama. 1990;44:103–111
  9. Wang YP, Walsh SW, Guo JD, Zhang JY. The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood. American Journal of Obstetrics and Gynecology. 1991;165:1695–1700
  10. Wisdom S, Wilson R, McKillop J, Walker J. Antioxidant systems in normal pregnancy and in pregnancy-induced hypertension. American Journal of Obstetrics and Gynecology. 1991;165:1701–1703
  11. Davidge ST, Hubel CA, Brayden RD, Capeless EC, McLaughlin MK. Sera antioxidant activity in uncomplicated and preeclamptic pregnancies. Obstetrics and Gynecology. 1992;79:897–901
  12. Shibata E, Nanri H, Ejima K, Araki M, Fukuda J, Yoshimura K, et al. Enhancement of mitochondrial oxidative stress and up-regulation of antioxidant protein peroxiredoxin III/SP-22 in the mitochondria of human pre-eclamptic placentae. Placenta. 2003;24:698–705
  13. Berggren MI, Husbeck B, Samulitis B, Baker AF, Gallegos A, Powis G. Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin. Archives of Biochemistry and Biophysics. 2001;392:103–109
  14. Raijmakers MT, Zusterzeel PL, Roes EM, Steegers EA, Mulder TP, Peters WH. Oxidized and free whole blood thiols in preeclampsia. Obstet Gynecol. 2001;97(2):272–276
  15. Wang Y, Walsh SW. Antioxidant activities and mRNA expression of superoxide dismutase, catalase, and glutathione peroxidase in normal and preeclamptic placentas. Journal for the Society of Gynecologic Investigation. 1996;3:179–184
  16. Hempstock J, Bao Y-P, Bar-Issac M, Segaren N, Watson AL, Charnock-Jones DS, et al. Intralobular differences in antioxidant enzyme expression and activity reflect the pattern of maternal arterial bloodflow within the human placenta. Placenta. 2003;24:517–523
  17. Sahlin L, Ostlund E, Wang H, Holmgren A, Fried G. Decreased expression of thioredoxin and glutaredoxin in placentae from pregnancies with pre-eclampsia and intrauterine growth restriction. Placenta. 2000;21:603–609
  18. Shibata E, Ejima K, Nanri H. Enhanced protein levels of protein thiol/disulphide oxidoreductases in placentae from pre-eclamptic subjects. Placenta. 2001;22:566–572
  19. Smarason AK, Sargent IL, Starkey PM, Redman CW. The effect of placental syncytiotrophoblast microvillous membranes from normal and pre-eclamptic women on the growth of endothelial cells in vitro. British Journal of Obstetrics and Gynaecology. 1993;100:943–949
  20. Knight M, Redman CW, Linton EA, Sargent IL. Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies. British Journal of Obstetrics and Gynaecology. 1998;105:632–640
  21. Esteve JM, Mompo J, Garcia de la Asuncion J. Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitro. The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology. 1999;13:1055–1064
  22. Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez JB, Samoto T, Mauro T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. American Journal of Obstetrics and Gynecology. 2002;186:158–166
  23. Allaire AD, Ballenger KA, Wells SR, Mcmahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstetrics and Gynecology. 2000;96:271–276
  24. Leung DN, Smith SC, To KF, Sahota DS, Baker PN. Increased placental apoptosis in pregnancies complicated by preeclampsia. American Journal of Obstetrics and Gynecology. 2001;184:1249–1250
  25. Redman CWG, Sargent IL. The pathogenesis of pre-eclampsia. Gynecologie Obstetrique & Fertilite. 2001;29:518–522

PII: S0143-4004(08)00090-8

doi: 10.1016/j.placenta.2008.02.016

Placenta
Volume 29, Issue 6 , Pages 519-522 , June 2008

Article Tools