Placenta
Volume 30, Issue 1 , Pages 35-40 , January 2009

Expression Patterns of Two Serine Protease HtrA1 Forms in Human Placentas Complicated by Preeclampsia with and without Intrauterine Growth Restriction

  • T. Lorenzi

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto, 10/a, I-60020 Ancona, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 071 2206270; fax: +39 071 2206087.
  • ,
  • D. Marzioni

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto, 10/a, I-60020 Ancona, Italy
  • ,
  • S. Giannubilo

      Affiliations

    • Institute of Maternal and Infantile Sciences, Polytechnic University of Marche, Salesi Hospital, 60123 Ancona, Italy
  • ,
  • A. Quaranta

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto, 10/a, I-60020 Ancona, Italy
  • ,
  • C. Crescimanno

      Affiliations

    • Institute of Sciences of Formation, Kore University of Enna, 94100 Enna, Italy
  • ,
  • A. De Luca

      Affiliations

    • Department of Medicine and Public Health, Human Anatomy, Second University of Naples, 80138 Naples, Italy
  • ,
  • A. Baldi

      Affiliations

    • Department of Biochemistry “F. Cedrangolo”, Section of Pathologic Anatomy, Second University of Naples, 80138 Naples, Italy
  • ,
  • T. Todros

      Affiliations

    • Department of Obstetrics and Gynecology, University of Turin, 10126 Turin, Italy
  • ,
  • A.L. Tranquilli

      Affiliations

    • Institute of Maternal and Infantile Sciences, Polytechnic University of Marche, Salesi Hospital, 60123 Ancona, Italy
  • ,
  • M. Castellucci

      Affiliations

    • Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto, 10/a, I-60020 Ancona, Italy

,Accepted 16 October 2008.

References 

  1. Mütze S, Rudnik-Schöneborn S, Zerres K, Rath W. Genes and the preeclampsia syndrome. J Perinat Med. 2008;36:38–58
  2. Baumwell S, Karumanchi SA. Pre-eclampsia: clinical manifestations and molecular mechanisms. Nephron Clin Pract. 2007;106:c72–c81
  3. Soleymanlou N, Jurisicova A, Wu Y, Chijiiwa M, Ray JE, Detmar J, et al. Hypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsia. Am J Pathol. 2007;171(2):496–506
  4. Cross JC. Placental function in development and desease. Reprod Fertil Dev. 2006;18:71–76
  5. Cross JC. The genetics of pree-eclampsia: a feto-placental or maternal problem?. Clin Genet. 2003;64:96–103
  6. Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 2003;69:1–7
  7. Meekins JW, Pijenborg R, Hanssens M, McFadyen IR, VanAsshe A. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclapmtic pregnancies. BJOG. 1994;101:669–674
  8. Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia. Am J Obstet Gynecol. 2006;195:40–49
  9. Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstet Gynecol. 2000;96:271–276
  10. Smith SC, Baker PN, Symonds EM. Increased placental apoptosis in intrauterine growth restriction. Am J Obstet Gynecol. 1997;177:1395–1405
  11. Heazell AEP, Moll SJ, Jones CJP, Baker PN, Crocker IP. Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species. Placenta. 2007;21:S33–S40
  12. Todros T, Sciarrone A, Piccoli E, Guiot C, Kaufmann P, Kingdom J. Umbilical Doppler waveforms and placental villous angiogenesis in pregnancies complicated by fetal growth restriction. Obstet Gynecol. 1999;93:499–503
  13. Clausen T, Southan C, Ehrmann M. The HtrA family of proteases: implications for protein composition and cell fate. Mol Cell. 2002;10:443–455
  14. Chien J, Aletti G, Baldi A, Catalano V, Muretto P, Keeney GL, et al. Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J Clin Invest. 2006;116:1994–2004
  15. De Luca A, De Falco M, Severino A, Campioni M, Santini D, Baldi F, et al. Distribution of the serine protease HtrA1 in normal human tissues. J Histochem Cytochem. 2003;51:1279–1284
  16. Nie G-Y, Li Y, Minoura H, Batten L, Ooi GT, Findlay JK, et al. A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation. Mol Hum Reprod. 2003;279–290
  17. De Luca A, De Falco M, Fedele V, Cobellis L, Mastrogiacomo A, Laforgia V, et al. The serine protease HtrA1 is upregulated in the human placenta during pregnancy. J Histochem Cytochem. 2004;52:885–892
  18. Baldi A, De Luca A, Morini M, Battista T, Felsani A, Baldi F, et al. The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells. Oncogene. 2002;21:6684–6688
  19. Grau S, Richards PJ, Kerr B, Hughes C, Caterson B, Williams AS, et al. The role of human HtrA1 in arthritic disease. J Biol Chem. 2006;281:6124–6129
  20. Bowden MA, Di Nezza-Cossens LA, Jobling T, Salamonsen LA, Nie G. Serine proteases HtrA1 and HtrA3 are down-regulated with increasing grades of human endometrial cancer. Gynecol Oncol. 2006;103:253–260
  21. Marzioni D, Quaranta A, Lorenzi T, Morroni M, Crescimanno C, De Nictolis M, et al. Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases. Histol Histopathol, in press.
  22. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science. 2005;308:1592–1594
  23. Todros T, Vasario E, Cardaropoli S. Preeclampsia as an infectious disease. Expert Rev Obstet Gynecol. 2007;2:735–741
  24. ACOG Practice Bulletin . Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 2002;77:67–75
  25. Nicolini U, Ferrazzi E, Molla R, Massa E, Cicognani G, Santarone M, et al. Accuracy of an average ultrasonic laboratory in measurements of fetal biparietal diameter, head circumference and abdominal circumference. J Perinat Med. 1986;14:101–107
  26. Bower S, Bewley S, Campbell S. Improved prediction of preeclampsia by two-stage screening of uterine arteries using the early diastolic notch and color Doppler imaging. Obstet Gynecol. 1993;82:78–83
  27. Todros T, Ronco G, Fianchino O, Rosso S, Gabrielli S, Valsecchi L, et al. Accuracy of the umbilical arteries Doppler flow velocity waveforms in detecting adverse perinatal outcomes in a high-risk population. Acta Obstet Gynecol Scand. 1996;75:113–119
  28. Parazzini F, Cortinovis I, Bortolus R, Fedele L. Standard di peso alla nascita in Italia. Ann Ostet Ginecol Med Perinat. 1991;CXII:203–246
  29. ACOG Practice Bulletin . Intrauterine growth restriction. Number 12. Washington, DC: American College of Obstetricians and Gynecologists; 2000;
  30. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254
  31. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London). 1970;227:680–685
  32. De Luca A, De Falco M, De Luca L, Penta R, Shridhar V, Baldi F, et al. Pattern of expression of HtrA1 during mouse development. J Histochem Cytochem. 2004;52:1609–1617
  33. Benirschke K, Benirschke K, Kaufmann P, Baergen RN. Pathology of the human placenta. 5th ed.. New York: Springer; 2006;
  34. Ajayi F, Kongoasa N, Gaffey T, Asmann YW, Watson WJ, Baldi A, et al. Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion. Am J Obstet Gynecol. 2008;199:557;e1--10
  35. Tocharus J, Tsuchiya A, Kajikawa M, Ueta Y, Oka C, Kawaichi M. Developmentally regulated expression of mouse htrA3 and its role as an inhibitor of TGF-β signalling. Dev Growth Differ. 2004;46:257–274
  36. Anunciado AN, Stubbs TM, Pepkowitz SH, Lazarchick J, Miller CM, Pilia P. Altered villous vessel fibronectin in preeclampsia. Am J Obstet Gynecol. 1987;156:898–900
  37. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol. 1989;161:1200–1204
  38. Dekker GA, Sibai BM. Eziology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol. 1998;179:1359–1375
  39. De Luca Brunori I, Battini L, Brunori E, Lenzi P, Paparelli A, Simonelli M, et al. Placental barrier breakage in preeclampsia: ultrastructural evidence. Eur J Obstet Gynecol Reprod Biol. 2005;118:182–189

PII: S0143-4004(08)00350-0

doi: 10.1016/j.placenta.2008.10.016

Placenta
Volume 30, Issue 1 , Pages 35-40 , January 2009