Placenta
Volume 29, Issue 6 , Pages 549-554 , June 2008

Oct4 is Epigenetically Regulated by Methylation in Normal Placenta and Gestational Trophoblastic Disease

  • H.-J. Zhang

      Affiliations

    • Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    • Department of Pathology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • M.K.-Y. Siu

      Affiliations

    • Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    • ,
  • E.S.-Y. Wong

      Affiliations

    • Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    • ,
  • K.-Y. Wong

      Affiliations

    • Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    • ,
  • A.S.-M. Li

      Affiliations

    • Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    • ,
  • K.Y.-K. Chan

      Affiliations

    • Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    • ,
  • H.Y.-S. Ngan

      Affiliations

    • Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    • ,
  • A.N.-Y. Cheung

      Affiliations

    • Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
    • Corresponding Author InformationCorresponding author. Tel.: +852 28554876; fax: +852 28725197.

,Accepted 14 March 2008.

References 

  1. Paradinas FJ, Elston CW. Gestational trophoblastic diseases. In:  Fox H,  Wells M editor. Haines & Taylor obstetrical and gynaecological pathology. Edinburgh: Churchill Livingstone; 2003;p. 1359–1430
  2. Shih IM, Mazur MT, Kurma RJ. Gestational trophoblastic disease and related lesion. In:  Kurman RJ editors. Blaustein's pathology of the female genital tract. New York: Springer Verlag; 2002;p. 1193–1247
  3. Roberts RM, Ezashi T, Das P. Trophoblast gene expression: transcription factors in the specification of early trophoblast. Reprod Biol Endocrinol. 2004;2:47–55
  4. Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, et al. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 2005;132:2093–2102
  5. Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chamber I, et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998;95:379–391
  6. Pesce M, Schöler HR. Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells. 2001;19:271–278
  7. Takeda J, Seino S, Bell GT. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Nucleic Acids Res. 1992;20:4613–4620
  8. Babaie Y, Herwig R, Greber B, Brink TC, Wruck W, Groth D, et al. Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells. 2007;25:500–510
  9. Schöler HR. Octamania: the POU factors in murine development. Trends Genet. 1991;7:323–329
  10. Hansis C, Grifo JA, Krey LC. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. Mol Hum Reprod. 2000;6:999–1004
  11. Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, et al. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell. 2005;123:917–929
  12. Smithf A. The battlefield of pluripotency. Cell. 2005;123:757–760
  13. Deb-Rinker P, Ly D, Jezierski A, Marianna S, Walker PR. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. J Biol Chem. 2005;280:6257–6260
  14. Hattori N, Nishino K, Ko YG, Hattori N, Ohgane J, Tanaka S, et al. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J Biol Chem. 2004;279:17063–17069
  15. Lai CYL, Chan KYK, Khoo US, Ngan HYS, Xue WC, Chiu PM, et al. Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization. Mod Pathol. 2004;17:40–48
  16. Ngan HYS. The practicability of FIGO 2000 staging for gestational trophoblastic neoplasia. Int J Gynecol Cancer. 2004;14:202–205
  17. Xue WC, Chan KYK, Feng HC, Chiu PM, Ngan HYS, Tsao SW, et al. Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma. J Mol Diagn. 2004;6:326–334
  18. Liao XY, Siu MK, Chan KY, Wong ES, Ngan HY, Chan QK, et al. Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. Int J Cancer, in press.
  19. Nordhoff V, Hübner K, Bauer A, Orlova I, Malapetsa A, Schöler HR. Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences. Mamm Genome. 2001;12:309–317
  20. Shen DH, Chan KYK, Khoo US, Ngan HYS, Xue WC, Chiu PM, et al. Epigenetic and genetic alterations of p33ING1b in ovarian cancer. Carcinogenesis. 2005;26:855–863
  21. Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics. 2002;18:1427–1431
  22. Feng HC, Tsao SW, Ngan HY, Kwan HS, Shih SM, Xue WC, et al. Differential gene expression identified in complete hydatidiform mole by combining suppression subtractive hybridization and cDNA microarray. Placenta. 2006;27:521–526
  23. Feng H, Cheung AN, Xue WC, Wang Y, Wang X, Fu S, et al. Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma. Gynecol Oncol. 2004;94:375–382
  24. Yoshida M, Kijima M, Akita M, Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem. 1990;265:17174–17179
  25. Tarkowski AK, Wroblewska J. Development of blastomeres of mouse eggs isolated at the 4- and 8-cell stage. J Embryol Exp Morphol. 1967;18:1551–1580
  26. Dietrich JE, Hiiragi T. Stochastic patterning in the mouse pre-implantation embryo. Development. 2007;134:4219–4231
  27. Chambers I, Smith A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene. 2004;23:7150–7160
  28. Kunath T. Stem cells: pluripotency and extraembryonic differentiation in the mouse. In:  Moffett A,  Loke C,  McLaren A editor. Biology and pathology of trophoblast. Cambridge University Press; 2006;p. 15–32
  29. Schöler HR, Balling R, Hatzopoulos AK, Suzuki N, Gruss P. Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J. 1989;8:2551–2557
  30. Schöler HR, Hatzopoulos AK, Balling R, Suzuki N, Gruss P. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J. 1989;8:2543–2550
  31. Ohbo K, Yoshida S, Ohmura M, Ohneda O, Ogawa T, Tsuchiya H, et al. Identification and characterization of stem cells in prepubertal spermatogenesis in mice. Dev Biol. 2003;258:209–225
  32. Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet. 2000;24:372–376
  33. Minucci S, Botquin V, Yeom YI, Dey A, Sylvester I, Zand DJ, et al. Retinoic acid-mediated down-regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo. EMBO J. 1996;15:888–899
  34. Arima T, Hata K, Tanaka S, Kusumi M, Li E, Kato K, et al. Loss of the maternal imprint in Dnmt3Lmat−/− mice leads to a differentiation defect in the extraembryonic tissue. Dev Biol. 2006;297:361–373
  35. Tolkunova E, Cavaleri F, Eckardt S, Reinbold R, Christenson LK, Schöler HR, et al. The caudal-related protein cdx2 promotes trophoblast differentiation of mouse embryonic stem cells. Stem Cells. 2006;24:139–144
  36. Liu L, Roberts RM. Silencing of the gene for the beta subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3/4. J Biol Chem. 1996;271:16683–16689
  37. Liu L, Leaman D, Villalta M, Roberts RM. Silencing of the gene for the alpha-subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3/4. Mol Endocrinol. 1997;11:1651–1658
  38. Kohorn E. Regional centers for trophoblastic disease. Am J Obstet Gynecol. 2007;196:95–96
  39. Fulop V, Mok SC, Gati I, Berkowitz RS. Recent advances in molecular biology of gestational trophoblastic diseases. A review. J Reprod Med. 2002;47:369–379
  40. Fisher RA, Hodges MD. Genomic imprinting in gestational trophoblastic disease–a review. Placenta. 2003;24(Suppl. A):S111–S118
  41. Lau SK, Chang KL. OCT4: a sensitive and specific immunohistochemical marker for metastatic germ cell tumors. Adv Anat Pathol. 2006;13:76–79
  42. Rahnama F, Shafiei F, Gluchman PD, Mitchell MD, Lobie PE. Epigenetic regulation of human trophoblastic cell migration and invasion. Endocrinology. 2006;147:5275–5283
  43. Freberg CT, Dahl JA, Timoskainen S, Collas P. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Mol Biol Cell. 2007;18:1543–1553
  44. Vallender TW, Lahn BT. Localized methylation in the key regulator gene endothelin-1 is associated with cell type-specific transcriptional silencing. FEBS Lett. 2006;580:4560–4566

PII: S0143-4004(08)00103-3

doi: 10.1016/j.placenta.2008.03.003

Placenta
Volume 29, Issue 6 , Pages 549-554 , June 2008

Article Tools

* Image Usage & Resolution