Placenta
Volume 30, Issue 5 , Pages 443-447 , May 2009

The H19 Gene Imprinting in Normal Pregnancy and Pre-eclampsia

  • L. Yu

      Affiliations

    • Department of Obstetrics and Gynecology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
  • ,
  • M. Chen

      Affiliations

    • Department of Laboratory Medicine, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
    • Co-first author.
  • ,
  • D. Zhao

      Affiliations

    • Department of Obstetrics and Gynecology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
  • ,
  • P. Yi

      Affiliations

    • Department of Obstetrics and Gynecology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
  • ,
  • L. Lu

      Affiliations

    • Department of Obstetrics and Gynecology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
  • ,
  • J. Han

      Affiliations

    • Department of Obstetrics and Gynecology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
  • ,
  • X. Zheng

      Affiliations

    • Department of Obstetrics and Gynecology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
  • ,
  • Y. Zhou

      Affiliations

    • Molecular Biology Center, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
  • ,
  • L. Li

      Affiliations

    • Department of Obstetrics and Gynecology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, PR China
    • Corresponding Author InformationCorresponding author. Department of Obstetrics and Gynecology, Daping Hospital, 10 Changjiang Zhilu, Chongqing 400042, PR China. Tel.: +86 23 68757926; fax: +86 23 68757602.

,Accepted 26 February 2009.

References 

  1. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365:785–799
  2. Lachmeijer AM, Dekker GA, Pals G, Aarnoudse JG, ten-Kate LP, Arngrimsson R. Searching for preeclampsia genes: the current position. Eur J Obstet Gynecol Reprod Biol. 2002;105:94–113
  3. Chelbi ST, Vaiman D. Genetic and epigenetic factors contribute to the onset of preeclampsia. Mol Cell Endocrinol. 2008;282:120–129
  4. Gabory A, Ripoche MA, Yoshimizu T, Dandolo L. The H19 gene: regulation and function of a non-coding RNA. Cytogenet Genome Res. 2006;113:188–193
  5. Hurst LD, Smith NG. Molecular evolutionary evidence that H19 RNA is functional. Trends Genet. 1999;15:134–135
  6. Rachmilewitz J, Gileadi O, Eldar-Geva T, Schneider T, de-Groot N, Hochberg A. Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta. Mol Reprod Dev. 1992;32:196–202
  7. Wake N, Arima T, Matsuda T. Involvement of IGF2 and H19 imprinting in choriocarcinoma development. Int J Gynecol Obstet. 1998;60:Sl–S8
  8. Fowden AL, Sibley C, Reik W, Constancia M. Imprinted genes, placental development and fetal growth. Horm Res. 2006;65:S50–S58
  9. Isles AR, Holland AJ. Imprinted genes and mother-offspring interactions. Early Hum Dev. 2005;81:73–77
  10. Isles AR, Wilkinson LS. Imprinted genes, cognition and behaviour. Trends Cogn Sci. 2000;4:309–318
  11. Davies W, Isles AR, Wilkinson LS. Imprinted genes and mental dysfunction. Ann Med. 2001;33:428–436
  12. Tycko B. Imprinted genes in placental growth and obstetric disorders. Cytogenet Genome Res. 2006;113:271–278
  13. Liou JM, Wu MS, Lin JW, Wang HP, Huang SP, Chiu HM, et al. Loss of imprinting of insulin-like growth factor II is associated with increased risk of proximal colon cancer. Eur J Cancer. 2007;43:1276–1282
  14. Guo L, Choufani S, Ferreira J, Smith A, Chitayat D, Shuman C, et al. Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae. Dev Biol. 2008;320:79–91
  15. Kim SJ, Park SE, Chan L, Lee SY, Kim IH, An HJ, et al. Altered imprinting, promoter usage, and expression of insulin-like growth factor-II gene in gestational trophoblastic diseases. Gynecol Oncol. 2003;88:411–418
  16. Visser M, Sijmons C, Bras J, Arceci RJ, Godfried M, Valentijn LJ, et al. Allelo type of pediatric rhabdomyosarcoma. Oncogene. 1997;15:1503–1510
  17. Bjornsson HT, Brown LJ, Fallin MD, Hans T, Rongione MA, Bibikova M, et al. Epigenetic specificity of loss of imprinting of the IGF2 gene in Wilms tumors. J Natl Cancer Inst. 2007;99:1270–1273
  18. Lucifero D, Chailler JR, Trasler JM. Potential significance of genomic imprinting defects for reproduction and assisted reproduction. Hum Reprod Update. 2004;10:3–18
  19. Pham NV, Nguyen MT, Hu JF, Hu JF, Vu TH, Hoffman AR. Dissociation of IGF2 and H19 imprinting in human brain. Brain Res. 1998;810:1–8
  20. Walsh C, Miller SJ, Flam F, Fisher RA, Ohlsson R. Paternally derived H19 is differentially expressed in malignant and nonmalignant trophoblast. Cancer Res. 1995;55:1111–1119
  21. Ariel I, Lustig O, Oyer CE, Elkin M, Gonik B, Rachmilewitz J, et al. Relaxation of imprinting in trophoblastic disease. Gynecol Oncol. 1994;53:212–219
  22. Jinno Y, Ikeda Y, Yun K, Maw M, Masuzaki H, Fukuda H, et al. Establishment of functional imprinting of H19 gene in human developing placentae. Nat Genet. 1995;10:318–324
  23. Arima T, Matsuda T, Takagi N. Association of IGF2 and H19 imprinting with choriocarcinoma development. Cancer Genet Cytogenet. 1997;93:39–47
  24. Aparecida RC, Pontes A, Rogatto SR. Expression and imprinting of insulin-like growth factor II (IGF2) and H19 genes in uterine leiomyomas. Gynecol Oncol. 1999;74:375–380
  25. Kim SJ, Park SE, Chan L, Lee SY, Jo JH, Kim JM, et al. Alterations in promoter usage and expression levels of insulin-like growth factor-II and H19 genes in cervical carcinoma exhibiting biallelic expression of IGF-II. Biochim Biophys Acta. 2002;1586:307–315
  26. Merviel P, Carbillion L, Challier JC, Rabreau M, Beaufils M, Uzan S. Pathophysiology of preeclampsia: links with implantation disorders. Eur J Obstet Gynecol Reprod Biol. 2004;115:134–147
  27. Ayesh S, Matouk I, Schneider T, Ohana P, Laster M, Al-Sharef W, et al. Possible physiological role of H19 RNA. Mol Carcinog. 2002;35:63–74
  28. Egbor M, Ansari T, Morris N, Green CJ, Sibbons PD. Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction. BJOG. 2006;113:580–589
  29. Hark AT, Schoenherr CJ, Katz DJ, Ingram RS, Levorse JM, Tilghman SM. CTCF mediates methylation-sensitive enhancer-blocking activity at H19/Igf2 locus. Nature. 2000;405:486–489
  30. Constancia M, Kelsey G, Reik W. Resourceful imprinting. Nature. 2004;432:53–57
  31. Jennifer A, Marshall G. Genomic imprinting, development and disease-is pre-eclampsia caused by a maternally imprinted gene?. Reprod Fertil Dev. 1998;10:23–29
  32. Mutter WP, Karumanchi SA. Molecular mechanisms of preeclampsia. Microvasc Res. 2008;75:1–8
  33. Zhou Y, Fisher SJ, Janatpour M, Genbacev O, Dejana E, Wheelock M, et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate: a strategy for successful endovascular invasion?. J Clin Invest. 1997;99:2139–2151
  34. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science. 2005;308:1592–1594
  35. Smets EML, Visser A, Go ATJI, van Vugt JMG, Oudejans CBM. Novel biomarkers in preeclampsia. Clin Chim Acta. 2006;364:22–32

PII: S0143-4004(09)00078-2

doi: 10.1016/j.placenta.2009.02.011

Placenta
Volume 30, Issue 5 , Pages 443-447 , May 2009