Placenta
Volume 31, Issue 1 , Pages 25-31 , January 2010

Increase in placental apolipoprotein D as an adaptation to human gestational diabetes

  • A. Navarro

      Affiliations

    • Department of Morphology and Cellular Biology, University of Oviedo, Oviedo, Spain
    • ,
  • A. Alonso

      Affiliations

    • Department of Functional Biology-Physiology Area, University of Oviedo, Oviedo, Spain
    • ,
  • P. Garrido

      Affiliations

    • Department of Functional Biology-Physiology Area, University of Oviedo, Oviedo, Spain
    • ,
  • C. González

      Affiliations

    • Department of Functional Biology-Physiology Area, University of Oviedo, Oviedo, Spain
    • ,
  • C. González del Rey

      Affiliations

    • Pathology Department. Medical Center of Asturias, Oviedo, Spain
    • ,
  • C. Ordoñez

      Affiliations

    • Department of Morphology and Cellular Biology, University of Oviedo, Oviedo, Spain
    • ,
  • J. Tolivia

      Affiliations

    • Department of Morphology and Cellular Biology, University of Oviedo, Oviedo, Spain
    • Corresponding Author InformationCorrespondence to: Tolivia J, Dpto. Morfología y Biología Celular, 8a Planta Facultad de Medicina, Universidad de Oviedo, c/Julián Clavería s/n, Oviedo 33006, Spain. Tel.: +34 985 103061; fax: +34 985 103618.

,Accepted 3 November 2009.

References 

  1. Rassart E, Bedirian A, Do Carmo S, Guinard O, Sirois J, Terrisse L, et al. Apolipoprotein D. Biochim Biophys Acta. 2000;1482:185–198
  2. Drayna D, Fielding C, McLean J, Baer B, Castro G, Chen E, et al. Cloning and expression of human apolipoprotein D cDNA. J Biol Chem. 1986;261:16535–16539
  3. Provost PR, Villeneuve L, Weech PK, Milne RW, Marcel YL, Rassart E. Localization of the major sites of rabbit apolipoprotein D gene transcription by in situ hybridization. J Lipids Res. 1991;32:1959–1970
  4. Søiland H, Søreide K, Janssen EA, Körner H, Baak JP, Søreide JA. Emerging concepts of apolipoprotein D with possible implications for breast cancer. Cell Oncol. 2007;29:195–209
  5. Simard J, Dauvois S, Haagensen DE, Levesque C, Merand Y, Labrie F. Regulation of progesterone binding breast cyst protein GCDFP 24 secretion by estrogens and androgens in human breast cancer cells: a new marker of steroid action in breast cancer. Endocrinology. 1990;12:3223–3231
  6. Simard J, Veilleux R, de Launoit Y, Haagensen DE, Labrie F. Stimulation of apolipoprotein D secretion by steroids coincides with inhibition of cell proliferation in human LNCaP prostate cancer cells. Cancer Res. 1991;51:4336–4341
  7. Simard J, de Launoit Y, Haagensen DE, Labrie F. Additive stimulatory action of glucocorticoids and androgens on basal and estrogen repressed apolipoprotein D messenger ribonucleic acid levels and secretion in human breast cancer cells. Endocrinology. 1992;130:1115–1121
  8. Lopez Boado YS, Puente XS, Alvarez S, Tolivia J, Binderup L, Lopez Otin C. Growth inhibition of human breast cancer cells by 1,25 dihydroxyvitamin D3 is accompanied by induction of apolipoprotein D expression. Cancer Res. 1994;57:4091–4097
  9. Blais Y, Sugimoto K, Carriere MC, Haagensen DE, Labrie F, Simard J. Interleukin 6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin 1 alpha on apolipoprotein D and GCDFP 15 expression in human breast cancer cells. Int J Cancer. 1995;62:732–737
  10. Do Carmo S, Séguin D, Milne R, Rassart E. Modulation of apolipoprotein D and apolipoprotein E mRNA expression by growth arrest and identification of key elements in the promoter. J Biol Chem. 2002;277:5514–5523
  11. Kalman J, McConathy W, Araoz C, Kasa P, Lacko AG. Apolipoprotein D in the aging brain and in Alzheimer's dementia. Neurol Res. 2000;22:330–336
  12. del Valle E, Navarro A, Astudillo A, Tolivia J. Apolipoprotein D expression in human brain reactive astrocytes. J Histochem Cytochem. 2003;51:1285–1290
  13. Thomas EA, Yao JK. Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D. Schizophr Res. 2007;89:147–153
  14. Ganfornina MD, Do Carmo S, Lora JM, Torres-Schumann S, Vogel M, Allhorn M, et al. Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell. 2008;7:506–515
  15. He X, Jittiwat J, Kim JH, Jenner AM, Farooqui AA, Patel SC, et al. Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury. Neurosci Lett. 2009;455:183–186
  16. Biri A, Onan A, Devrim E, Babacan F, Kavutcu M, Durak I. Oxidant status in maternal and cord plasma and placental tissue in gestational diabetes. Placenta. 2006;27:327–332
  17. West IC. Radicals and oxidative stress in diabetes. Diabet Med. 2000;17:171–180
  18. Wohaieb SA, Godin DV. Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment. Diabetes. 1987;36:1014–1018
  19. Coughlan MT, Vervaart PP, Permezel M, Georgiou HM, Rice GE. Altered placental oxidative stress status in gestational diabetes mellitus. Placenta. 2004;25:78–84
  20. Chen X, Scholl TO. Oxidative stress: changes in pregnancy and with gestational diabetes mellitus. Curr Diab Rep. 2005;5:282–288
  21. Bradford MM. A rapid and sensitive method for the quantization of microgram quantities utilizing the principle of protein dye binding. Anal Biochem. 1976;72:248–254
  22. Alonso A, Del Rey CG, Navarro A, Tolivia J, González CG. Effects of gestational diabetes mellitus on proteins implicated in insulin signaling in human placenta. Gynecol Endocrinol. 2006;22:526–535
  23. Díez-Itza I, Vizoso F, Merino AM, Sánchez LM, Tolivia J, Fernández J, et al. Expression and prognostic significance of apolipoprotein D in breast cancer. Am J Pathol. 1994;144:310–320
  24. Navarro A, Tolivia J, Astudillo A, del Valle E. Pattern of apolipoprotein D immunoreactivity in human brain. Neurosci Lett. 1998;254:17–20
  25. Tolivia J, Navarro A, Tolivia D. Differential staining of nerve cells and fibres for sections of paraffin-embedded material in mammalian central nervous system. Histochemistry. 1994;102:101–104
  26. Baker WA, Hitman GA, Hawrami K, Mccarthy MI, Riikonen A, Tuomilehtowolf E, et al. Apolipoprotein D gene polymorphism: a new genetic marker for type 2 diabetic subjects in Nauru and South India. Diabet Med. 1994;11:947–952
  27. Vijayaraghavan S, Hitman GA, Kopelman PG. Apolipoprotein D polymorphism: a genetic marker for obesity and hyperinsulinemia. J Clin Endocrinol Metab. 1994;79:568–570
  28. Do Carmo S, Fournier D, Mounier C, Rassart E. Human apolipoprotein D overexpression in transgenic mice induces insulin resistance and alters lipid metabolism. Am J Physiol Endocrinol Metab. 2009;296:E802–E811
  29. Kharb S. Lipid peroxidation in pregnancy with preeclampsia and diabetes. Gynecol Obstet Invest. 2000;50:113–116
  30. Casasco A, Calligaro A, Casasco M, Tateo S, Icaro Cornaglia A, Reguzzoni M, et al. Immunohistochemical localization of lipoperoxidation products in normal human placenta. Placenta. 1997;18:249–253
  31. Hnat MD, Meadows JW, Brockman DE, Pitzer B, Lyall F, Myatt L. Heat shock protein-70 and 4-hydroxy-2-nonenal adducts in human placental villous tissue of normotensive, preeclamptic and intrauterine growth restricted pregnancies. Am J Obstet Gynecol. 2005;193:836–840
  32. Smith KM, Lawn RM, Wilcox JN. Cellular localization of apolipoprotein D and lecithin:cholesterol acyltransferase mRNA in rhesus monkey tissues by in situ hybridization. J Lipid Res. 1990;31:995–1004
  33. Sanchez D, López-Arias B, Torroja L, Canal I, Wang X, Bastiani MJ, et al. Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Curr Biol. 2006;16:680–686
  34. Muffat J, Walker DW, Benzer S. Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. Proc Natl Acad Sci U S A. 2008;105:7088–7093
  35. Do Carmo S, Levros LC, Rassart E. Modulation of apolipoprotein D expression and translocation under specific stress conditions. Biochim Biophys Acta. 2007;1773:954–969
  36. Do Carmo S, Jacomy H, Talbot PJ, Rassart E. Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice. J Neurosci. 2008;28:10330–10338
  37. Yao JK, Thomas EA, Reddy RD, Keshavan MS. Association of plasma apolipoproteins D with RBC membrane arachidonic acid levels in schizophrenia. Schizophr Res. 2005;72:259–266
  38. Ordoñez C, Navarro A, Perez C, Astudillo A, Martínez E, Tolivia J. Apolipoprotein D expression in substantia nigra of Parkinson disease. Histol Histopathol. 2006;21:361–366
  39. Navarro A, Ordóñez C, Martínez E, Pérez C, Astudillo A, Tolivia J. Apolipoprotein D expression absence in degenerating neurons of human central nervous system. Histol Histopathol. 2008;23:995–1001
  40. Bitsanis D, Ghebremeskel K, Moodley T, Crawford MA, Djahanbakhch O. Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids. Lipids. 2006;41:341–346
  41. Navarro A, Tolivia J. The involvement of apolipoprotein D in pathologies affecting the nervous system. Rev Neurol. 2004;38:1166–1175
  42. Belloir B, Kövari E, Surini-Demiri M, Savioz A. Altered apolipoprotein D expression in the brain of patients with Alzheimer disease. J Neurosci Res. 2001;64:61–69
  43. Thomas EA, Dean B, Pavey G, Sutcliffe JG. Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: implications for the pathophysiology of psychiatric disorders. Proc Natl Acad Sci U S A. 2001;98:4066–4071
  44. Thomas EA, Laws SM, Sutcliffe JG, Harper C, Dean B, McClean C, et al. Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. Biol Psychiatry. 2003;54:136–141

PII: S0143-4004(09)00346-4

doi: 10.1016/j.placenta.2009.11.002

Placenta
Volume 31, Issue 1 , Pages 25-31 , January 2010

Article Tools

* Image Usage & Resolution