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Volume 31, Issue 3 , Pages 197-202 , March 2010

Decreased Placental Methylation at the H19/IGF2 Imprinting Control Region is Associated with Normotensive Intrauterine Growth Restriction but not Preeclampsia

D.K. Bourque
- Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
- Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada
L. Avila
- Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
- Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada
M. Peñaherrera
- Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
- Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada
P. von Dadelszen
- Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada
- Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, University of British Columbia, Vancouver, BC, Canada
W.P. Robinson
- Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
- Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada
- Corresponding author. Department of Medical Genetics, University of British Columbia, Child & Family Research Institute, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada. Tel.: +1 604 875 3229.

,Accepted 5 December 2009.

Intra-placental correlation for percent methylation at the H19/IGF2 ICR. The methylation values as measured by SNuPE from two separate sampling sites from one placenta were correlated (r=0.56, p<0.

Intra-placental correlation for percent methylation at the H19/IGF2 ICR. The methylation values as measured by SNuPE from two separate sampling sites from one placenta were correlated (r=0.56, p<0.0001). Percent methylation at C10 and C12 were averaged to obtain a single methylation value for each sample.
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Inter-group comparisons for percent methylation at the H19/IGF2 ICR. There is a significant reduction in mean methylation (average of two sites measured by SNuPE) in placental villi associated with no

Inter-group comparisons for percent methylation at the H19/IGF2 ICR. There is a significant reduction in mean methylation (average of two sites measured by SNuPE) in placental villi associated with normotensive IUGR compared to controls (p<0.01), PET (p<0.01), and PET+IUGR (p<0.01) pregnancies.
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