Placenta
Volume 30, Issue 7 , Pages 649-653 , July 2009

Expression of Pleiotrophin and its Receptors in Human Placenta Suggests Roles in Trophoblast Life Cycle and Angiogenesis

  • M. Ball

      Affiliations

    • Department of Biochemistry, Biosciences Institute, University College Cork, College Road, Cork, Ireland
    • ,
  • M. Carmody

      Affiliations

    • Department of Biochemistry, Biosciences Institute, University College Cork, College Road, Cork, Ireland
    • ,
  • F. Wynne

      Affiliations

    • Department of Biochemistry, Biosciences Institute, University College Cork, College Road, Cork, Ireland
    • ,
  • P. Dockery

      Affiliations

    • Department of Anatomy, National University of Ireland Galway, Galway, Ireland
    • ,
  • A. Aigner

      Affiliations

    • Department of Pharmacology and Toxicology, Philipps-University Marburg, Marburg, Germany
    • ,
  • I. Cameron

      Affiliations

    • Developmental Origins of Health and Disease Division, University of Southampton, Princess Anne Hospital, Southampton, UK
    • ,
  • J. Higgins

      Affiliations

    • Anu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Cork, Ireland
    • ,
  • S.D. Smith

      Affiliations

    • Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    • ,
  • J.D. Aplin

      Affiliations

    • Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 (0)161 276 6487; fax: +44 (0)161 276 6134.
    • ,
  • T. Moore

      Affiliations

    • Department of Biochemistry, Biosciences Institute, University College Cork, College Road, Cork, Ireland
    • Corresponding Author InformationCorresponding author. Tel.: +353 (0)21 490 1339; fax: +353 (0)21 490 1382.

,Accepted 1 May 2009.

References 

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  2. Maeda N, Nishiwaki T, Shintani T, Hamanaka H, Noda M. 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM). J Biol Chem. 1996;271(35):21446–21452
  3. Kinnunen T, Raulo E, Nolo R, Maccarana M, Lindahl U, Rauvala H. Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface. J Biol Chem. 1996;271(4):2243–2248
  4. Deepa SS, Yamada S, Zako M, Goldberger O, Sugahara K. Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor. J Biol Chem. 2004;279(36):37368–37376
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  8. Schulte AM, Wellstein A. Structure and phylogenetic analysis of an endogenous retrovirus inserted into the human growth factor gene pleiotrophin. J Virol. 1998;72(7):6065–6072
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  12. Anjum N, Baker PN, Robinson NJ, Aplin JD. Maternal celiac disease autoantibodies bind directly to syncytiotrophoblast and inhibit placental tissue transglutaminase activity. Reprod Biol Endocrinol. 2009;7:16
  13. Bowden ET, Stoica GE, Wellstein A. Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase. J Biol Chem. 2002;277(39):35862–35868
  14. Li J, Wei H, Chesley A, Moon C, Krawczyk M, Volkova M, et al. The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity. J Biol Chem. 2007;282(48):34984–34993
  15. Jokimaa VI, Kujari HP, Ekholm EM, Inki PL, Anttila L. Placental expression of syndecan 1 is diminished in preeclampsia. Am J Obstet Gynecol. 2000;183(6):1495–1498
  16. Norris K, Norris F, Kono DH, Vestergaard H, Pedersen O, Theofilopoulos AN, et al. Expression of protein-tyrosine phosphatases in the major insulin target tissues. FEBS Lett. 1997;415(3):243–248
  17. Perez-Pinera P, Chang Y, Deuel TF. Pleiotrophin, a multifunctional tumor promoter through induction of tumor angiogenesis, remodeling of the tumor microenvironment, and activation of stromal fibroblasts. Cell Cycle. 2007;6(23):2877–2883
  18. Perez-Pinera P, Zhang W, Chang Y, Vega JA, Deuel TF. Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signalling pathway: an alternative mechanism of receptor tyrosine kinase activation. J Biol Chem. 2007;282(39):28683–28690
  19. Antoine M, Tag CG, Wirz W, Borkham-Kamphorst E, Sawitza I, Gressner AM, et al. Upregulation of pleiotrophin expression in rat hepatic stellate cells by PDGF and hypoxia: implications for its role in experimental biliary liver fibrogenesis. Biochem Biophys Res Commun. 2005;337(4):1153–1164
  20. Herradon G, Ezquerra L, Nguyen T, Vogt TF, Bronson R, Silos-Santiago I, et al. Pleiotrophin is an important regulator of the renin–angiotensin system in mouse aorta. Biochem Biophys Res Commun. 2004;324(3):1041–1047
  21. Ezquerra L, Herradón G, Nguyen T, Vogt TF, Bronson R, Silos-Santiago I, et al. Pleiotrophin is a major regulator of the catecholamine biosynthesis pathway in mouse aorta. Biochem Biophys Res Commun. 2004;323(2):512–517
  22. Kokolakis G, Mikelis C, Papadimitriou E, Courty J, Karetsou E, Katsoris P. Effect of heparin affin regulatory peptide on the expression of vascular endothelial growth factor receptors in endothelial cells. Vivo. 2006;20(5):629–635
  23. Sharifi BG, Zeng Z, Wang L, Song L, Chen H, Qin M, et al. Pleiotrophin induces transdifferentiation of monocytes into functional endothelial cells. Arterioscler Thromb Vasc Biol. 2006;26(6):1273–1280
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  27. Zhang N, Zhong R, Perez-Pinera P, Herradon G, Ezquerra L, Wang ZY, et al. Identification of the angiogenesis signaling domain in pleiotrophin defines a mechanism of the angiogenic switch. Biochem Biophys Res Commun. 2006;343(2):653–658

PII: S0143-4004(09)00147-7

doi: 10.1016/j.placenta.2009.05.001

Placenta
Volume 30, Issue 7 , Pages 649-653 , July 2009

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