Placenta
Volume 30, Issue 6 , Pages 529-535 , June 2009

Responses of Isolated Pressurised Rat Uterine Arteries to Changes in Pressure: Effects of Pre-constriction, Endothelium and Pregnancy

  • S.B. Withers

      Affiliations

    • Cardiovascular Research Group, School of Clinical and Laboratory Sciences, Core Technology Facility, 46 Grafton Street, University of Manchester, Manchester M13 9NT, UK
    • ,
  • M.J. Taggart

      Affiliations

    • Institute of Cellular Medicine, Newcastle University, UK
    • ,
  • P. Baker

      Affiliations

    • Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, St. Mary's Hospital, University of Manchester, UK
    • ,
  • C. Austin

      Affiliations

    • Cardiovascular Research Group, School of Clinical and Laboratory Sciences, Core Technology Facility, 46 Grafton Street, University of Manchester, Manchester M13 9NT, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 161 275 1214; fax: +44 161 275 1183.

,Accepted 22 March 2009.

References 

  1. Ueland K, Novy MJ. Peterson EN maternal cardiovascular dynamics. IV. The influence of gestational cardiovascular responses to posture and exercise. Am J Obstet Gynecol. 1969;104:856
  2. Robson SC, Hunter S, Boys RJ, Dunlop W. Serial study of factors influencing changes in cardiac output during human pregnancy. Am J Physiol. 1989;256:H1060–H1065
  3. Gokina NI, Mandala M, Osol G. Induction of localized differences in rat uterine radial artery behaviours and structure during gestation. Am J Obstet Gynecol. 2003;189:1489–1493
  4. Makikallio K, Tekay A, Jouppila P. Uteroplacental hemodynamics during early human pregnancy: a longitudinal study. Gynecol Obstet Invest. 2004;58:49–54
  5. Harrington K, Cooper D, Lees K, Hecher K, Campbell S. Doppler ultrasound of the uterine arteries: the importance of bilateral notching in the prediction of pre eclampsia, placental abruption or delivery of a small for gestational age baby. Ultrasound Obstet Gynecol. 1996;7:182–188
  6. Lang U, Scott Baker R, Braems G, Zygmunt M, Kunzel W, Clark KE. Uterine blood flow – a determinant of fetal growth. Eur J Obstet Gynecol Reprod Biol. 2003;110(Suppl. 1):S55–S61
  7. Schubert R, Mulvany MJ. The myogenic response: established facts and attractive hypotheses. Clin Sci. 1999;96:313–326
  8. Osol G, Brekke JF, McElroy-Yaggy K, Gokina NI. Myogenic tone, reactivity and forced dilatation: a three-phase model of in vitro arterial myogenic behaviour. Am J Physiol. 2002;283:H2260–H2267
  9. Cipolla MJ, Binder ND, Osol G. Myoendometrial versus placental uterine arteries: structural, mechanical and functional differences in late-pregnant rabbits. Am J Obstet Gynecol. 1997;177:215–221
  10. Osol G, Cipolla M. Interaction of myogenic and adrenergic mechanisms in isolated, pressurized uterine radial arteries from late-pregnant and nonpregnant rats. Am J Obstet Gynecol. 1993;168:697–705
  11. Telezhkin V, Goecks T, Bonev AD, Osol G, Gokina NI. Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy. Am J Physiol. 2008;294:H272–H284
  12. Veerareddy S, Cooke C-LM, Baker PN, Davidge ST. Vascular adaptations to pregnancy in mice: effects on myogenic tone. Am J Physiol. 2002;283:H2226–H2233
  13. Xiao D, Buchholz JN, Zhang L. Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway. Am J Physiol;290:H2337–43.
  14. Schubert R, Lidington D, Bolz SS. The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc Res. 2008;77:8–18
  15. Meininger GA, Faber JE. Adrenergic facilitation of myogenic response in skeletal muscle arterioles. Am J Physiol. 1991;260:H1424–H1432
  16. Zhang H, Xiao D, Longo LD, Zhang L. Regulation of alpha1-adrenoceptor-mediated contractions of uterine arteries by PKC: effect of pregnancy. Am J Physiol. 2006;291:H2282–H2289
  17. Doughty JM, Langton PD. A transient dilatation of pressurised rat cerebral arteries during rapid pressure increase is mediated by nitric oxide. Pflugers Arch. 1998;436:220–226
  18. Hafez ESE. Reproduction and breeding techniques for laboratory animals. Philadelphia: Lea and Febiger; 1970;p. 115–7
  19. Shaw L, Taggart M, Austin C. Effects of the oestrous cycle and gender on acute vasodilatory responses of isolated pressurized rat mesenteric arteries to 17 beta-oestradiol. Br J Pharmacol. 2001;132:1055–1062
  20. Nemenoff RA. Vasopressin signalling pathways in vascular smooth muscle. Front Biosci. 1998;3:d194–207
  21. Veerareddy S, Campbell ME, Williams SJ, Baker PN, Davidge S. Myogenic reactivity is enhanced in rat radial uterine arteries in a model of maternal undernutrition. Am J Obstet Gynecol. 2004;191:334–349
  22. Jarajapu YP, Knot HJ. Role of phospholipase C in development of myogenic tone in rat posterior cerebral arteries. Am J Physiol. 2003;283:H2234–H2238
  23. Bird IM, Zhang L, Magness RR. Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function. Am J Physiol. 2003;284:R245–R258

PII: S0143-4004(09)00097-6

doi: 10.1016/j.placenta.2009.03.011

Placenta
Volume 30, Issue 6 , Pages 529-535 , June 2009

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