Placenta
Volume 29, Issue 10 , Pages 855-861 , October 2008

The C5b-9 Membrane Attack Complex of Complement Activation Localizes to Villous Trophoblast Injury in vivo and Modulates Human Trophoblast Function in vitro

  • R. Rampersad

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University, Campus Box 8064, 4566 Scott Avenue, Saint Louis, MO 63110, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 314 747 1380; fax: +1 314 747 1720.
    • ,
  • A. Barton

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University, Campus Box 8064, 4566 Scott Avenue, Saint Louis, MO 63110, USA
    • ,
  • Y. Sadovsky

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University, Campus Box 8064, 4566 Scott Avenue, Saint Louis, MO 63110, USA
    • Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA
    • ,
  • D.M. Nelson

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University, Campus Box 8064, 4566 Scott Avenue, Saint Louis, MO 63110, USA

,Accepted 22 July 2008.

References 

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  2. Tjoa ML, Cindrova-Davies T, Spasic-Boskovic O, Bianchi DW, Burton GJ. Trophoblastic oxidative stress and the release of cell-free feto-placental DNA. Am J Pathol. 2006;169:400–404
  3. Hung TH, Charnock-Jones DS, Skepper JN, Burton GJ. Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. Am J Pathol. 2004;164:1049–1061
  4. Nelson DM, Crouch EC, Curran EM, Farmer DR. Trophoblast interaction with fibrin matrix. Epithelialization of perivillous fibrin deposits as a mechanism for villous repair in the human placenta. Am J Pathol. 1990;136:855–865
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  21. Hu C, Smith SD, Pang L, Sadovsky Y, Nelson DM. Enhanced basal apoptosis in cultured term human cytotrophoblasts is associated with a higher expression and physical interaction of p53 and bak. Placenta. 2006;27:978–983
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PII: S0143-4004(08)00220-8

doi: 10.1016/j.placenta.2008.07.008

Placenta
Volume 29, Issue 10 , Pages 855-861 , October 2008

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