Placenta
Volume 30, Issue 3 , Pages 226-235 , March 2009

Differential Placental Hormone Gene Expression during Pregnancy in a Transgenic Mouse Containing the Human Growth Hormone/Chorionic Somatomammotropin Locus

,Accepted 18 December 2008.

References 

  1. Chen EY, Liao YC, Smith DH, Barrera-Saldana HA, Gelinas RE, Seeburg PH. The human growth hormone locus: nucleotide sequence, biology, and evolution. Genomics. 1989;4:479–497
  2. Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, et al. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A. 1999;96:5129–5134
  3. Walker WH, Fitzpatrick SL, Barrera-Saldana HA, Resendez-Perez D, Saunders GF. The human placental lactogen genes: structure, function, evolution and transcriptional regulation. Endocr Rev. 1991;12:316–328
  4. Handwerger S, Freemark M. The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development. J Pediatr Endocrinol Metab. 2000;13:343–356
  5. Rygaard K, Revol A, Esquivel-Escobedo D, Beck BL, Barrera-Saldana HA. Absence of human placental lactogen and placental growth hormone (HGH-V) during pregnancy: PCR analysis of the deletion. Hum Genet. 1998;102:87–92
  6. Cattini PA, Yang X, Jin Y, Detillieux KA. Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression. Neuroendocrinology. 2006;83:145–153
  7. Goffin V, Shiverick KT, Kelly PA, Martial JA. Sequence–function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals. Endocr Rev. 1996;17:385–410
  8. West BL, Catanzaro DF, Mellon SH, Cattini PA, Baxter JD, Reudelhuber TL. Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element. Mol Cell Biol. 1987;7:1193–1197
  9. Behringer RR, Mathews LS, Palmiter RD, Brinster RL. Dwarf mice produced by genetic ablation of growth hormone-expressing cells. Genes Dev. 1988;2:453–461
  10. Jones BK, Monks BR, Liebhaber SA, Cooke NE. The human growth hormone gene is regulated by a multicomponent locus control region. Mol Cell Biol. 1995;15:7010–7021
  11. Su Y, Liebhaber SA, Cooke NE. The human growth hormone gene cluster locus control region supports position-independent pituitary- and placenta-specific expression in the transgenic mouse. J Biol Chem. 2000;275:7902–7909
  12. Kimura AP, Sizova D, Handwerger S, Cooke NE, Liebhaber SA. Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation. Mol Cell Biol. 2007;27:6555–6568
  13. Bennani-Baiti IM, Jones BK, Liebhaber SA, Cooke NE. Physical linkage of the human growth hormone gene cluster and the skeletal muscle sodium channel alpha-subunit gene (SCN4A) on chromosome 17. Genomics. 1995;29:647–652
  14. Bennani-Baiti IM, Cooke NE, Liebhaber SA. Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene. Genomics. 1998;48:258–264
  15. Surabhi RM, Bose S, Kuschak BC, Cattini PA. Physical linkage of the human growth hormone gene family and the thyroid hormone receptor interacting protein-1 gene on chromosome 17. Gene. 1998;212:67–75
  16. Surabhi RM, Daly LD, Cattini PA. Evidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI/SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17. Genome. 1999;42:545–549
  17. Jin Y, Surabhi RM, Fresnoza A, Lytras A, Cattini PA. A role for A/T-rich sequences and Pit-1/GHF-1 in a distal enhancer located in the human growth hormone locus control region with preferential pituitary activity in culture and transgenic mice. Mol Endocrinol. 1999;13:1249–1266
  18. Johnson W, Albanese C, Handwerger S, Williams T, Pestell RG, Jameson JL. Regulation of the human chorionic gonadotropin alpha- and beta-subunit promoters by AP-2. J Biol Chem. 1997;272:15405–15412
  19. LiCalsi C, Christophe S, Steger DJ, Buescher M, Fischer W, Mellon PL. AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin. Nucleic Acids Res. 2000;28:1036–1043
  20. Cheng YH, Handwerger S. AP-2alpha modulates human corticotropin-releasing hormone gene expression in the placenta by direct protein–protein interaction. Mol Cell Endocrinol. 2002;191:127–136
  21. Ozturk A, Donald LJ, Li L, Duckworth HW, Duckworth ML. Proteomic identification of AP2 gamma as a rat placental lactogen II trophoblast cell-specific enhancer binding protein. Endocrinology. 2006;147:4319–4329
  22. Richardson BD, Langland RA, Bachurski CJ, Richards RG, Kessler CA, Cheng YH, et al. Activator protein-2 regulates human placental lactogen gene expression. Mol Cell Endocrinol. 2000;160:183–192
  23. Richardson BD, Cheng YH, Langland RA, Handwerger S. Differential expression of AP-2gamma and AP-2alpha during human trophoblast differentiation. Life Sci. 2001;69:2157–2165
  24. Jin Y, Norquay LD, Yang X, Gregoire S, Cattini PA. Binding of AP-2 and ETS-domain family members is associated with enhancer activity in the hypersensitive site III region of the human growth hormone/chorionic somatomammotropin locus. Mol Endocrinol. 2004;18:574–587
  25. Cheng YH, Aronow BJ, Hossain S, Trapnell B, Kong S, Handwerger S. Critical role for transcription factor AP-2alpha in human trophoblast differentiation. Physiol Genomics. 2004;18:99–107
  26. Matt DW, Macdonald GJ. Placental steroid production by the basal and labyrinth zones during the latter third of gestation in the rat. Biol Reprod. 1985;32:969–977
  27. Ballester M, Castello A, Ibanez E, Sanchez A, Folch JM. Real-time quantitative PCR-based system for determining transgene copy number in transgenic animals. Biotechniques. 2004;37:610–613
  28. Brown RW, Chirala R. Utility of microwave-citrate antigen retrieval in diagnostic immunohistochemistry. Mod Pathol. 1995;8:515–520
  29. Nickel BE, Cattini PA. Nuclease sensitivity of the human growth hormone-chorionic somatomammotropin locus in pituitary and placenta suggest different mechanisms for tissue-specific regulation. Mol Cell Endocrinol. 1996;118:155–162
  30. Lytras A, Bock ME, Dodd JG, Cattini PA. Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase–polymerase chain reaction. Endocrinology. 1994;134:2461–2467
  31. Bennani-Baiti IM, Asa SL, Song D, Iratni R, Liebhaber SA, Cooke NE. DNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expression. Proc Natl Acad Sci U S A. 1998;95:10655–10660
  32. Ho Y, Elefant F, Cooke N, Liebhaber S. A defined locus control region determinant links chromatin domain acetylation with long-range gene activation. Mol Cell. 2002;9:291–302
  33. Ho Y, Elefant F, Liebhaber SA, Cooke NE. Locus control region transcription plays an active role in long-range gene activation. Mol Cell. 2006;23:365–375
  34. Ho Y, Tadevosyan A, Liebhaber SA, Cooke NE. The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression. EMBO Rep. 2008;9:891–898
  35. Cross JC, Baczyk D, Dobric N, Hemberger M, Hughes M, Simmons DG, et al. Genes, development and evolution of the placenta. Placenta. 2003;24:123–130
  36. Georgiades P, Ferguson-Smith AC, Burton GJ. Comparative developmental anatomy of the murine and human definitive placentae. Placenta. 2002;23:3–19
  37. Kamat A, Smith ME, Shelton JM, Richardson JA, Mendelson CR. Genomic regions that mediate placental cell-specific and developmental regulation of human Cyp19 (aromatase) gene expression in transgenic mice. Endocrinology. 2005;146:2481–2488
  38. Walker WH, Fitzpatrick SL, Saunders GF. Human placental lactogen transcriptional enhancer. Tissue specificity and binding with specific proteins. J Biol Chem. 1990;265:12940–12948
  39. Jacquemin P, Oury C, Peers B, Morin A, Belayew A, Martial JA. Characterization of a single strong tissue-specific enhancer downstream from the three human genes encoding placental lactogen. Mol Cell Biol. 1994;14:93–103
  40. Jiang SW, Eberhardt NL. The human chorionic somatomammotropin gene enhancer is composed of multiple DNA elements that are homologous to several SV40 enhansons. J Biol Chem. 1994;269:10384–10392
  41. Lytras A, Cattini PA. Human chorionic somatomammotropin gene enhancer activity is dependent on the blockade of a repressor mechanism. Mol Endocrinol. 1994;8:478–489
  42. Kimura AP, Liebhaber SA, Cooke NE. Epigenetic modifications at the human growth hormone locus predict distinct roles for histone acetylation and methylation in placental gene activation. Mol Endocrinol. 2004;18:1018–1032
  43. MacLeod JN, Lee AK, Liebhaber SA, Cooke NE. Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster. J Biol Chem. 1992;267:14219–14226
  44. Simmons DG, Rawn S, Davies A, Hughes M, Cross JC. Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus. BMC Genomics. 2008;9:352

PII: S0143-4004(08)00439-6

doi: 10.1016/j.placenta.2008.12.011

Placenta
Volume 30, Issue 3 , Pages 226-235 , March 2009

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