Placenta
Volume 30, Issue 10 , Pages 884-890 , October 2009

Azithromycin Inhibits Vertical Transmission of Toxoplasma gondii in Calomys callosus (Rodentia: Cricetidae)

  • I.N. Costa

      Affiliations

    • Laboratory of Histology and Embriology, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Bloco 2B, Uberlândia 38405-320, MG, Brazil
  • ,
  • M.B. Angeloni

      Affiliations

    • Laboratory of Histology and Embriology, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Bloco 2B, Uberlândia 38405-320, MG, Brazil
  • ,
  • L.A. Santana

      Affiliations

    • Laboratory of Histology and Embriology, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Bloco 2B, Uberlândia 38405-320, MG, Brazil
  • ,
  • B.F. Barbosa

      Affiliations

    • Laboratory of Histology and Embriology, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Bloco 2B, Uberlândia 38405-320, MG, Brazil
  • ,
  • M.C.P. Silva

      Affiliations

    • Laboratory of Histology and Embriology, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Bloco 2B, Uberlândia 38405-320, MG, Brazil
  • ,
  • A.A. Rodrigues

      Affiliations

    • Laboratory of Histology and Embriology, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Bloco 2B, Uberlândia 38405-320, MG, Brazil
  • ,
  • C. Rostkowsa

      Affiliations

    • Laboratory of Immunoparasitology, Universidade Federal de Uberlândia, Av. Pará, 1720, Bloco 4C, Uberlândia 38405-320, MG, Brazil
  • ,
  • P.M. Magalhães

      Affiliations

    • Laboratory of Agrotechnology, Universidade Estadual de Campinas, Rua Alexandre Cazelatto, 999, Vila Betel, Campinas 13081-970, SP, Brazil
  • ,
  • J.D.O. Pena

      Affiliations

    • Laboratory of Immunoparasitology, Universidade Federal de Uberlândia, Av. Pará, 1720, Bloco 4C, Uberlândia 38405-320, MG, Brazil
  • ,
  • D.A.O. Silva

      Affiliations

    • Laboratory of Immunoparasitology, Universidade Federal de Uberlândia, Av. Pará, 1720, Bloco 4C, Uberlândia 38405-320, MG, Brazil
  • ,
  • J.R. Mineo

      Affiliations

    • Laboratory of Immunoparasitology, Universidade Federal de Uberlândia, Av. Pará, 1720, Bloco 4C, Uberlândia 38405-320, MG, Brazil
  • ,
  • E.A.V. Ferro

      Affiliations

    • Laboratory of Histology and Embriology, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Bloco 2B, Uberlândia 38405-320, MG, Brazil
    • Corresponding Author InformationCorresponding author. Tel./fax: +55 34 3218 2240.

,Accepted 4 August 2009.

References 

  1. Mozzatto L, Procianoy RS. Incidence of congenital toxoplasmosis in Southern Brazil: a prospective study. Rev Inst Med Trop São Paulo. 2003;45:147–151
  2. Luft BJ, Brooks RG, Conley FK. Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome. J Am Med Assoc. 1984;252:913–917
  3. Dantas-Leite L, Urbina JA, Souza W, Vommaro RC. Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii. Int J Antimicrob Agents. 2005;25:130–135
  4. Elsheikha HM. Congenital toxoplasmosis: priorities for further health promotion action. J R Inst Public Health. 2008;122:335–353
  5. Sonda S, Hehl A. Lipid biology of Apicomplexa: perspetives for new drug targets, particularly for Toxoplasma gondii. Trends Parasitol. 2006;22:41–47
  6. Degerli K, Kilimcioglu AA, Kurt O, Tamay AT, Ozbilgin A. Efficacy of azitromycin in a murine toxoplasmosis model, employing a Toxoplasma gondii strain from Turkey. Acta Trop. 2003;88:45–50
  7. Daffos F, Forestier F, Capella-Pavlovsky M, Thulliez P, Aufrant C, Valenti D, et al. Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis. N Engl J Med. 1998;318:271–275
  8. Anderson AC. Targeting DHFR in parasitic protozoa. Drug Discov Today. 2005;10:121–128
  9. Gobel A, McArdell CS, Joss A, Siegrist H, Giger W. Fate of sulfonamides, macrolides, and trimethroprim in different wastewater treatment technologies. Sci Total Environ. 2007;372:361–371
  10. Schmidt DR, Hogh B, Andersen O, Hansen ST, Dalhoff K, Petersen E. Treatment of infants with congenital toxoplasmosis: tolerability plasma concentrations of sulphadiazine and pyrimethamine. Eur J Pediatr. 2006;165:19–25
  11. Lavine MD, Arrizabalaga G. Invasion and egress by the obligate intracellular parasite Toxoplasma gondii: potential targets for the development of new antiparasitic drugs. Curr Pharm Des. 2007;13:641–651
  12. Grujié J, Djurkovié-djakovic O, Nikolié A, Klun I, Bobié B. Effectiveness of spiramycin in murine models of acute and chronic toxoplasmosis. Int J Antimicrob Agents. 2004;25:226–230
  13. Ou-Yang k, Krug EC, Marr JJ, Berens RL. Inhibition of growth of Toxoplasma gondii by Qinghaosu and derivates. Antimicrobial Agents Chemother. 1990;3:1961–1965
  14. Ridder S, Van der Kooy F, Verpoorte R. Artemisia annua as a self-reliant treatment for malaria in developing countries. J Ethnopharmacol. 2008;120:302–314
  15. Oliveira TC, Silva DAO, Rostkowska C, Béla SR, Ferro EAV, Magalhães PM, et al. Toxoplasma gondii: effects of Artemisia annua L. on susceptibility to infection in experimental models in vitro and in vivo. Exp Parasitol. 2009;122:233–241
  16. Hu K, Johnson J, Florens L, Fraunholz M, Suravajjala S, Dilullo C, et al. Cytoskeletal components of an invasion machine the apical complex of Toxoplasma gondii. PLoS Pathog. 2006;2:13
  17. Sarciron ME, Saccharin C, Petavy AF, Peyron F. Effects of artesunate, dihydroartemisinin and an artesunate-dihydroartemisin combination against Toxoplasma gondii. Am Soc Trop Med Hyg. 2000;62:73–76
  18. Ferro EAV, Silva DAO, Bevilacqua E, Mineo JR. Effect of Toxoplasma gondii infection kinetics on trophoblast cell population in Calomys callosus, a model of congenital toxoplasmosis. Infect Immun. 2002;70:7089–7094
  19. Oliveira JG, Silva NM, Santos AAD, Souza MA, Ferreira GLS, Mineo JR, et al. BeWo trophoblasts are unable to control replication of Toxoplasma gondii, even in the presence of exogeous IFN-γ. Placenta. 2006;27:691–698
  20. Barbosa BF, Silva DAO, Costa IN, Pena JD, Mineo JR, Ferro EAV. Susceptibility to vertical trasmission of Toxoplasma gondii is temporally dependent on the preconceptional infection in Calomys callosus. Placenta. 2007;28:624–630
  21. Duarte MCT, Figueira GM, Pereira B, Magalhães PM, Delarmelina C. Atividade antimicrobiana de extratos hidroalcoólicos de espécies da coleção de plantas medicinais CPQBA/UNICAMP. Plantas. 2005;14:11–33
  22. Rath K, Táxis K, Walz G, Gleiter CH, Li SM, Heid L. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (Annuam wormwood). Am J Trop Med Hyg. 2004;7:128–132
  23. Remington JS, Mcleod R, Thulliez P, Desmonts G. Toxoplasmosis. In:  Remington JS,  Klein OJ editor. Infectious diseases of the fetus and newborn infant. 5th ed.. Philadelphia: Saunders; 2001;p. 205–356
  24. Freyre A, Falcòn J, Rodriguez A, Correa L, Gonzalez M. Toxoplasma gondii: partial cross-protection among several strains of the parasite against congenital transmission in a rat model. Exp Parasitol. 2006;112:8–12
  25. Ferguson DJP. Use of molecular and ultrastructural markers to evaluate stage conversion of Toxoplasma gondii in both the intermediate and definitive host. Int J Parasitol. 2004;34:347–360
  26. Silva NM, Rodrigues CV, Santoro MM, Reis LFL, Alvarez-Leite JL, Gazzinelli RT. Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor1. Infect Immun. 2002;70:859–868
  27. Wilson MB, Nakame PK. Antibody conjugated to horseradish peroxidase. In:  Knapp W,  Holubar K,  Wick G editor. Immunofluorescence and related staining technique. Amsterdam: Elsevier North Holland Biomedical; 1978;p. 215–224
  28. Dellicour S, Hall S, Chandramohan D, Greenwood B. The safety of artemisinins during pregnancy: a pressing question. Malar J. 2007;6–15
  29. Clark RL, White TE, Clodes A, Gaunt SI, Winstanley P, Ward SA. Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit. Birth Defects Res B Dev Reprod Toxicol. 2004;71:380–394
  30. Boareto AC, Muller JC, Bufalo AC, Botelho GGK, Araujo SL, Foglio MA, et al. Toxicity of artemisinin (Artemisia annua L.) in two different periods of pregnancy in Wistar rats. Reprod Toxicol. 2008;25:239–246
  31. Longo M, Zanoncelli S, Torre PD, Rosa F, Giusti A, Colombo P, et al. Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX). Reprod Toxicol. 2008;25:433–441
  32. Favoreto-junior S, Ferro EAV, Clemente D, Silva DAO, Mineo JR. Experimental infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii. Mem Inst Oswaldo Cruz. 1998;93:103–107
  33. Sullivan WJ, Hakimi M. Histone mediated gene activation in Toxoplasma gondii. Mol Biochem Parasitol. 2006;148:109–116
  34. Dubey JP. Toxoplasmosis – a waterborne zoonosis. Vet Parasitol. 2004;126:52–72
  35. Lopes CD, Silva NM, Ferro EA, Sousa RA, Firmino ML, Bernardes ES, et al. Azithromycin reduces ocular infection during congenital transmission of toxoplasmosis in the Calomys Callosus model. J Parasitol. 2009;95:1–9
  36. Gagne SS. Toxoplasmosis. Prim Care Update Ob Gyns. 2001;3:122–126
  37. Todros T, Verdiglione P, Oggè G, Paladini D, Vergani P, Cardaropoli S. Low incidence of hypertensive disorders of pregnancy in women treated with spiramycin for Toxoplasma infection. Br J Clin Pharmacol. 2006;61:336–340
  38. Katzung BC. Toxoplasma gondii. In: Farmacologia Básica & Clínica. 9th ed.. Rio de Janeiro: Guanabara Koogan; 2006;p. 546–554
  39. Gratzl R, Sodeck G, Platzer P, Jager W, Graf J, Pollak A, et al. Treatment of toxoplasmosis in pregnancy: concentrations of spiramycin and neospiramycin in maternal serum and amniotic fluid. Eur J Clin Microbiol Infect Dis. 2002;21:12–16
  40. Beckers CJ, Ross DS, Donald RG, Luft BJ, Schwab JC, Cao Y, et al. Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics. J Clin Invest. 1995;95:367–376

PII: S0143-4004(09)00256-2

doi: 10.1016/j.placenta.2009.08.002

Placenta
Volume 30, Issue 10 , Pages 884-890 , October 2009