Placenta
Volume 29, Issue 10 , Pages 905-909 , October 2008

Angiotensin II Type 1 Receptor Has Impact on Murine Placentation

  • T. Walther

      Affiliations

    • Department of Cardiology and Pneumology, Charité, Campus Benjamin Franklin, Berlin, Germany
    • Biomedical Sciences, Hull York Medical School, University of Hull, Hull, UK
    • Corresponding Author InformationCorresponding author. Charité, Campus Benjamin Franklin (CBF), Department of Cardiology and Pneumology, Hindenburgdamm 30, 12200 Berlin, Germany. Tel.: +49 30 8445 4258; fax: +49 30 8445 4648.
    • ,
  • A. Jank

      Affiliations

    • Department of Obstetrics, University of Leipzig, Leipzig, Germany
    • ,
  • S. Heringer-Walther

      Affiliations

    • Department of Cardiology and Pneumology, Charité, Campus Benjamin Franklin, Berlin, Germany
    • Department of Obstetrics, University of Leipzig, Leipzig, Germany
    • ,
  • L.-C. Horn

      Affiliations

    • Department of Pathology, University of Leipzig, Leipzig, Germany
    • ,
  • H. Stepan

      Affiliations

    • Department of Obstetrics, University of Leipzig, Leipzig, Germany

,Accepted 4 July 2008.

References 

  1. Takimoto E, Ishida J, Sugiyama F, Horiguchi H, Murakami K, Fukamizu A. Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen. Science. 1996;274:995–998
  2. Saito T, Ishida J, Takimoto-Ohnishi E, Takamine S, Shimizu T, Sugaya T, et al. An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation. FASEB J. 2004;18:388–390
  3. Wallukat G, Homuth V, Fischer T, Lindschau C, Horstkamp B, Jupner A, et al. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest. 1999;103:945–952
  4. Walther T, Wallukat G, Jank A, Bartel S, Schultheiss HP, Faber R, et al. The angiotensin II AT1 receptor autoimmune antibody reflects fundamental alterations of the utero-placental vasculature. Hypertension. 2005;46:1275–1279
  5. Shaw DM. Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol. 2005;288:F614–F625
  6. Herse F, Dechend R, Harsem NK, Wallukat G, Janke J, Qadri F, et al. Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia. Hypertension. 2007;49:604–611
  7. Ito M, Oliverio MI, Mannon PJ, Best CF, Maeda N, Smithies O, et al. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci USA. 1995;92:3521–3525
  8. Seidal T, Balaton AJ, Battifora H. Interpretation and quantification of immunostains. Am J Surg Pathol. 2001;25(9):1204–1207
  9. O'Leary TJ. Standardization in immunohistochemistry. Appl Immunohistochem Mol Morphol. 2001;9(1):3–8
  10. Nielsen AH, Schauser KH, Poulsen K. Current topic: the uteroplacental renin-angiotensin system. Placenta. 2000;21:468–477
  11. Xia Y, Wen HY, Kellems RE. Angiotensin II inhibits human trophoblast invasion through AT1 receptor activation. J Biol Chem. 2002;277:24601–24608
  12. Dechend R, Viedt C, Muller DN, Ugele B, Brandes RP, Wallukat G, et al. AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation. 2003;107:1632–1639
  13. Thway TM, Shlykov SG, Day MC, Sanborn BM, Gilstrap LC, Xia Y, et al. Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activation. Circulation. 2004;110:1612–1619
  14. Rosenthal T, Oparil S. The effect of antihypertensive drugs on the fetus. J Hum Hypertens. 2002;16:293–298
  15. Li X, Shams M, Zhu J, Khalig A, Wilkes M, Whittle M, et al. Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants. J Clin Invest. 1998;15:442–454
  16. Cooper AC, Robinson G, Vinson GP, Cheung WT, Broughton Pipkin F. The localization and expression of the renin-angiotensin system in the human placenta throughout pregnancy. Placenta. 1999;20:467–474
  17. Tower C, Chappell S, Acharya M, Crane R, Szolin S, Symonds L, et al. Altered transmission of maternal angiotensin II receptor haplotypes in fetal growth restriction. Hum Mutat. 2006;27:138–144
  18. Caniggia I, Grisaru-Gravnosky S, Kuliszewsky M, Post M, Lye SJ. Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies. J Clin Invest. 1999;103:1641–1650

PII: S0143-4004(08)00211-7

doi: 10.1016/j.placenta.2008.07.006

Placenta
Volume 29, Issue 10 , Pages 905-909 , October 2008

Article Tools

* Image Usage & Resolution