Placenta
Volume 31 , Pages S40-S46 , March 2010

Review: Sex specific programming: A critical role for the renal renin–angiotensin system

  • K.M. Moritz

      Affiliations

    • School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 7 3365 4598.
    • ,
  • J.S.M. Cuffe

      Affiliations

    • School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia
    • ,
  • L.B. Wilson

      Affiliations

    • School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia
    • ,
  • H. Dickinson

      Affiliations

    • Department of Physiology, Monash University, Clayton 3800, Australia
    • ,
  • M.E. Wlodek

      Affiliations

    • Department of Physiology, The University of Melbourne, Melbourne 3010, Australia
    • ,
  • D.G. Simmons

      Affiliations

    • School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia
    • ,
  • K.M. Denton

      Affiliations

    • Department of Physiology, Monash University, Clayton 3800, Australia

,Accepted 6 January 2010.

  • Image Result

    A contemporary view of the renin–angiotensin system. Abbreviations: ACE=angiotensin converting enzyme, ACE-2=angiotensin converting enzyme-2, AT1=angiotensin receptor type 1, AT2=angiotensin receptor

    A contemporary view of the renin–angiotensin system. Abbreviations: ACE=angiotensin converting enzyme, ACE-2=angiotensin converting enzyme-2, AT1=angiotensin receptor type 1, AT2=angiotensin receptor type-2, Ang 1–7=angiotensin 1–7, Ang 1–9=angiotensin 1–9, Mas-R=mas proto-oncogene receptor.

  • Image Result
    Placental renin, AT1 and AT2 receptor mRNA expression in rabbit placenta from male or female offspring at day 28 of a 32 day gestation from normotensive (sham) and hypertensive (2K–1W) mothers. The da

    Placental renin, AT1 and AT2 receptor mRNA expression in rabbit placenta from male or female offspring at day 28 of a 32 day gestation from normotensive (sham) and hypertensive (2K–1W) mothers. The data is presented as mean±sem with n>4 placenta per group from 4 different litters. In sham animals, there was no difference between sexes in expression of any gene. Two way ANOVA showed renin mRNA was significantly decreased by maternal hypertension in both sexes (P<0.01). However, the AT1 receptor expression was only increased in the placenta of female fetuses in hypertensive mothers (Psex × treat<0.05).

PII: S0143-4004(10)00022-6

doi: 10.1016/j.placenta.2010.01.006

Placenta
Volume 31 , Pages S40-S46 , March 2010

Article Tools

* Image Usage & Resolution