Placenta
Volume 29, Issue 12 , Pages 1034-1040 , December 2008

Screening for Placental Insufficiency in High-risk Pregnancies: Is Earlier Better?

  • S.L. Costa

      Affiliations

    • Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
  • ,
  • L. Proctor

      Affiliations

    • Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
  • ,
  • J.M. Dodd

      Affiliations

    • Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    • Discipline of Obstetrics and Gynecology, The University of Adelaide, Adelaide, South Australia, Australia
  • ,
  • M. Toal

      Affiliations

    • Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
  • ,
  • N. Okun

      Affiliations

    • Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
  • ,
  • J.-A. Johnson

      Affiliations

    • Department of Obstetrics and Gynecology, University of Calgary, Alberta, Canada
  • ,
  • R. Windrim

      Affiliations

    • Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
  • ,
  • J.C.P. Kingdom

      Affiliations

    • Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    • Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding author. Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, ON M5G 1X5, Canada. Tel.: +1 416 586 8764; fax: +1 416 586 8565.

,Accepted 5 September 2008.

References 

  1. Viero S, Chaddha V, Alkazaleh F, Simchen MJ, Malik A, Kelly E, et al. Prognostic value of placental ultrasound in pregnancies complicated by absent end-diastolic flow velocity in the umbilical arteries. Placenta. 2004;25:735–741
  2. Moldenhauer JS, Stanek J, Warshak C, Khoury J, Sibai B. The frequency and severity of placental findings in women with preeclampsia are gestational age dependent. Am J Obstet Gynecol. 2003;189:1173–1177
  3. Nordenvall M, Ullberg U, Laurin J, Lingman G, Sandstedt B, Ulmsten U. Placental morphology in relation to umbilical artery blood velocity waveforms. Eur J Obstet Gynecol Reprod Biol. 1991;40:179–190
  4. Toal M, Keating S, Machin G, Dodd J, Adamson SL, Windrim RC, et al. Determinants of adverse perinatal outcome in high-risk women with abnormal uterine artery Doppler images. Am J Obstet Gynecol. 2008;198(330):e1–e7
  5. Krebs C, Macara LM, Leiser R, Bowman AW, Greer IA, Kingdom JC. Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am J Obstet Gynecol. 1996;175:1534–1542
  6. Cnossen JS, Morris RK, ter Riet G, Mol BW, van der Post JA, Coomarasamy A, et al. Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ. 2008;178:701–711
  7. Pardi G, Cetin I, Marconi AM, Bozzetti P, Buscaglia M, Makowski EL, et al. Venous drainage of the human uterus: respiratory gas studies in normal and fetal growth-retarded pregnancies. Am J Obstet Gynecol. 1992;166:699–706
  8. Waller DK, Lustig LS, Cunningham GC, Golbus MS, Hook EB. Second-trimester maternal serum alpha-fetoprotein levels and the risk of subsequent fetal death. N Engl J Med. 1991;325:6–10
  9. Lepage N, Chitayat D, Kingdom J, Huang T. Association between second-trimester isolated high maternal serum human chorionic gonadotropin levels and obstetric complications in singleton and twin pregnancies. Am J Obstet Gynecol. 2003;188:1354–1359
  10. Whittle W, Chaddha V, Wyatt P, Huppertz B, Kingdom J. Ultrasound detection of placental insufficiency in women with ‘unexplained’ abnormal maternal serum screening results. Clin Genet. 2006;69:97–104
  11. Toal M, Chan C, Fallah S, Alkazaleh F, Chaddha V, Windrim RC, et al. Usefulness of a placental profile in high-risk pregnancies. Am J Obstet Gynecol. 2007;196(363):e1–e7
  12. Metzenbauer M, Hafner E, Hoefinger D, Schuchter K, Stangl G, Ogris E, et al. Three-dimensional ultrasound measurement of the placental volume in early pregnancy: method and correlation with biochemical placenta parameters. Placenta. 2001;22:602–605
  13. Martin AM, Bindra R, Curcio P, Cicero S, Nicolaides KH. Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11–14 weeks of gestation. Ultrasound Obstet Gynecol. 2001;18:583–586
  14. Kagan KO, Wright D, Valencia C, Maiz N, Nicolaides KH. Screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free beta-hCG and pregnancy-associated plasma protein-A. Hum Reprod. 2008;23:1968–1975
  15. Smith GC, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor JM. Early pregnancy levels of pregnancy-associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metab. 2002;87:1762–1767
  16. Dugoff L, Hobbins JC, Malone FD, Porter TF, Luthy D, Comstock CH, et al. First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial). Am J Obstet Gynecol. 2004;191:1446–1451
  17. Bower S, Bewley S, Campbell S. Improved prediction of preeclampsia by two-stage screening of uterine arteries using the early diastolic notch and color Doppler imaging. Obstet Gynecol. 1993;82:78–83
  18. Jauniaux E, Moscoso G, Campbell S, Gibb D, Driver M, Nicolaides KH. Correlation of ultrasound and pathologic findings of placental anomalies in pregnancies with elevated maternal serum alpha-fetoprotein. Eur J Obstet Gynecol Reprod Biol. 1990;37:219–230
  19. Kramer MS, Platt RW, Wen SW, Joseph KS, Allen A, Abrahamowicz M, et al. A new and improved population-based Canadian reference for birth weight for gestational age. Pediatrics. 2001;108:E35
  20. ACOG Practice Bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 2002;77:67–75
  21. Krantz D, Goetzl L, Simpson JL, Thom E, Zachary J, Hallahan TW, et al. Association of extreme first-trimester free human chorionic gonadotropin-beta, pregnancy-associated plasma protein A, and nuchal translucency with intrauterine growth restriction and other adverse pregnancy outcomes. Am J Obstet Gynecol. 2004;191:1452–1458
  22. Smith GC, Crossley JA, Aitken DA, Pell JP, Cameron AD, Connor JM, et al. First-trimester placentation and the risk of antepartum stillbirth. JAMA. 2004;292:2249–2254
  23. Brownbill P, Edwards D, Jones C, Mahendran D, Owen D, Sibley C, et al. Mechanisms of alphafetoprotein transfer in the perfused human placental cotyledon from uncomplicated pregnancy. J Clin Invest. 1995;96:2220–2226
  24. Smith GC, Shah I, Crossley JA, Aitken DA, Pell JP, Nelson SM, et al. Pregnancy-associated plasma protein A and alpha-fetoprotein and prediction of adverse perinatal outcome. Obstet Gynecol. 2006;107:161–166
  25. Hempstock J, Jauniaux E, Greenwold N, Burton GJ. The contribution of placental oxidative stress to early pregnancy failure. Hum Pathol. 2003;34:1265–1275
  26. Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 2003;69:1–7
  27. Schaaps JP, Tsatsaris V, Goffin F, Brichant JF, Delbecque K, Tebache M, et al. Shunting the intervillous space: new concepts in human uteroplacental vascularization. Am J Obstet Gynecol. 2005;192:323–332
  28. Kingdom JC, Kaufmann P. Oxygen and placental villous development: origins of fetal hypoxia. Placenta. 1997;18:613–621[discussion 623–6]
  29. Nevo O, Soleymanlou N, Wu Y, Xu J, Kingdom J, Many A, et al. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1085–R1093
  30. Benirschke K, Kaufmann P, Baergen R. Early development of the human placenta. New York, NY: Springer; 2006;
  31. Fisk NM, MacLachlan N, Ellis C, Tannirandorn Y, Tonge HM, Rodeck CH. Absent end-diastolic flow in first trimester umbilical artery. Lancet. 1988;2:1256–1257
  32. Guibourdenche J, Frendo JL, Pidoux G, Bertin G, Luton D, Muller F, et al. Expression of pregnancy-associated plasma protein-A (PAPP-A) during human villous trophoblast differentiation in vitro. Placenta. 2003;24:532–539
  33. Sun IY, Overgaard MT, Oxvig C, Giudice LC. Pregnancy-associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membrane. J Clin Endocrinol Metab. 2002;87:5235–5240
  34. Laursen LS, Kjaer-Sorensen K, Andersen MH, Oxvig C. Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5. Mol Endocrinol. 2007;21:1246–1257
  35. Conover CA, Mason MA, Levine JA, Novak CM. Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype. J Endocrinol. 2008;198:599–605
  36. Pilalis A, Souka AP, Antsaklis P, Daskalakis G, Papantoniou N, Mesogitis S, et al. Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11–14 weeks' gestation. Ultrasound Obstet Gynecol. 2007;29:135–140
  37. Proctor L, Toal M, Keating S, Okun N, Windrim R, Smith G, et al. Prediction of adverse pregnancy outcomes in women with low pregnancy-associated plasma protein A. Abstracts of Perinatal Medicine 2008. June 2–4, 2008. Arch Dis Child Fetal Neonatal Ed. 2008;93(Suppl. 1):Fa41
  38. Dodd JM, Sahi K, McLeod A, Windrim RC, Kingdom JP. Heparin therapy for complications of placental dysfunction: a systematic review of the literature. Acta Obstet Gynecol Scand. 2008;87:804–811

PII: S0143-4004(08)00306-8

doi: 10.1016/j.placenta.2008.09.004

Placenta
Volume 29, Issue 12 , Pages 1034-1040 , December 2008