Placenta
Volume 29 , Pages 126-128 , October 2008

Chromosomal Abnormalities in Miscarriages after Different Assisted Reproduction Procedures

  • D. Bettio

      Affiliations

    • Cytogenetic and Medical Genetic Laboratory, Operative Unit of Clinical Investigations, IRCCS Humanitas Clinical Institute, Via Manzoni, 56, 20089 Rozzano, Milan, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 02 82244720; fax: +39 02 82244790.
    • ,
  • A. Venci

      Affiliations

    • Cytogenetic and Medical Genetic Laboratory, Operative Unit of Clinical Investigations, IRCCS Humanitas Clinical Institute, Via Manzoni, 56, 20089 Rozzano, Milan, Italy
    • ,
  • P.E. Levi Setti

      Affiliations

    • Operative Unit of Reproductive Medicine, IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy

,Accepted 14 August 2008.

References 

  1. Hassold TJ. A cytogenetic study of repeated spontaneous abortions. Am J Med Genet. 1980;32:723–730
  2. Kalousek DK, Lau AE. Pathology of spontaneous abortion. In:  Dimmick JE,  Kalousek DK editor. Developmental pathology of the embryo and fetus. Philadelphia: Lippincott; 1992;p. 55–82
  3. Reddy KS. Double trisomy in spontaneous abortions. Hum Genet. 1997;101:339–345
  4. Golubovsky MD. Postzygotic diploidization of triploids as a source of unusual cases of mosaicism, chimerism and twinning. Hum Reprod. 2003;18:236–242[Review]
  5. Simoni G, Brambati B, Danesino C, Rossella F, Terzoli GL, Ferrari M, et al. Efficient direct chromosome analyses and enzyme determinations from chorionic villi samples in the first trimester of pregnancy. Hum Genet. 1983;64:349–357
  6. Guerneri S, Bettio D, Simoni G, Brambati B, Lanzani A, Fraccaro M. Prevalence and distribution of chromosome abnormalities in a sample of first trimester internal abortions. Hum Reprod. 1987;2:735–739
  7. Nagishi M, Yamamoto T, Iinuma K, Shimomura K, Berend SA, Knops J. Chromosome abnormalities identified in 347 spontaneous abortions collected in Japan. J Obstet Gynaecol Res. 2004;30:237–241
  8. Yusuf RZ, Naeem R. Cytogenetic abnormalities in products of conception: a relationship revisited. Am J Reprod Immunol. 2004;52:88–96
  9. Morales C, Sanchez A, Bruguera J, Margarit E, Borrell A, Borobio V, et al. Cytogenetic study of spontaneous abortions using semi-direct analysis of chorionic villi samples detects the broadest spectrum of chromosome abnormalities. Am J Med Genet A. 2008;146:66–70
  10. Bell KA, Van Deerlin PG, Haddad BR, Feinberg RF. Cytogenetic diagnosis of “normal 46,XX” karyotypes in spontaneous abortions frequently may be misleading. Fertil Steril. 1999;71:334–341
  11. Devroey P, Van Steirteghem A. A review of ten years experience of ICSI. Hum Reprod Update. 2004;10:19–28[Review]
  12. Causio F, Fischetto R, Sarcina E, Geusa S, Tartagni M. Chromosome analysis of spontaneous abortions after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Eur J Obstet Gynecol Reprod Biol. 2002;105:44–48
  13. Lathi RB, Milki AA. Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril. 2004;81:1270–1272
  14. Ma S, Philipp T, Zhao Y, Stetten G, Robinson WP, Kalousek D. Frequency of chromosomal abnormalities in spontaneous abortions derived from intracytoplasmatic sperm injection compared with those from in vitro fertilization. Fertil Steril. 2006;85:236–238
  15. Hewitson LC, Simerly CR, Schatten G. Cytoplasmic endowment of organelles other than mitochondria. In:  Jansen R,  Mortimer D editor. Towards reproductive certainty: fertility and genetics beyond. New York: Parthenon Publishing Group; 1999;
  16. Silber S, Escudero T, Lenahan K, Abdelhadi I, Kilani Z, Munné S. Chromosomal abnormalities in embryos derived from testicular sperm extraction. Fertil Steril. 2003;79:30–38

PII: S0143-4004(08)00261-0

doi: 10.1016/j.placenta.2008.08.015

Placenta
Volume 29 , Pages 126-128 , October 2008

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