Placenta
Volume 31, Issue 4 , Pages 320-326 , April 2010

Changes in endovascular trophoblast invasion and spiral artery remodelling at term in a transgenic preeclamptic rat model

  • N. Geusens

      Affiliations

    • Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    • Corresponding Author InformationCorresponding author at: University Hospital, Herestraat 49 box 611, B-3000 Leuven, Belgium. Tel.: +32 16 346195; fax: +32 16 346215.
    • ,
  • L. Hering

      Affiliations

    • Max Delbrueck Center of Molecular Medicine, Berlin, Germany
    • ,
  • S. Verlohren

      Affiliations

    • Department of Obstetrics, Charité University Medicine, Berlin, Germany
    • Max Delbrueck Center of Molecular Medicine, Berlin, Germany
    • ,
  • C. Luyten

      Affiliations

    • Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    • ,
  • K. Drijkoningen

      Affiliations

    • Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    • ,
  • M. Taube

      Affiliations

    • Max Delbrueck Center of Molecular Medicine, Berlin, Germany
    • ,
  • L. Vercruysse

      Affiliations

    • Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    • ,
  • M. Hanssens

      Affiliations

    • Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    • ,
  • R. Dechend

      Affiliations

    • Department of Obstetrics, Charité University Medicine, Berlin, Germany
    • Department of Cardiology, Charité University Medicine and Helios-Klinikum Berlin, Germany
    • ,
  • R. Pijnenborg

      Affiliations

    • Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium

,Accepted 14 January 2010.

References 

  1. Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu. 1972;1:177–191
  2. Caluwaerts S, Vercruysse L, Luyten C, Pijnenborg R. Endovascular trophoblast invasion and associated structural changes in uterine spiral arteries of the pregnant rat. Placenta. 2005;26:574–584
  3. Bohlender J, Ganten D, Luft FC. Rats transgenic for human renin and human angiotensinogen as a model for gestational hypertension. J Am Soc Nephrol. 2000;11:2056–2061
  4. Dechend R, Gratze P, Wallukat G, Shagdarsuren E, Plehm R, Brasen JH, et al. Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia. Hypertension. 2005;45:742–746
  5. Geusens N, Verlohren S, Luyten C, Taube M, Hering L, Vercruysse L, et al. Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia. Placenta. 2008;29:614–623
  6. Pijnenborg R, Vercuysse L, Hanssens M. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta. 2006;27:939–958
  7. Pijnenborg R, Vercruysse L, Hanssens M, Van Assche FA. Trophoblast invasion in pre-eclampsia and other pregnancy disorders. In:  Lyall F,  Belfort M editor. Pre-eclampsia, etiology and clinical practice. Cambridge: Cambridge University Press; 2007;p. 3–19
  8. Robertson WB, Brosens I, Pijnenborg R, De Wolf F. The making of the placental bed. Eur J Obstet Gynecol Reprod Biol. 1984;18:255–266
  9. Meekins JW, Pijnenborg R, Hanssens M, McFadyen IR, van Assche A. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. Br J Obstet Gynaecol. 1994;101:669–674
  10. Beckstead JH. A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues. J Histochem Cytochem. 1994;42:1127–1134
  11. Verlohren S, Niehoff M, Hering L, Geusens N, Herse F, Tintu AN, et al. Uterine vascular function in a transgenic preeclampsia rat model. Hypertension. 2008;51:547–553
  12. Greenwood JD, Minhas K, Di Santo JP, di Santo JP, Makita M, Kiso Y, et al. Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells. Placenta. 2000;21:693–702
  13. Li XF, Charnock-Jones S, Zhang E, Hiby S, Malik S, Day K, et al. Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J Clin Endocrinol Metab. 2001;86:1823–1834
  14. Smith SD, Dunk CE, Aplin JD, Harris LK, Jones RL. Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy. Am J Pathol. 2009;174:1959–1971
  15. Simmons DG, Fortier AL, Cross JS. Diverse subtupes and developmental origins of trophoblast giant cells in the mouse placenta. Dev Biol. 2007;304:567–578
  16. Adamson SL, Lu Y, Whiteley KJ, Holmyard D, Hemberger M, Pfarrer C, et al. Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. Dev Biol. 2002;250:358–373
  17. Verlohren S, Niehoff M, Hering L, Geusens N, Herse F, Le Noble F, et al. Characterization of a transgenic rat model for preeclampsia – new insights. Hypertens Pregnancy. 2008;27:512

PII: S0143-4004(10)00037-8

doi: 10.1016/j.placenta.2010.01.011

Placenta
Volume 31, Issue 4 , Pages 320-326 , April 2010

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