Placenta
Volume 30, Issue 6 , Pages 536-538 , June 2009

Inhibitors of Heme Oxygenase Reduce Invasion of Human Primary Cytotrophoblast Cells In vitro

,Accepted 9 March 2009.

References 

  1. Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms and clinical applications. FASEB J. 1988;2:2557–2568
  2. McFaul SJ, McGrath JJ. Studies on the mechanism of carbon monoxide-induced vasodilatation in the isolated perfused rat heart. Toxicol Appl Pharmacol. 1987;87:464–473
  3. Keyse SM, Tyrell RM. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide and sodium arsenite. Proc Natl Acad Sci U S A. 1989;86:99–103
  4. Maines MD, Mayer RD, Ewing JF, McCoubrey WKJ. Induction of kidney heme oxygnease-1 (HSP32) mRNA and protein by ischemia/reperfusion: possible role of heme as both promoter of tissue damage and regulator of HSP32. J Pharmacol Exp Ther. 1993;264:457–462
  5. Shibahara S, Müller RM, Taguchi H. Transcriptional control of rat heme oxygenase by heat shock. J Biol Chem. 1987;262:12889–12892
  6. McCoubrey WKJ, Huang JT, Maines MD. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem. 1997;247:725–732
  7. Lyall F, Barber A, Myatt L, Bulmer JN, Robson SC. Hemeoxygenase expression in human placenta and placental bed implies a role in regulation of trophoblast invasion and placental function. FASEB J. 2000;14:208–219
  8. Barber A, Robson SC, Myatt L, Bulmer JN, Lyall F. Hemeoxygenase expression in human placenta and placental bed: reduced expression of placenta endothelial HO-2 in preeclampsia and fetal growth restriction. FASEB J. 2001;15:1158–1168
  9. Newby D, Cousins F, Myatt L, Lyall F. Heme oxygenase expression in cultured human trophoblast cells during in vitro differentiation: Effects of hypoxia. Placenta. 2005;26:201–209
  10. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JM. Purification, characterization and in vitro differentiation of cytotrophoblast from human term placenta. Endocrinology. 1986;118:1567–1582
  11. Ryter SW, Alam J, Choi AMK. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006;86:583–50
  12. Dulak J, Deshane J, Jozkowicz A, Agarwal A. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation. 2008;117:231–241
  13. Kim HP, Wang X, Galbiati F, Ryter SW, Choi AMK. Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J. 2004;18:1080–1089
  14. Linton EA, Rodriguez-Linares B, Rashid-Doubell F, Ferguson DJ, Redman CW. Caveolae and caveolin-1 in human term villous trophoblast. Placenta. 2003;24:745–757
  15. Oh P, Borgström P, Witkiewicz H, Li Y, Borgström BJ, Chrastina A, et al. Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotech. 2007;25:327–337
  16. McCaig D, Lyall F. Heme oxygenase expression in human placental villous tissue in response to exposure to in vitro ischaemia-reperfusion injury. Hypertens Preg in press.
  17. Bilban IM, Haslinger P, Prast J, Klinglmüller F, Woelfel T, Haider S, et al. Identification of novel trophoblast invasion-related genes: Heme oxygenase-1 controls motility via PPAR. Endocrinology. 2009;17:1000–1013

PII: S0143-4004(09)00089-7

doi: 10.1016/j.placenta.2009.03.004

Placenta
Volume 30, Issue 6 , Pages 536-538 , June 2009

Article Tools

* Image Usage & Resolution