Inflammatory Reaction and Implantation: the New Entries PTX3 and D6

PTX3 expression in human placenta and decidua. Immunohistochemistry on third trimester human placenta shows PTX3 expression in ghost villi (*) and interstium (**) of basal plate (A), in the stroma of stem villi (B), in terminal villi (C), and in the fetal membranes (D). Extracellular distribution of PTX3 in first trimester decidua; endometrial glands (**) are negative. (F) Consecutive sections of first trimester decidua stained with anti-PTX3 and anti-cytokeratin 7 (inset) antibodies: PTX3 expression in decidual stroma among trophoblasts (cytokeratin 7-positive cells, brown stained in the inset). Haematoxylin counterstaining, DAB (O.M. 10× in panels A and D; 20× in panel B, E and F; 40× in panel C).

D6 expression in placenta. Immunohistochemistry on first trimester human placenta shows strong and diffuse D6 positivity on the apical side of syncytiotrophoblast cells (A) and on endothelium in decidua (B, arrows). Endometrial glands (B, **) are negative. Haematoxylin counterstaining, DAB (O.M. 10× in panel A, 40× in panel B).