Placenta
Volume 30, Issue 2 , Pages 130-135 , February 2009

In Vitro Dual Perfusion of Human Placental Lobules as a Flow Phantom to Investigate the Relationship between Fetoplacental Flow and Quantitative 3D Power Doppler Angiography

  • N.W. Jones

      Affiliations

    • Nottingham University Hospitals NHS Trust, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, UK
    • Corresponding Author InformationCorresponding author. c/o secretary to George Bugg, C floor, Obstetrics and Gynaecology Department, Directorate of Family Health, Nottingham University Hospitals NHS Trust, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, UK. Tel.: +44 (0)1159 421416x66470; fax: +44 (0)1159 709086.
    • ,
  • E.S. Hutchinson

      Affiliations

    • Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    • ,
  • P. Brownbill

      Affiliations

    • Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    • ,
  • I.P. Crocker

      Affiliations

    • Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    • ,
  • D. Eccles

      Affiliations

    • GE Medical Systems, UK
    • ,
  • G.J. Bugg

      Affiliations

    • Nottingham University Hospitals NHS Trust, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, UK
    • ,
  • N.J. Raine-Fenning

      Affiliations

    • Nottingham University Hospitals NHS Trust, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, UK

,Accepted 3 November 2008.

References 

  1. Carter A. When is the maternal placental circulation established in man?. Placenta. 1997;18:83–87
  2. Huppertz B, Peeters L. Vascular biology in implantation and placentation. Angiogenesis. 2005;8:157–167
  3. Jauniaux E, Hempstock J, Greenwold N, Burton G. Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol. 2003;162:115–125
  4. Campbell S. Placental vasculature as visualized by 3D power Doppler angiography and 3D color Doppler imaging. Ultrasound Obstet Gynecol. 2007;30:917–920
  5. Pairleitner H, Steiner H, Hasenoehrl G, Staudach A. Three-dimensional power Doppler sonography: imaging and quantifying blood flow and vascularization. Ultrasound Obstet Gynecol. 1999;14:139–143
  6. Raine-Fenning N, Campbell B, Clewes J, Kendall N, Johnson I. The interobserver reliability of three-dimensional power Doppler data acquisition within the female pelvis. Ultrasound Obstet Gynecol. 2004;23:501–508
  7. Raine-Fenning N, Campbell B, Kendall N, Clewes J, Johnson I. Quantifying the changes in endometrial vascularity throughout the normal menstrual cycle with three-dimensional power Doppler angiography. Hum Reprod. 2004;19:330–338
  8. Raine-Fenning N, Campbell B, Kendall N, Clewes J, Johnson I. Endometrial and subendometrial perfusion are impaired in women with unexplained subfertility. Hum Reprod. 2004;19:2605–2614
  9. Naredo E, Collado P, Cruz A, Palop M, Cabero F, Richi P, et al. Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression. Arthritis Rheum. 2007;57:116–124
  10. Guiot C, Gaglioti P, Oberto M, Piccoli E, Rosato R, Todros T. Is three-dimensional power Doppler ultrasound useful in the assessment of placental perfusion in normal and growth-restricted pregnancies?. Ultrasound Obstet Gynecol. 2008;31:171–176
  11. Hafner T, Kurjak A, Funduk-Kurjak B, Bekavac I. Assessment of early chorionic circulation by three-dimensional power Doppler. J Perinat Med. 2002;30:33–39
  12. Merce L, Barco M, Bau S, Kupesic S, Kurjak A. Assessment of placental vascularization by three-dimensional power Doppler “vascular biopsy” in normal pregnancies. Croat Med J. 2005;46:765–771
  13. Rizzo G, Capponi A, Cavicchioni O, Vendola M, Arduini D. Placental vascularization measured by three-dimensional power Doppler ultrasound at 11 to 13+6weeks’ gestation in normal and aneuploid fetuses. Ultrasound Obstet Gynecol. 2007;30:259–262
  14. Yu C, Chang C, Ko H, Chen W, Chang F. Assessment of placental fractional moving blood volume using quantitative three-dimensional power Doppler ultrasound. Ultrasound Med Biol. 2003;29:19–23
  15. Zalud I, Shaha S. Evaluation of the utero-placental circulation by three-dimensional Doppler ultrasound in the second trimester of normal pregnancy. J Matern Fetal Neonatal Med. 2007;20:299–305
  16. Raine-Fenning N, Welsh A, Jones N, Bugg G. Methodological considerations for the correct application of quantitative three-dimensional power Doppler angiography. Ultrasound Obstet Gynecol. 2008;32:115–117(author reply 117–8)
  17. Welsh A. A caution regarding standardization of power Doppler to measure perfusion in placental tissue. Ultrasound Obstet Gynecol. 2008;31:111–112(author reply 112–3)
  18. Welsh A. Quantification of power Doppler and the index ’fractional moving blood volume’ (FMBV). Ultrasound Obstet Gynecol. 2004;23:323–326
  19. Dubiel M, Hammid A, Breborowicz A, Pietryga M, Sladkevicius P, Olofsson P, et al. Flow index evaluation of 3-D volume flow images: an in vivo and in vitro study. Ultrasound Med Biol. 2006;32:665–671
  20. Raine-Fenning NJ, Ramnarine KV, Nordin NM, Campbell BK. Quantification of blood perfusion using 3D power Doppler: an in-vitro flow phantom study. J Phys Conf Ser. 2004;1:181–186
  21. Schneider H, Panigel M, Dancis J. Transfer across the perfused human placenta of antipyrine, sodium and leucine. Am J Obstet Gynecol. 1972;114:822–828
  22. Brownbill P, Edwards D, Jones C, Mahendran D, Owen D, Sibley C, et al. Mechanisms of alphafetoprotein transfer in the perfused human placental cotyledon from uncomplicated pregnancy. J Clin Invest. 1995;96:2220–2226
  23. Brownbill P, Sibley C. Regulation of transplacental water transfer: the role of fetoplacental venous tone. Placenta. 2006;27:560–567
  24. Brownbill P, Bell N, Woods R, Lowry P, Page N, Sibley C. Neurokinin B is a paracrine vasodilator in the human fetal placental circulation. J Clin Endocrinol Metab. 2003;88:2164–2170
  25. Browne J, Ramnarine K, Watson A, Hoskins P. Assessment of the acoustic properties of common tissue-mimicking test phantoms. Ultrasound Med Biol. 2003;29:1053–1060
  26. Ramnarine K, Anderson T, Hoskins P. Construction and geometric stability of physiological flow rate wall-less stenosis phantoms. Ultrasound Med Biol. 2001;27:245–250
  27. Guimarães Filho H, da Costa L, Araújo Júnior E, Nardozza L, Nowak P, Moron A, et al. Placenta: angiogenesis and vascular assessment through three-dimensional power Doppler ultrasonography. Arch Gynecol Obstet. 2008;277:195–200
  28. Raine-Fenning N, Nordin N, Ramnarine K, Campbell B, Clewes J, Perkins A, et al. Determining the relationship between three-dimensional power Doppler data and true blood flow characteristics: an in-vitro flow phantom experiment. Ultrasound Obstet Gynecol. 2008;32:540–550
  29. Rubin J, Adler R, Fowlkes J, Spratt S, Pallister J, Che J, et al. Fractional moving blood volume: estimation with power Doppler US. Radiology. 1995;197:183–190
  30. Preidler K, Szolar D, Uggowitzer M, Stiskal M, Horina J. Technical note: comparison of colour Doppler energy sonography with conventional colour Doppler sonography in detection of flow signal in peripheral renal transplant vessels. Br J Radiol. 1995;68:1103–1105
  31. Raine-Fenning N, Nordin N, Ramnarine K, Campbell B, Clewes J, Perkins A, et al. Evaluation of the effect of machine settings on quantitative three-dimensional power Doppler angiography: an in-vitro flow phantom experiment. Ultrasound Obstet Gynecol. 2008;32:551–559
  32. Contractor S, Eaton B, Firth J, Bauman K. A comparison of the effects of different perfusion regimes on the structure of the isolated human placental lobule. Cell Tissue Res. 1984;237:609–617
  33. Challier J, Guerre-Millo M, Nandakumaran M, Gerbaut L, d'Athis P. Clearance of compounds of different molecular size in the human placenta in vitro. Biol Neonate. 1985;48:143–148
  34. Abramowicz J, Phillips D, Jessee L, Levene H, Parker K, Miller R. Sonographic investigation of flow patterns in the perfused human placenta and their modulation by vasoactive agents with enhanced visualization by the ultrasound contrast agent Albunex. J Clin Ultrasound. 1999;27:513–522
  35. Kaufmann P, Mayhew T, Charnock-Jones D. Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy. Placenta. 2004;25:114–126
  36. Kingdom J, Huppertz B, Seaward G, Kaufmann P. Development of the placental villous tree and its consequences for fetal growth. Eur J Obstet Gynecol Reprod Biol. 2000;92:35–43
  37. Macara L, Kingdom J, Kaufmann P, Kohnen G, Hair J, More I, et al. Structural analysis of placental terminal villi from growth-restricted pregnancies with abnormal umbilical artery Doppler waveforms. Placenta. 1996;17:37–48

PII: S0143-4004(08)00368-8

doi: 10.1016/j.placenta.2008.11.002

Placenta
Volume 30, Issue 2 , Pages 130-135 , February 2009

Article Tools

* Image Usage & Resolution