Placenta
Volume 30, Issue 6 , Pages 491-496 , June 2009

Intraperitoneal Administration of Shiga Toxin Type 2 in Rats in the Late Stage of Pregnancy Produces Premature Delivery of Dead Fetuses

  • J. Burdet

      Affiliations

    • Laboratorio de Fisiopatogenia, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    • ,
  • E. Zotta

      Affiliations

    • Laboratorio de Fisiopatogenia, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    • ,
  • A.M. Franchi

      Affiliations

    • CEFYBO-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
    • ,
  • C. Ibarra

      Affiliations

    • Laboratorio de Fisiopatogenia, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    • Corresponding Author InformationCorresponding author. Depto de Fisiología, Facultad de Medicina, Paraguay 2155, 7° piso, CP 1121, Buenos Aires, Argentina. Tel.: +54 11 59509500.

,Accepted 21 March 2009.

References 

  1. Griffin PM, Tauxe RV. The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli, and the associated hemolytic uremic síndrome. Epidemiol Rev. 1991;13:60–98
  2. Hussein HS, Bollinger LM. Prevalence of Shiga toxin-producing Escherichia coli in beef cattle. J Food Prot. 2005;68:2224–2241
  3. Rivas M, Miliwebsky E, Chinen I, Deza N, Leotta G. The epidemiology of hemolytic uremic syndrome in Argentina. Diagnosis of the etiologic agent, reservoirs and routes of transmission. Medicina (B Aires). 2006;66:27–32
  4. Lindgwood CA. Role of verotoxin receptors in patogénesis. Trends Microbiol. 1996;4:147–153
  5. Taga S, Carlier K, Mishal Z, Capoulade C, Mangeney M, Lecluse Y, et al. Intracellular signaling events in CD77-mediated apoptosis of Burkitt's lymphoma cells. Blood. 1997;90:2757–2767
  6. Pistone Creydt V, Silberstein C, Zotta E, Ibarra C. Cytotoxic effect of Shiga toxin-2 holotoxin and its B subunit on human renal tubular epithelial cells. Microbes Infect. 2006;8:410–419
  7. Silberstein C, Pistone Creydt V, Gerhardt E, Núñez P, Ibarra C. Inhibition of water absorption in human proximal tubular epithelial cells in response to Shiga toxin-2. Pediatr Nephrol. 2008;23:1981–1990
  8. Creydt VP, Miyakawa MF, Martin F, Zotta E, Silberstein C, Ibarra C. The Shiga toxin 2 B subunit inhibits net fluid absorption in human colon and elicits fluid accumulation in rat colon loops. Braz J Med Biol Res. 2004;37:799–808
  9. Tesh VL, Ramegowda B, Samuel JE. Purified Shiga-like toxins induce expression of proinflammatory cytokines from murine peritoneal macrophages. Infect Immun. 1994;62:5085–5094
  10. Louise CB, Obrig TG. Shiga toxin-associated hemolytic-uremic syndrome: combined cytotoxic effects of Shiga toxin, interleukin-1 beta, and tumor necrosis factor alpha on human vascular endotelial cells in vitro. Infect Immun. 1991;59:4173–4179
  11. Louise CB, Obrig TG. Shiga toxin-associated hemolytic uremic syndrome: combined cytotoxic effects of Shiga toxin and lipopolysaccharide (endotoxin) on human vascular endothelial cells in vitro. Infect Immun. 1992;60:1536–1543
  12. Chart H, Perry NT, Cheasty T, Wright PA. The kinetics of antibody production to antigens of Escherichia coli O157 in a pregnant woman with haemolytic uraemic síndrome. J Med Microbiol. 2002;51:522–525
  13. Adachi E, Tanaka H, Toyoda N, Takeda T. Detection of bactericidal antibody in the breast milk of a mother infected with enterohemorrhagic Escherichia coli O157:H7. Kansenshogaku Zasshi. 1999;73:451–456
  14. Lamont RF, Sawant SR. Infection in the prediction and antibiotics in the prevention of spontaneous preterm labour and preterm birth. Minerva Ginecol. 2005;57:423–433
  15. Goldstein J, Loidl CF, Pistone Creydt V, Boccoli J, Ibarra C. Intracerebroventricular administration of Shiga toxin type 2 induces striatal neuronal death and glial alterations: An ultrastructural study. Brain Res. 2007;1161:106–115
  16. Yoshimura K, Tanimoto A, Abe T, Ogawa M, Yutsudo T, Kashimura M, et al. Shiga toxin 1 and 2 induce apoptosis in the amniotic cell lie WISH. J Soc Gynecol Investig. 2002;9:22–26
  17. Yoshimura K, Fujii J, Tanimoto A, Yutsudo T, Kashimura M, Yoshida S. Effects of Shiga toxin 2 on lethality, fetuses, delivery, and puerperanl behavior in pregnant mice. Infect Immun. 2000;68:2254–2258
  18. Sargison ND, Howie F, Thomson JR, Dun K, Penny CD. Ovine placentitis and aborption associated with a verotoxigenic strain of Escherichia coli. Vet Rec. 2001;149:711–712
  19. Sargison ND, Howie F, Mearns R, Penny CD, Foster G. Shiga toxin-producing Escherichia coli as a perennial cause of aborption in a closed flock of Suffolk ewes. Vet Rec. 2007;160:875–876
  20. Whipp SC, Rasmussen MA, Cray WC. Animals as a source of Escherichia coli pathogens for human beings. J Am Vet Med Assoc. 1994;204:1168–1175
  21. Beutin L, Knollmann-Schanbacher G, Rietschel W, Sefger H. Animal reservoirs of Escherichia coli O157:H7. Vet Rec. 1996;139:70–71
  22. Louise C, Obrig T. Shiga toxin-associated hemolytic uremic syndrome: combined cytotoxic effects of Shiga toxin and lipopolysaccharide (endotoxin) on human vascular endotelial cells in vitro. Infect Immun. 1992;60:1536–1543
  23. Zhang H, Peterson JW, Niesel DW, Klimpel GR. Bacterial lipoprotein and lipopolysaccharide act synergistically to induce letal shock and proinflammatoy cytokine production. J Immunol. 1997;159:4868–4878
  24. Gordiani N, Sutor AH, Zimmerhacki LB, Brandis M. Hemolytic uremic syndrome in childhood. Semin Thromb Hemost. 1997;23:281–293
  25. Noris M, Ruggenenti P, Todeschini M, Figliuzzi M, Macconi D, Zoja C, et al. Increased nitric oxide formation in recurrent thrombotic microangiopathies: a possible mediator of microvascular injury. Am J Kidney Dis. 1996;27:790–796
  26. Ogando DG, Paz D, Cella M, Franchi AM. The fundamental role of increased production of nitric oxide in lipopolysaccharide-induced embryonic resorption in mice. Reproduction. 2003;125:95–110
  27. Aisemberg J, Vercelli C, Billi S, Ribeiro ML, Ogando D, Meiss R, et al. Nitric oxide mediates prostaglandins' deleterious effect on lipopolysaccharide-triggered murine fetal resorption. Proc Natl Acad Sci USA. 2007;104:7534–7539
  28. Swaisgood CM, Zu H-X, Perkins DJ, Wu S, Garver CL, Zimmerman PD, et al. Coordinate expression of inducible nitric oxide synthase and cyclooxygenase-2 genes in uterine tissues of endotoxin-treated pregnant mice. Am J Obstet Gynecol. 1997;177:1253–1262
  29. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys. 1991;288:481–487
  30. Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin J, Smith C, et al. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys. 1992;298:431–437
  31. Radi R, Rodriguez M, Castro L, Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys. 1994;308:89–95

PII: S0143-4004(09)00096-4

doi: 10.1016/j.placenta.2009.03.012

Placenta
Volume 30, Issue 6 , Pages 491-496 , June 2009

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