Placenta
Volume 31, Issue 1 , Pages 18-24 , January 2010

Decreased adherence and spontaneous separation of fetal membrane layers – amnion and choriodecidua – a possible part of the normal weakening process

  • A. Strohl

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • D. Kumar

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • R. Novince

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • P. Shaniuk

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • J. Smith

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • K. Bryant

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • R.M. Moore

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • J. Novak

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • B. Stetzer

      Affiliations

    • Reproductive Biology, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • B.M. Mercer

      Affiliations

    • Reproductive Biology, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • ,
  • J.M. Mansour

      Affiliations

    • Mechanical and Aerospace Engineering, Case Western Reserve University (CWRU), 10900 Euclid Avenue, Cleveland, OH, USA
    • ,
  • J.J. Moore

      Affiliations

    • Departments of Pediatrics, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • Reproductive Biology, Case Western Reserve University (CWRU), MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, USA
    • Corresponding Author InformationCorresponding author and reprint requests: John J. Moore, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA. Tel.: +1 216 778 5909(W); fax: +1 216 778 3252.

,Accepted 27 October 2009.

References 

  1. El Khwad M, Stetzer B, Moore RM, Kumar D, Mercer B, Arikat S, et al. Term human fetal membranes have a weak zone overlying the lower uterine pole and cervix before onset of labor. Biol Reprod. 2005;72:720–726
  2. Pandey V, Jaremko K, Moore RM, Mercer BM, Stetzer B, Kumar D, et al. The force required to rupture fetal membranes paradoxically increases with acute in vitro repeated stretching. Am J Obstet Gynecol. 2007;196:165.e1-7
  3. El Khwad M, Pandey V, Stetzer B, Mercer BM, Kumar D, Fox J, et al. Fetal membranes from term vaginal deliveries have a zone of weakness exhibiting characteristics of apoptosis and remodeling. J Soc Gynecol Investig. 2006;13:191–195
  4. Arikat S, Novince RW, Mercer BM, Kumar D, Fox JM, Mansour JM, et al. Separation of amnion from choriodecidua is an integral event to the rupture of normal term fetal membranes and constitutes a significant component of the work required. Am J Obstet Gynecol. 2006;194:211–217
  5. Meinert M, Eriksen GV, Petersen AC, Helmig RB, Laurent C, Uldbjerg N, et al. Proteoglycans and hyaluronan in human fetal membranes. Am J Obstet Gynecol. 2001;184:697–85
  6. Meinert M, Malmström A, Tufvesson E, Westergren-Thorsson G, Petersen AC, Laurent C, et al. Labour induces increased concentrations of biglycan and hyaluronan in human fetal membranes. Placenta. 2007;28:482–486
  7. Novince R, Strohl A, Mercer BM, Mansour JM, Moore RM, et al. A new methodology to measure strength of adherence of the fetal membrane components, amnion and the choriodecidua. Placenta. 2009;30:560–563
  8. McLaren J, Malak TM, Bell SC. Structural characteristics of term human fetal membranes prior to labor: identification of an area of altered morphology the cervix. Hum Reprod. 1999;14:237–241
  9. Sydorak RM, Hirose S, Sandberg PL, Filly RA, Harrison MR, Farmer DL, et al. Chorioamniotic membrane separation following fetal surgery. J Perinatol. 2002;22:407–410
  10. Bromley B, Shipp TD, Benacerraf BR. Amnion–chorion separation after 17 weeks' gestation. Obstet Gynecol. 1999;94:1024–1026
  11. Ulm B, Ulm MR, Bernaschek G. Unfused amnion and chorion after 14 weeks of gestation: associated fetal structural and chromosomal abnormalities. Ultrasound Obstet Gynecol. 1999;13:392–395
  12. Graf JL, Bealer JF, Gibbs DL, Adzick NS, Harrison MR. Chorioamniotic membrane separation: a potentially lethal finding. Fetal Diagn Ther. 1997;12:81–84
  13. Levine D, Callen PW, Pender SG, McArdle CR, Messina L, Shekhar A, et al. Chorioamniotic separation after second-trimester genetic amniocentesis: importance and frequency. Radiology. 1998;209:175–181
  14. Lewi L, Hanssens M, Spitz B, Deprest J. Complete chorioamniotic membrane separation. Case report and review of the literature. Fetal Diagn Ther. 2004;19:78–82
  15. Moore RM, Mansour JM, Redline RW, Mercer BM, Moore JJ. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Placenta. 2006;27:1037–1051
  16. Maymon E, Romero R, Pacora P, Gervasi MT, Bianco K, Ghezzi F, et al. Evidence for the participation of interstitial collagenase (matrix metalloproteinase 1) in preterm premature rupture of membranes. Am J Obstet Gynecol. 2000;183:914–920
  17. Oxlund H, Helmig R, Halaburt JT, Uldbjerg N. Biomechanical analysis of human chorioamniotic membranes. Eur J Obstet Gynecol Reprod Biol. 1990;34:247–255
  18. Helmig R, Oxlund H, Petersen LK, Uldbjerg N. Different biomechanical properties of human fetal membranes obtained before and after delivery. Eur J Obstet Gynecol Reprod Biol. 1993;48:183–189
  19. Uldbjerg N, Danielsen CC. A study of the interaction in vitro between type I collagen and a small dermatan sulphate proteoglycan. Biochem J. 1988;251:643–648
  20. Danielson KG, Baribault H, Holmes DF, Graham H, Kadler KE, Iozzo RV. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol. 1997;136:729–743
  21. Roughley PJ, Lee ER. Cartilage proteoglycans: structure and potential functions. Microsc Res Tech. 1994;28:385–397

☆ Presentation: Annual Meeting of the SGI, San Diego, CA, March 29, 2008.

PII: S0143-4004(09)00335-X

doi: 10.1016/j.placenta.2009.10.012

Placenta
Volume 31, Issue 1 , Pages 18-24 , January 2010

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