Placenta
Volume 29, Issue 10 , Pages 879-882 , October 2008

Placental System A Amino Acid Transport is Reduced in Pregnancies With Small For Gestational Age (SGA) Infants but Not in Preeclampsia with SGA Infants

  • E. Shibata

      Affiliations

    • Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • ,
  • C.A. Hubel

      Affiliations

    • Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Corresponding Author InformationCorresponding author. Magee-Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA 15213, USA. Tel.: +1 412 641 6130; fax: +1 412 641 1503.
    • ,
  • R.W. Powers

      Affiliations

    • Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • ,
  • F. von Versen-Hoeynck

      Affiliations

    • Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • ,
  • H. Gammill

      Affiliations

    • Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • ,
  • A. Rajakumar

      Affiliations

    • Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • ,
  • J.M. Roberts

      Affiliations

    • Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA

,Accepted 3 July 2008.

References 

  1. Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol. 1986;93:1049–1059
  2. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamins in Pre-eclampsia Trial C. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. [see comment] Lancet. 2006;367:1145–1154
  3. Mayhew TM, Ohadike C, Baker PN, Crocker IP, Mitchell C, Ong SS. Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction. Placenta. 2003;24:219–226
  4. Mayhew TM, Manwani R, Ohadike C, Wijesekara J, Baker PN. The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive conductances. Placenta. 2007;28:233–238
  5. Mayhew TM, Wijesekara J, Baker PN, Ong SS. Morphometric evidence that villous development and fetoplacental angiogenesis are compromised by intrauterine growth restriction but not by pre-eclampsia. Placenta. 2004;25:829–833
  6. Egbor M, Ansari T, Morris N, Green CJ, Sibbons PD. Pre-eclampsia and fetal growth restriction: how morphometrically different is the placenta?. Placenta. 2006;27:727–734
  7. Egbor M, Ansari T, Morris N, Green CJ, Sibbons PD. Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction. BJOG: Int J Obstet Gynaecol. 2006;113:580–589
  8. Cetin I, Ronzoni S, Marconi AM, Perugino G, Corbetta C, Battaglia FC, et al. Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies. Am J Obstet Gynecol. 1996;174:1575–1583
  9. Cetin I, Marconi AM, Corbetta C, Lanfranchi A, Baggiani AM, Battaglia FC, et al. Fetal amino acids in normal pregnancies and in pregnancies complicated by intrauterine growth retardation. Early Hum Dev. 1992;29:183–186
  10. Pardi G, Marconi AM, Cetin I. Placental-fetal interrelationship in IUGR fetuses—a review. Placenta. 2002;23:S136–S141
  11. Evans RW, Powers RW, Ness RB, Cropcho LJ, Daftary AR, Harger GF, et al. Maternal and fetal amino acid concentrations and fetal outcomes during pre-eclampsia. Reproduction. 2003;125:785–790
  12. Cramer S, Beveridge M, Kilberg M, Novak D. Physiological importance of system A-mediated amino acid transport to rat fetal development. Am J Physiol Cell Physiol. 2002;282:C153–C160
  13. Jansson T, Ylven K, Wennergren M, Powell TL. Glucose transport and system A activity in syncytiotrophoblast microvillous and basal plasma membranes in intrauterine growth restriction. Placenta. 2002;23:392–399
  14. Sibley CP, Turner MA, Cetin I, Ayuk P, Boyd CA, D'Souza SW, et al. Placental phenotypes of intrauterine growth. Pediatr Res. 2005;58:827–832
  15. Gifford RW, August PA, Cunningham G, Green LA, Lindheimer MD, McNellis D, et al. Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy. Am J Obstet Gynecol. 2000;183:S1–S22
  16. Jansson N, Greenwood SL, Johansson BR, Powell TL, Jansson T. Leptin stimulates the activity of the system A amino acid transporter in human placental villous fragments. J Clin Endocrinol Metab. 2003;88:1205–1211
  17. Jansson N, Pettersson J, Haafiz A, Ericsson A, Palmberg I, Tranberg M, et al. Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. [see comment] J Physiol. 2006;576:935–946
  18. Hubel CA. Dyslipidemia, iron, and oxidative stress in preeclampsia: assessment of maternal and feto–placental interactions. Semin Reprod Endocrinol. 1998;16:75–92
  19. Rodie VA, Caslake MJ, Stewart F, Sattar N, Ramsay JE, Greer IA, et al. Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Atherosclerosis. 2004;176:181–187
  20. Rodie VA, Freeman DJ, Sattar N, Greer IA. Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy?. Atherosclerosis. 2004;175:189–202
  21. Teppa RJ, Ness RB, Crombleholme WR, Roberts JM. Free leptin is increased in normal pregnancy and further increased in preeclampsia. Metab Clin Exper. 2000;49:1043–1048
  22. Catov JM, Patrick TE, Powers RW, Ness RB, Harger G, Roberts JM. Maternal leptin across pregnancy in women with small-for-gestational-age infants. Am J Obstet Gynecol. 2007;196:e551–e558
  23. Jansson T, Powell TL. IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? – a review. Placenta. 2006;27(Suppl. A):S91–S97

PII: S0143-4004(08)00206-3

doi: 10.1016/j.placenta.2008.07.001

Placenta
Volume 29, Issue 10 , Pages 879-882 , October 2008

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