Placenta
Volume 31 , Pages S60-S65 , March 2010

Review: Placental Programming of Postnatal Diabetes and Impaired Insulin Action after IUGR

  • K.L. Gatford

      Affiliations

    • Research Centre for Early Origins of Health and Disease, Robinson Institute, and School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 8 8303 4158; fax: +61 8 8303 4099.
    • ,
  • R.A. Simmons

      Affiliations

    • Department of Pediatrics, School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    • ,
  • M.J. De Blasio

      Affiliations

    • Research Centre for Early Origins of Health and Disease, Robinson Institute, and School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    • ,
  • J.S. Robinson

      Affiliations

    • Research Centre for Early Origins of Health and Disease, Robinson Institute, and School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    • ,
  • J.A. Owens

      Affiliations

    • Research Centre for Early Origins of Health and Disease, Robinson Institute, and School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia

,Accepted 14 December 2009.

  • Image Result

    IUGR and insulin action in humans. Restriction of growth before birth enhances insulin sensitivity in neonates with reversal to impaired insulin sensitivity by adulthood. Insulin secretion is impaired

    IUGR and insulin action in humans. Restriction of growth before birth enhances insulin sensitivity in neonates with reversal to impaired insulin sensitivity by adulthood. Insulin secretion is impaired from early postnatal life, and together these contribute to increased risks of T2D in the adult who was small at birth. Effects of IUGR/SGA are relative to AGA individuals, who are indicated by the thick dashed line. The dotted vertical line indicates birth.

  • Image Result
    PR and insulin action in sheep and rats. PR rats and sheep exhibit similar changes in insulin secretion and sensitivity with ageing as IUGR humans, including decreasing insulin sensitivity and impaire

    PR and insulin action in sheep and rats. PR rats and sheep exhibit similar changes in insulin secretion and sensitivity with ageing as IUGR humans, including decreasing insulin sensitivity and impaired insulin secretion. Effects of PR are relative to control individuals, who are indicated by the thick dashed line. The dotted vertical line indicates birth.

PII: S0143-4004(09)00405-6

doi: 10.1016/j.placenta.2009.12.015

Placenta
Volume 31 , Pages S60-S65 , March 2010

Article Tools

* Image Usage & Resolution