Long-term Forskolin Stimulation Induces AMPK Activation and Thereby Enhances Tight Junction Formation in Human Placental Trophoblast BeWo Cells

Egawa, M.; Kamata, H.; Kushiyama, A.; Sakoda, H.; Fujishiro, M.; Horike, N.; Yoneda, M.; Nakatsu, Y.; Ying, Guo; Jun, Zhang; Tsuchiya, Y.; Takata, K.; Kurihara, H.; Asano, T.

doi:10.1016/j.placenta.2008.09.008

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Volume 29, Issue 12 , Pages 1003-1008, December 2008

Long-term Forskolin Stimulation Induces AMPK Activation and Thereby Enhances Tight Junction Formation in Human Placental Trophoblast BeWo Cells

M. Egawa
- Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan
H. Kamata
- Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan
A. Kushiyama
- The Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Tiyoda-ku, Tokyo 100-0005, Japan
H. Sakoda
- Department of Internal Medicine, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
M. Fujishiro
- Department of Internal Medicine, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
N. Horike
- Department of Physiological Chemistry and Metabolism, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
M. Yoneda
- Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan
Y. Nakatsu
- Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan
Guo Ying
- Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan
Zhang Jun
- Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan
Y. Tsuchiya
- Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan
K. Takata
- Department of Cell Biology, Institute for Cellular and Molecular Regulation, Gunma University, 3-39-15 Showamachi, Maebashi, Gunma 371-8512, Japan
H. Kurihara
- Department of Physiological Chemistry and Metabolism, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
T. Asano
- Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan
- Corresponding author. Tel.: +81 82 257 5135; fax: +81 82 257 5136.