Placenta
Volume 30, Issue 2 , Pages 136-141 , February 2009

Decreased Umbilical Artery Compliance and IGF-I Plasma Levels in Infants with Intrauterine Growth Restriction – Implications for Fetal Programming of Hypertension

  • T. Burkhardt

      Affiliations

    • Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland
    • Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    • ,
  • C.M. Matter

      Affiliations

    • Cardiovascular Research, Institute of Physiology, University of Zurich and Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    • Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    • ,
  • C. Lohmann

      Affiliations

    • Cardiovascular Research, Institute of Physiology, University of Zurich and Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    • Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    • ,
  • H. Cai

      Affiliations

    • Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland
    • ,
  • T.F. Lüscher

      Affiliations

    • Cardiovascular Research, Institute of Physiology, University of Zurich and Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    • Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    • ,
  • A.H. Zisch

      Affiliations

    • Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland
    • Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    • ,
  • E. Beinder

      Affiliations

    • Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland
    • Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    • Corresponding Author InformationCorresponding author. Department of Obstetrics, Zurich University Hospital, Frauenklinikstrasse 10, CH-8091 Zurich, Switzerland. Tel.: +41 44 255 5148; fax: +41 44 255 4430.

,Accepted 7 November 2008.

References 

  1. Barker DJ, Bull AR, Osmond C, Simmonds SJ. Fetal and placental size and risk of hypertension in adult life. Bmj. 1990;301:259–262
  2. Schreuder MF, van Wijk JA. Delemarre-van de Waal HA. Intrauterine growth restriction increases blood pressure and central pulse pressure measured with telemetry in aging rats. J Hypertens. 2006;24:1337–1343
  3. Woods LL, Weeks DA. Naturally occurring intrauterine growth retardation and adult blood pressure in rats. Pediatr Res. 2004;56:763–767
  4. Barker DJ. In utero programming of chronic disease. Clin Sci (Lond). 1998;95:115–128
  5. Folkow B. Structure and function of the arteries in hypertension. Am Heart J. 1987;114:938–948
  6. Lehmann ED. Clinical value of aortic pulse-wave velocity measurement. Lancet. 1999;354:528–529
  7. Martyn CN, Barker DJ, Jespersen S, Greenwald S, Osmond C, Berry C. Growth in utero, adult blood pressure, and arterial compliance. Br Heart J. 1995;73:116–121
  8. Rucker RB, Tinker D. Structure and metabolism of arterial elastin. Int Rev Exp Pathol. 1977;17:1–47
  9. Martyn CN, Greenwald SE. Impaired synthesis of elastin in walls of aorta and large conduit arteries during early development as an initiating event in pathogenesis of systemic hypertension. Lancet. 1997;350:953–955
  10. Berk JL, Massoomi N, Hatch C, Goldstein RH. Hypoxia downregulates tropoelastin gene expression in rat lung fibroblasts by pretranslational mechanisms. Am J Physiol. 1999;277:L566–L572
  11. Foster JA, Miller ML, Benedict MR, Richmann RA, Rich CB. Evidence for insulin-like growth factor-I regulation of chick aortic elastogenesis. Matrix. 1989;9:328–335
  12. Wolfe BL, Rich CB, Goud HD, Terpstra AJ, Bashir M, Rosenbloom J, et al. Insulin-like growth factor-I regulates transcription of the elastin gene. J Biol Chem. 1993;268:12418–12426
  13. Foster JA, Rich CB, Miller M, Benedict MR, Richman RA, Florini JR. Effect of age and IGF-I administration on elastin gene expression in rat aorta. J Gerontol. 1990;45:B113–B118
  14. Hadlock F, Harrist R, Sharman R, Deter R, Park S. Estimation of fetal weight with the use of head, body and femur measurements: a prospective study. Am J Obstet Gynecol. 1985;151:333–337
  15. Kurmanavicius J, Florio I, Wisser J, Hebisch G, Zimmermann R, Muller R, et al. Reference resistance indices of the umbilical, fetal middle cerebral and uterine arteries at 24–42weeks of gestation. Ultrasound Obstet Gynecol. 1997;10:112–120
  16. Mulvany MJ. Procedures for investigation of small vessels using small vessel myograph. User Manual. Aarhus, Denmark: JP Trading; 1999.
  17. Adair GS, Davis HF, Partridge SM. A soluble protein derived from elastin. Nature. 1951;167:605
  18. Junek T, Baum O, Lauter H, Vetter K, Matejevic D, Graf R. Pre-eclampsia associated alterations of the elastic fibre system in umbilical cord vessels. Anat Embryol (Berl). 2000;201:291–303
  19. Pawlicka E, Bankowski E, Jaworski S. Elastin of the umbilical cord arteries and its alterations in EPH gestosis (preeclampsia). Biol Neonate. 1999;75:91–96
  20. Altman D. Practical statistics for medical research. London: Chapman & Hall; 1991;455pp.
  21. Voigt M, Friese K, Schneider K, Joch G, Hesse V. Short information about percentile values of body measures of new-born babies. Geburtsh Frauenheilk. 2002;62:274–276
  22. Greenwald SE. Ageing of the conduit arteries. J Pathol. 2007;211:157–172
  23. Parer JT. The effect of acute maternal hypoxia on fetal oxygenation and the umbilical circulation in the sheep. Eur J Obstet Gynecol Reprod Biol. 1980;10:125–136
  24. Künzel W. Die fetale Herz-Kreislauf-Reaktion auf akuten und chronischen Sauerstoffmangel. Der Gynäkologe. 1993;26:46–53
  25. Haan Jd. Umbilical artery flow velocity waveforms analysis and assessment of fetal oxygenation. Der Gynäkologe. 1993;26:29–34
  26. Laurent S, Boutouyrie P, Lacolley P. Structural and genetic bases of arterial stiffness. Hypertension. 2005;45:1050–1055
  27. Wolinsky H, Glagov S. A lamellar unit of aortic medial structure and function in mammals. Circ Res. 1967;20:99–111
  28. Dobrin PB. Mechanical properties of arteries. Physiol Rev. 1978;58:397–460
  29. Jacob MP, Badier-Commander C, Fontaine V, Benazzoug Y, Feldman L, Michel JB. Extracellular matrix remodeling in the vascular wall. Pathol Biol (Paris). 2001;49:326–332
  30. Keeley FW, Alatawi A. Response of aortic elastin synthesis and accumulation to developing hypertension and the inhibitory effect of colchicine on this response. Lab Invest. 1991;64:499–507
  31. Boumaza S, Arribas SM, Osborne-Pellegrin M, McGrath JC, Laurent S, Lacolley P, et al. Fenestrations of the carotid internal elastic lamina and structural adaptation in stroke-prone spontaneously hypertensive rats. Hypertension. 2001;37:1101–1107
  32. Cohuet G, Challande P, Osborne-Pellegrin M, Arribas SM, Dominiczak A, Louis H, et al. Mechanical strength of the isolated carotid artery in SHR. Hypertension. 2001;38:1167–1171
  33. Skilton MR, Evans N, Griffiths KA, Harmer JA, Celermajer DS. Aortic wall thickness in newborns with intrauterine growth restriction. Lancet. 2005;365:1484–1486
  34. Kinzler WL, Smulian JC, Kistler CA, Hahn RA, Zhou P, Gordon MK. Extracellular matrix changes in the umbilical arteries of growth-restricted fetuses. Am J Obstet Gynecol. 2005;192:1053–1059
  35. Wilhelm D, Mansmann U, Neudeck H, Matejevic D, Vetter K, Graf R. Decrease of elastic tissue fibres in stem villus blood vessels of the human placenta during IUGR and IUGR with concomitant pre-eclampsia. Anat Embryol (Berl). 2002;205:393–400
  36. Bersinger NA, Odegard RA. Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for-gestational age pregnancies. Acta Obstet Gynecol Scand. 2004;83:37–45
  37. Jensen DE, Rich CB, Terpstra AJ, Farmer SR, Foster JA. Transcriptional regulation of the elastin gene by insulin-like growth factor-I involves disruption of Sp1 binding. Evidence for the role of Rb in mediating Sp1 binding in aortic smooth muscle cells. J Biol Chem. 1995;270:6555–6563
  38. Meyer WW, Lind J. Iliac arteries in children with a single umbilical artery. Structure, calcifications, and early atherosclerotic lesions. Arch Dis Child. 1974;49:671–679
  39. Fonck EE. Prod'hom G, Roy S, Augsburger L, Rufenacht DA, Stergiopulos N. Effect of elastin degradation on carotid wall mechanics as assessed by a constituent-based biomechanical model. Am J Physiol Heart Circ Physiol. 2007;292:H2754–H2763

PII: S0143-4004(08)00377-9

doi: 10.1016/j.placenta.2008.11.005

Placenta
Volume 30, Issue 2 , Pages 136-141 , February 2009

Article Tools

* Image Usage & Resolution