« Previous
Next »
Placenta
Volume 31, Issue 3
, Pages 230-239
, March 2010
Fatty acids alter glycerolipid metabolism and induce lipid droplet formation, syncytialisation and cytokine production in human trophoblasts with minimal glucose effect or interaction
References
- . The prevalence and impact of overweight and obesity in an Australian obstetric population. Med J Aust. 2006;184:56–59
- Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358:1991–2002
- Pregestational diabetes and pregnancy: an Australian experience. Diabetes Care. 2005;28:1260–1261
- . Perinatal mortality in Type 2 diabetes mellitus. Diabet Med. 2000;17:33–39
- . Poor pregnancy outcome in women with type 2 diabetes. Diabetes Care. 2005;28:323–328
- . Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur J Clin Nutr. 2000;54(Suppl. 1):S47–S51
- . Maternal serum triglyceride, glucose tolerance, and neonatal birth weight ratio in pregnancy. Diabetes Care. 1995;18:1550–1556
- . The hyperlipidemia of pregnancy in normal and complicated pregnancies. Am J Obstet Gynecol. 1979;133:165–170
- . Serum lipid, lipoprotein and apolipoprotein changes in gestational diabetes mellitus: a cross-sectional and prospective study. J Clin Pathol. 1996;49:634–637
- . Pregnancy-associated hypertriglyceridemia in normal and diabetic women. Differences in insulin-dependent, non-insulin-dependent, and gestational diabetes. Diabetes. 1982;31:1092–1097
- . Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. J Clin Endocrinol Metab. 2002;87:4231–4237
- . Association of elevated free fatty acids during late pregnancy with preterm delivery. Obstet Gynecol. 2008;112:297–303
- . Maternal and fetal fatty acid profile in normal and intrauterine growth restriction pregnancies with and without preeclampsia. Pediatr Res. 2008;64:615–620
- Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care. 2008;31:1858–1863
- . Morphometric study of placental villi and vessels in women with mild hyperglycemia or gestational or overt diabetes. Diabetes Res Clin Pract. 2007;78:65–71
- . Placental pathology in women with type 1 diabetes and in a control group with normal and large-for-gestational-age infants. Placenta. 2003;24:819–825
- Hyperinsulinism, neonatal obesity and placental immaturity in infants born to women with one abnormal glucose tolerance test value. J Perinat Med. 1998;26:27–36
- . Quantitative investigations of placental terminal villi in maternal diabetes mellitus by scanning and transmission electron microscopy. Tohoku J Exp Med. 1992;167:247–257
- . Effects of gestational diabetes on human placental glucose uptake, transfer, and utilisation. Diabetologia. 2000;43:576–582
- . Carbohydrate and fat metabolism and related hormonal regulation in normal and diabetic placenta. Placenta. 2001;22:619–627
- . Placental metabolism and its regulation in health and diabetes. Mol Aspects Med. 1994;15:505–682
- . Sustained hyperglycemia in vitro down-regulates the GLUT1 glucose transport system of cultured human term placental trophoblast: a mechanism to protect fetal development?. FASEB J. 1998;12:1221–1231
- Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. 2008;29:274–281
- . Placental free-fatty-acid transfer and fetal adipose-tissue development: an explantation of fetal adiposity in infants of diabetic mothers. Lancet. 1974;2:498–499
- . The effects of diabetes on placental lipase activity in the rat and human. Pediatr Res. 1991;30:541–543
- . Triglyceride hydrolase activities and expression of fatty acid binding proteins in the human placenta in pregnancies complicated by intrauterine growth restriction and diabetes. J Clin Endocrinol Metab. 2004;89:4607–4614
- . Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression. J Lipid Res. 2006;47:2581–2588
- . Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus. Am J Obstet Gynecol. 2009;201:209;e201–209 e210
- . Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?. Diabetes. 1996;45:273–283
- A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes. 2004;53:1007–1019
- Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology. 2003;144:4154–4163
- . Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology. 1986;118:1567–1582
- . New method for GC/FID and GC-C-IRMS analysis of plasma free fatty acid concentration and isotopic enrichment. J Chromatogr B Analyt Technol Biomed Life Sci. 2008;873:95–101
- Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells. Am J Physiol. 1999;277:E521–E528
- Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1. Diabetes. 2004;53:1733–1742
- . Glucose uptake, utilization, and transfer by the human placenta as functions of maternal glucose concentration. Pediatr Res. 1986;20:269–273
- . Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases. Am J Physiol Endocrinol Metab. 2003;284:E1098–E1105
- High activity of fatty acid oxidation enzymes in human placenta: implications for fetal-maternal disease. J Inherit Metab Dis. 2003;26:385–392
- . The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem. 1997;244:1–14
- Insulin and fatty acids regulate the expression of the fat droplet-associated protein adipophilin in primary human trophoblasts. Am J Obstet Gynecol. 2005;193:1716–1723
- . Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice. Endocrinology. 2007;148:3625–3634
- . Peroxisome proliferator-activated receptor-gamma and retinoid X receptor signaling regulate fatty acid uptake by primary human placental trophoblasts. J Clin Endocrinol Metab. 2005;90:4267–4275
- . The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor. J Clin Endocrinol Metab. 2003;88:6056–6062
- . Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. Mol Hum Reprod. 2008;14:491–499
- . Histological, histochemical and electron microscopic changes of the placenta induced by maternal exposure to hyperthermia in the rat. Int J Hyperthermia. 2005;21:29–44
- . Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?. J Gastroenterol Hepatol. 2009;24:703–706
- . Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency. Am J Physiol Endocrinol Metab. 2007;293:E24–E30
- Upregulation of cellular triacylglycerol - free fatty acid cycling by oleate is associated with long-term serum-free survival of human breast cancer cells. Biochem Cell Biol. 2007;85:301–310
- . Human placenta secretes apolipoprotein B-100-containing lipoproteins. J Biol Chem. 2004;279:55271–55276
- . Gestational diabetes induces placental genes for chronic stress and inflammatory pathways. Diabetes. 2003;52:2951–2958
PII: S0143-4004(09)00403-2
doi: 10.1016/j.placenta.2009.12.013
© 2009 Elsevier Ltd. All rights reserved.
« Previous
Next »
Placenta
Volume 31, Issue 3
, Pages 230-239
, March 2010
