Placenta
Volume 29, Issue 9 , Pages 809-815 , September 2008

The Distribution of Angiopoietin-1, Angiopoietin-2 and Their Receptors Tie-1 and Tie-2 in the Very Early Human Placenta

  • Y. Seval

      Affiliations

    • Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
  • ,
  • L. Sati

      Affiliations

    • Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
  • ,
  • C. Celik-Ozenci

      Affiliations

    • Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
  • ,
  • O. Taskin

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
  • ,
  • R. Demir

      Affiliations

    • Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
    • Corresponding Author InformationCorresponding author. Tel./fax: +90 242 2274486.

,Accepted 20 June 2008.

References 

  1. Kaufmann P, Mayhew TM, Charnock-Jones DS. Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy. Placenta. 2004;25:114–126
  2. Zygmunt M, Herr F, Munstedt K, Lang U, Liang OD. Angiogenesis and vasculogenesis in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2003;110(Suppl 1):S10–S18
  3. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4–25
  4. Hanahan D. Signaling vascular morphogenesis and maintenance. Science. 1997;277:48–50
  5. Iruela-Arispe ML, Dvorak HF. Angiogenesis: a dynamic balance of stimulators and inhibitors. Thromb Haemost. 1997;78:672–677
  6. Shams M, Ahmed A. Localization of mRNA for basic fibroblast growth factor in human placenta. Growth Factors. 1994;11:105–111
  7. Kilby MD, Afford S, Li XF, Strain AJ, Ahmed A, Whittle MJ. Localisation of hepatocyte growth factor and its receptor (c-met) protein and mRNA in human term placenta. Growth Factors. 1996;13:133–139
  8. Shore VH, Wang TH, Wang CL, Torry RJ, Caudle MR, Torry DS. Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast. Placenta. 1997;18:657–665
  9. Vuorela P, Hatva E, Lymboussaki A, Kaipainen A, Joukov V, Persico MG, et al. Expression of vascular endothelial growth factor and placenta growth factor in human placenta. Biol Reprod. 1997;56:489–494
  10. Folkman J, Klagsbrun M. Angiogenic factors. Science. 1987;235:442–447
  11. Dantzer V, Leach L, Leiser R. Angiogenesis and placental vasculature – a workshop report. Placenta. 2000;21(Suppl A):S69–S70
  12. Thomas KA. Vascular endothelial growth factor, a potent and selective angiogenic agent. J Biol Chem. 1996;271:603–606
  13. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25:581–611
  14. Albrecht ED, Babischkin JS, Pepe GJ. Regulation of placental villous angiopoietin-1 and -2 expression by estrogen during baboon pregnancy. Mol Reprod Dev. 2008;75:504–511
  15. Partanen J, Dumont D. Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development. Berlin: Springer-Verlag; 1999;
  16. Yuan HT, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme VP, et al. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. Faseb J. 2007;21:3171–3183
  17. Currie MJ, Gunningham SP, Han C, Scott PA, Robinson BA, Harris AL, et al. Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. Clin Cancer Res. 2001;7:918–927
  18. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science. 1997;277:55–60
  19. Lobov IB, Brooks PC, Lang RA. Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci U S A. 2002;99:11205–11210
  20. Visconti RP, Richardson CD, Sato TN. Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci U S A. 2002;99:8219–8224
  21. Eklund L, Olsen BR. Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp Cell Res. 2006;312:630–641
  22. Wulff C, Wilson H, Dickson SE, Wiegand SJ, Fraser HM. Hemochorial placentation in the primate: expression of vascular endothelial growth factor, angiopoietins, and their receptors throughout pregnancy. Biol Reprod. 2002;66:802–812
  23. Sharkey AM, Charnock-Jones DS, Boocock CA, Brown KD, Smith SK. Expression of mRNA for vascular endothelial growth factor in human placenta. J Reprod Fertil. 1993;99:609–615
  24. Clark DE, Smith SK, Sharkey AM, Charnock-Jones DS. Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy. Hum Reprod. 1996;11:1090–1098
  25. Demir R, Kayisli UA, Seval Y, Celik-Ozenci C, Korgun ET, Demir-Weusten AY, et al. Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis. Placenta. 2004;25:560–572
  26. Demir R, Kayisli UA, Cayli S, Huppertz B. Sequential steps during vasculogenesis and angiogenesis in the very early human placenta. Placenta. 2006;27:535–539
  27. Demir R, Seval Y, Huppertz B. Vasculogenesis and angiogenesis in the early human placenta. Acta Histochem. 2007;109:257–265
  28. Barleon B, Hauser S, Schollmann C, Weindel K, Marme D, Yayon A, et al. Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells. J Cell Biochem. 1994;54:56–66
  29. Achen MG, Gad JM, Stacker SA, Wilks AF. Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development. Growth Factors. 1997;15:69–80
  30. Cheung CY. Vascular endothelial growth factor: possible role in fetal development and placental function. J Soc Gynecol Investig. 1997;4:169–177
  31. Robb VA, Pepe GJ, Albrecht ED. Placental villous vascular endothelial growth factor expression and vascularization after estrogen suppression during the last two-thirds of baboon pregnancy. Endocrine. 2007;31:260–267
  32. Benirschke K, Kaufmann P. Pathology of the human placenta. New York: Springer; 2000;
  33. Asahara T, Chen D, Takahashi T, Fujikawa K, Kearney M, Magner M, et al. Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res. 1998;83:233–240
  34. Hagen AS, Orbus RJ, Wilkening RB, Regnault TR, Anthony RV. Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental insufficiency-fetal growth restriction. Pediatr Res. 2005;58:1228–1232
  35. Dunk C, Shams M, Nijjar S, Rhaman M, Qiu Y, Bussolati B, et al. Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development. Am J Pathol. 2000;156:2185–2199
  36. Babischkin JS, Suresch DL, Pepe GJ, Albrecht ED. Differential expression of placental villous angiopoietin-1 and -2 during early, mid and late baboon pregnancy. Placenta. 2007;28:212–218
  37. Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB. Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. J Clin Endocrinol Metab. 2002;87:4213–4224
  38. Seval Y, Korgun ET, Demir R. Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis. Placenta. 2007;28:841–845
  39. Huang XL, Takakura N, Suda T. In vitro effects of angiopoietins and VEGF on hematopoietic and endothelial cells. Biochem Biophys Res Commun. 1999;264:133–138

PII: S0143-4004(08)00200-2

doi: 10.1016/j.placenta.2008.06.009

Placenta
Volume 29, Issue 9 , Pages 809-815 , September 2008