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Placenta
Volume 29, Issue 9
, Pages 772-783
, September 2008
Live and Let Die – Regulation of Villous Trophoblast Apoptosis in Normal and Abnormal Pregnancies
References
- . To be, or not to be, that is the question. Apoptosis in human trophoblast. Placenta. 2000;21(1):1–13
- . Apoptosis in gestational trophoblastic disease is correlated with clinical outcome and Bcl-2 expression but not Bax expression. Mod Pathol. 1999;12(11):1025–1033
- . Apoptotic activity in gestational trophoblastic disease correlates with clinical outcome: assessment by the caspase-related M30 CytoDeath antibody. Histopathology. 2001;38(3):243–249
- . Placental apoptosis in preeclampsia. Obstet Gynecol. 2000;96(2):271–276
- . Increased placental apoptosis in pregnancies complicated by preeclampsia. Am J Obstet Gynecol. 2001;184(6):1249–1250
- . Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms. Int J Mol Med. 2005;16(1):79–84
- Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression. Am J Obstet Gynecol. 2002;186(5):1056–1061
- . Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro. Lab Invest. 1999;79(12):1687–1702
- . Viewpoint: putting the cell cycle in order. Science. 1996;274(5293):1643–1645
- . Cyclin dependent kinase regulation. Curr Opin Cell Biol. 1995;7(6):773–780
- . G1 events and regulation of cell proliferation. Science. 1989;246(4930):603–608
- . Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 1995;9(10):1149–1163
- . Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26(4):239–257
- . Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis. J Cell Biol. 1993;123(1):7–22
- . Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol. 1991;32:223–254
- . Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol. 1992;148(7):2207–2216
- . Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol. 2004;16(6):663–669
- . Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med. 2005;258(6):479–517
- . Caspases: the proteases of the apoptotic pathway. Oncogene. 1998;17(25):3237–3245
- Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998;94(3):325–337
- FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death—inducing signaling complex. Cell. 1996;85(6):817–827
- . A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 1998;391(6662):43–50
- . Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol. 2001;3(4):339–345
- Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol. 1999;144(2):281–292
- . Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem. 2001;276(10):7320–7326Epub 2000 Oct 31
- . Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998;94(4):481–490
- . Apoptosis. Life and death decisions. Science. 2003;299(5604):214–215
- . Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature. 1995;373(6513):438–441
- . Induction of apoptosis in mature T cells by tumour necrosis factor. Nature. 1995;377(6547):348–351
- . The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell. 1995;81(4):495–504
- . Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity. 2000;12(6):611–620
- . Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts. Placenta. 1994;15(8):819–835
- . DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature. 1998;394(6694):700–704
- . Apoptosis – the p53 network. J Cell Sci. 2003;116(Pt 20):4077–4085
- mdmx is a negative regulator of p53 activity in vivo. Cancer Res. 2002;62(11):3221–3225
- . Mdm2 promotes the rapid degradation of p53. Nature. 1997;387(6630):296–299
- . Nuclear exclusion of p53 in a subset of tumors requires MDM2 function. Oncogene. 2000;19(2):232–240
- . Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci U S A. 1986;83(14):5214–5218
- . The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. EMBO J. 1998;17(4):1029–1039
- . Toxic proteins released from mitochondria in cell death. Oncogene. 2004;23(16):2861–2874
- . Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochim Biophys Acta. 2004;1644(2–3):133–147
- . Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci U S A. 1997;94(10):5113–5118
- . Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature. 1999;399(6735):483–487
- Bcl-2 inhibits p53 nuclear import following DNA damage. Oncogene. 1997;15(23):2767–2772
- . XIAP: apoptotic brake and promising therapeutic target. Apoptosis. 2001;6(4):253–261
- . Survivin: a protein with dual roles in mitosis and apoptosis. Int Rev Cytol. 2005;247:35–88
- . Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J Biol Chem. 2004;279(39):40622–40628[Epub 2004 Jul 26]
- Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000;102(1):43–53
- . Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000;102(1):33–42
- . The loss of mdm2 induces p53-mediated apoptosis. Oncogene. 2000;19(13):1691–1697
- . Bcl-2 family members and disease. Biochim Biophys Acta. 2004;1644(2–3):169–177
- . Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 1995;378(6553):206–208
- . Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992;356(6366):215–221
- . Ultrastructure of the normal human placenta. Electron Microsc Rev. 1991;4:129–178
- . Apoptosis in the trophoblast—role of apoptosis in placental morphogenesis. J Soc Gynecol Investig. 2004;11(6):353–362
- . Trophoblast deportation in human pregnancy—its relevance for pre-eclampsia. Placenta. 1999;20(7):531–539
- . Syncytial fusion of human trophoblast depends on caspase 8. Cell Death Differ. 2004;11(1):90–98
- . Trophoblast differentiation modulates the activity of caspases in primary cultures of term human trophoblasts. Pediatr Res. 2002;52(3):411–415
- . Expression of a cytokeratin 18 neo-epitope is a specific marker for trophoblast apoptosis in human placenta. Placenta. 2001;22(1):44–48
- . Placental apoptosis in normal human pregnancy. Am J Obstet Gynecol. 1997;177(1):57–65
- . A reappraisal of the contrasting morphological appearances of villous cytotrophoblast cells during early human pregnancy; evidence for both apoptosis and primary necrosis. Placenta. 2003;24(4):297–305
- . Syncytial knots and intervillous bridges in the human placenta: an ultrastructural study. J Anat. 1977;124(2):275–286
- . An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia. Placenta. 1980;1(1):61–76
- . Placental apoptosis is increased in post-term pregnancies. Br J Obstet Gynaecol. 1999;106(8):861–862
- . A study of the incidence of apoptosis in the human placental cells in the last weeks of pregnancy. J Obstet Gynaecol. 2003;23(5):515–517
- . Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol. 2003;162(1):115–125
- . Expressions of proliferation markers (Ki-67, proliferating cell nuclear antigen, and silver-staining nucleolar organizer regions) and of p53 tumor protein in gestational trophoblastic disease. Am J Obstet Gynecol. 2001;184(4):567–574
- . The contribution of placental oxidative stress to early pregnancy failure. Hum Pathol. 2003;34(12):1265–1275
- . Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol. 2002;186(1):158–166
- . Increased placental apoptosis in intrauterine growth restriction. Am J Obstet Gynecol. 1997;177(6):1395–1401
- Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: a unique model of apoptosis within a syncytium. Placenta. 2000;21(4):361–366
- . The placenta in toxaemia of pregnancy. Am J Obstet Gynecol. 1940;39:1000–1005
- . Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species. Placenta. 2007;28(Suppl 1):S33–S40
- . Altered cell kinetics in cultured placental villous explants in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. J Pathol. 2004;204(1):11–18
- . Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am J Pathol. 2003;162(2):637–643
- . Dissociation between increased apoptosis and expression of the tumor necrosis factor-alpha system in term placental villi with preeclampsia. Clin Biochem. 2006;39(6):646–651[Epub 2006 Feb 23]
- Immunohistochemical distribution of proteins belonging to the receptor-mediated and the mitochondrial apoptotic pathways in human placenta during gestation. Cell Tissue Res. 2004;318(3):599–608
- . Placental Fas and Fas ligand expression in normal early, term and molar pregnancy. Placenta. 2004;25(4):321–330
- . First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Mol Hum Reprod. 2004;10(1):55–63
- . Endogenous tumor necrosis factor alpha mediates enhanced apoptosis of cultured villous trophoblasts from intrauterine growth-restricted placentae. Reproduction. 2007;133(1):257–264
- . Expression of the p53 tumour suppressor gene in human placenta: an immunohistochemical study. Placenta. 1995;16:101–114
- C-myc and tumour suppressor gene product expression in developing and term human trophoblast. Placenta. 1994;15(4):399–409
- Differentiation-dependent expression of the BCL-2 proto-oncogene in the human trophoblast lineage. J Soc Gynecol Investig. 1994;1(2):164–172
- . Oncogene and tumour suppressor gene products during trophoblast differentiation in the first trimester. Mol Hum Reprod. 1998;4(5):477–481
- . Immunohistochemical evidence of p53 protein in human placenta and choriocarcinoma cell lines. Hum Reprod. 1995;10(4):983–988
- Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours. Br J Cancer. 1996;73(10):1216–1219
- Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational trophoblastic disease: correlation with mdm2, proliferation index, and clinicopathologic parameters. Int J Gynecol Cancer. 1999;9(2):123–130
- . p53, p21, Rb and mdm2 oncoproteins. Expression in normal placenta, partial and complete mole, and choriocarcinoma. J Reprod Med. 1998;43(2):119–127
- . Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast. Placenta. 2008;29(2):175–186
- . Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation. Mol Hum Reprod. 1999;5(3):246–251
- Expression and distribution of notch protein members in human placenta throughout pregnancy. Placenta. 2007;28(2–3):118–126
- . Proteomic profiling of forskolin-induced differentiated BeWo cells: an in-vitro model of cytotrophoblast differentiation. Reprod Biomed Online. 2007;14(4):477–487
- . Identification of novel p53-binding proteins by biomolecular interaction analysis combined with tandem mass spectrometry. Mol Biotechnol. 2003;23(3):203–212
- . Location of cell cycle regulators cyclin B1, cyclin A, PCNA, Ki67 and cell cycle inhibitors p21, p27 and p57 in human first trimester placenta and deciduas. Histochem Cell Biol. 2006;125(6):615–624
- Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, Cyclin E, p27(kip1), and Ki-67 in normal placenta and gestational trophoblastic disease. Mod Pathol. 2001;14(10):1036–1042
- . Expression patterns of the cell-cycle inhibitor p27 and the cell-cycle promoter cyclin E in the human placenta throughout gestation: implications for the control of proliferation. Placenta. 1999;20(5–6):401–406
- . Cytotoxic effect of zinc-citrate compound on choriocarcinoma cell lines. Placenta. 2007;28(1):22–30[Epub 2006 Feb 28]
- . Effect of maternal age on indices of apoptotic and proliferative cells in trophoblasts of full-term placenta. Mol Hum Reprod. 2001;7(12):1179–1185
- Expression of proliferation and apoptotic markers in human placenta during pregnancy. Acta Histochem. 2002;104(4):335–338
- The immunolocalization of Bcl-2 in human term placenta. Clin Exp Obstet Gynecol. 2001;28(3):144–147
- . Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta. Histochem Cell Biol. 1998;110(5):495–508
- . Enhanced basal apoptosis in cultured term human cytotrophoblasts is associated with a higher expression and physical interaction of p53 and Bak. Placenta. 2006;27(9–10):978–983[Epub 2005 Dec 27]
- The expression of apoptosis related genes in the first trimester human placenta using a short term in vitro model. Apoptosis. 2005;10(1):135–140
- . p53, Bax and Bcl-2 expression, and apoptosis in gestational trophoblast of complete hydatidiform mole. Placenta. 1998;19(5–6):361–369
- A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. Cell Death Differ. 2005;12(5):441–452
- . Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. Eur J Obstet Gynecol Reprod Biol. 2005;122(2):172–176
- . Temporal and spatial patterns of expression of inhibitors of apoptosis in human placentas. Am J Pathol. 2003;163(2):413–422
- . Survivin inhibits apoptosis in cytotrophoblasts. Placenta. 2003;24(1):65–76
- . X-linked inhibitor of apoptosis protein expression and the regulation of apoptosis during human placental development. Biol Reprod. 2001;64(4):1264–1272
- XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway. J Biol Chem. 2007;282(17):13059–13072[Epub 2007 Feb 28]
- . Altered expression of regulators of caspase activity within trophoblast of normal and pre-eclamptic pregnancies. Reprod Sci. 2007;14(1):266A
- . Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res. 2002;90(12):1274–1281
- Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation. Placenta. 2003;24(2–3):181–190
- . The influence of oxygen and tumor necrosis factor-alpha on the cellular kinetics of term placental villous explants in culture. J Histochem Cytochem. 2004;52(6):749–757
- . Caspase-14 expression in the human placenta. Reprod Biomed Online. 2005;11(2):236–243
- Expression of the proliferation marker Ki-67 and of p53 tumor protein in trophoblastic tissue of preeclamptic, HELLP, and intrauterine growth-restricted pregnancies. Int J Gynecol Pathol. 2006;25(4):354–360
- Changes in apoptosis and Bcl-2 expression in human hyperglycemic, term placental trophoblast. Diabetes Res Clin Pract. 2006;73(2):143–149[Epub 2006 Mar 24]
- Hypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsia. Am J Pathol. 2007;171(2):496–506
- . Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor. Am J Physiol Cell Physiol. 2000;278(5):C982–C988
- . Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast. Placenta. 2008 Feb;29(2):175–186[Epub 2007 Dec 21]
- . Altered Bcl-2 and Bax expression is associated with cultured first trimester human cytotrophoblasts apoptosis induced by hypoxia. Life Sci. 2006;79(4):351–355[Epub 2006 Feb 24]
- Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction. Placenta. 2006;27(1):56–61[Epub 2005 Jan 25]
- . Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies. Br J Obstet Gynaecol. 1998;105(6):632–640
- . The levels of circulatory cell free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia. Hypertens Pregnancy. 2002;21(1):77–83
- . An in vitro model of human placental trophoblast deportation/shedding. Mol Hum Reprod. 2006;12(11):687–694[Epub 2006 Sep 20]
- . Hypoxia-induced membrane-bound apoptotic DNA particles: potential mechanism of fetal DNA in maternal plasma. Ann N Y Acad Sci. 2006;1075:57–62
- . Trophoblastic oxidative stress and the release of cell-free feto-placental DNA. Am J Pathol. 2006;169(2):400–404
- . The effects of apoptotic, deported human placental trophoblast on macrophages: possible consequences for pregnancy. J Reprod Immunol. 2006;72(1–2):33–45[Epub 2006 Jul 14]
- . Trophoblast deportation and the maternal inflammatory response in pre-eclampsia. J Reprod Immunol. 2003;59(2):153–160
- . Occurrence of neutrophil extracellular DNA traps (NETs) in pre-eclampsia: a link with elevated levels of cell-free DNA?. Ann N Y Acad Sci. 2006;1075:118–122
- A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells. Placenta. 2005;26(1):59–66
- Effect of syncytiotrophoblast microvillous membrane treatment on gene expression in human umbilical vein endothelial cells. BJOG. 2006;113(11):1270–1279
- . Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function. Br J Obstet Gynaecol. 1997;104(2):235–240
- Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol. 2006;291(4):R1085–R1093
- Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006;355(10):992–1005
- . Microparticles shed from human placenta contain anti-fibrinolytic and anti-angiogenic compounds: implications in pre-eclampsia. Reprod Sci. 2007;14(Suppl 1):219A
- . In vitro differentiation of villous trophoblasts from pregnancies complicated by intrauterine growth restriction with and without pre-eclampsia. Placenta. 2007;28(10):999–1003
PII: S0143-4004(08)00208-7
doi: 10.1016/j.placenta.2008.07.003
© 2008 Elsevier Ltd. All rights reserved.
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Placenta
Volume 29, Issue 9
, Pages 772-783
, September 2008
