Placenta
Volume 31, Issue 5 , Pages 456-459 , May 2010

Comparison of l-serine uptake by human placental microvillous membrane vesicles and placental villous fragments

  • A.P. Brand

      Affiliations

    • University of Southampton, School of Medicine, UK
    • ,
  • S.L. Greenwood

      Affiliations

    • Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, Manchester Academic Health Science Centre, University of Manchester, St. Mary's Hospital, Manchester, UK
    • ,
  • J.D. Glazier

      Affiliations

    • Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, Manchester Academic Health Science Centre, University of Manchester, St. Mary's Hospital, Manchester, UK
    • ,
  • E.J. Bennett

      Affiliations

    • University of Southampton, School of Medicine, UK
    • ,
  • K.M. Godfrey

      Affiliations

    • University of Southampton, School of Medicine, UK
    • ,
  • C.P. Sibley

      Affiliations

    • Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, Manchester Academic Health Science Centre, University of Manchester, St. Mary's Hospital, Manchester, UK
    • ,
  • M.A. Hanson

      Affiliations

    • University of Southampton, School of Medicine, UK
    • ,
  • R.M. Lewis

      Affiliations

    • University of Southampton, School of Medicine, UK
    • Corresponding Author InformationCorresponding author. Institute of Developmental Sciences, University of Southampton, MP 887 Southampton General Hospital, Tremona Road, SO16 6YD, UK. Tel.: +44 2380798663.

,Accepted 28 January 2010.

References 

  1. Glazier JD, Sibley CP. In vitro methods for studying human placental amino acid transport: placental plasma membrane vesicles. Methods Mol Med. 2006;122:241–252
  2. Greenwood SL, Sibley CP. In vitro methods for studying human placental amino acid transport placental villous fragments. Methods Mol Med. 2006;122:253–264
  3. Ayuk PT, Sibley CP, Donnai P, D'Souza S, Glazier JD. Development and polarization of cationic amino acid transporters and regulators in the human placenta. Am J Physiol Cell Physiol. 2000;278:C1162–C1171
  4. Lewis RM, Glazier J, Greenwood SL, Bennett EJ, Godfrey KM, Jackson AA, et al. l-serine uptake by human placental microvillous membrane vesicles. Placenta. 2007;28:445–452
  5. Godfrey KM, Matthews N, Glazier J, Jackson A, Wilman C, Sibley CP. Neutral amino acid uptake by the microvillous plasma membrane of the human placenta is inversely related to fetal size at birth in normal pregnancy. J Clin Endocrinol Metab. 1998;83:3320–3326
  6. Johansson M, Karlsson L, Wennergren M, Jansson T, Powell TL. Activity and protein expression of Na+/K+ ATPase are reduced in microvillous syncytiotrophoblast plasma membranes isolated from pregnancies complicated by intrauterine growth restriction. J Clin Endocrinol Metab. 2003;88:2831–2837
  7. Magnusson AL, Waterman IJ, Wennergren M, Jansson T, Powell TL. Triglyceride hydrolase activities and expression of fatty acid binding proteins in the human placenta in pregnancies complicated by intrauterine growth restriction and diabetes. J Clin Endocrinol Metab. 2004;89:4607–4614
  8. Glazier JD, Jones CJ, Sibley CP. Purification and Na+ uptake by human placental microvillus membrane vesicles prepared by three different methods. Biochim Biophys Acta. 1988;945:127–134
  9. Illsley NP, Wang ZQ, Gray A, Sellers MC, Jacobs MM. Simultaneous preparation of paired, syncytial, microvillous and basal membranes from human placenta. Biochim Biophys Acta. 1990;1029:218–226
  10. Jimenez V, Henriquez M, Llanos P, Riquelme G. Isolation and purification of human placental plasma membranes from normal and pre-eclamptic pregnancies. A comparative study. Placenta. 2004;25:422–437
  11. Cleal JK, Lewis RM. The mechanisms and regulation of placental amino acid transport to the human foetus. J Neuroendocrinol. 2008;20:419–426
  12. Ling R, Bridges CC, Sugawara M, Leibach FH, Prasad PD, Ganapathy V, et al. Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A. Biochim Biophys Acta. 2001;1512:15–21
  13. Hatanaka T, Hatanaka Y, Tsuchida J, Ganapathy V, Setou M. Amino acid transporter ATA2 is stored at the trans-golgi network and released by insulin stimulus in adipocytes. J Biol Chem. 2006;281:39273–39284
  14. Parrott MS, von Versen-Hoeynck F, Ness RB, Markovic N, Roberts JM. System A amino acid transporter activity in term placenta is substrate specific and inversely related to amino acid concentration. Reprod Sci. 2007;14:687–693
  15. Hatanaka T, Huang W, Ling R, Prasad PD, Sugawara M, Leibach FH, et al. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim Biophys Acta. 2001;1510:10–17
  16. Desforges M, Mynett KJ, Jones RL, Greenwood SL, Westwood M, Sibley CP, et al. The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane. J Physiol. 2009;587:61–72
  17. Hoeltzli SD, Smith CH. Alanine transport systems in isolated basal plasma membrane of human placenta. Am J Physiol. 1989;256:C630–C637
  18. Johnson LW, Smith CH. Neutral amino acid transport systems of microvillous membrane of human placenta. Am J Physiol. 1988;254:C773–C780
  19. Mahendran D, Byrne S, Donnai P, D'Souza SW, Glazier JD, Jones CJ, et al. Na+ transport, H+ concentration gradient dissipation, and system A amino acid transporter activity in purified microvillous plasma membrane isolated from first-trimester human placenta: comparison with the term microvillous membrane. Am J Obstet Gynecol. 1994;171:1534–1540
  20. Mahendran D, Donnai P, Glazier JD, D'Souza SW, Boyd RD, Sibley CP. Amino acid (system A) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babies. Pediatr Res. 1993;34:661–665
  21. Shibata E, Hubel CA, Powers RW, von Versen-Hoeynck F, Gammill H, Rajakumar A, et al. Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants. Placenta. 2008;29:879–882
  22. Jansson T, Scholtbach V, Powell TL. Placental transport of leucine and lysine is reduced in intrauterine growth restriction. Pediatr Res. 1998;44:532–537
  23. Roos S, Jansson N, Palmberg I, Saljo K, Powell TL, Jansson T. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. J Physiol. 2007;582:449–459

PII: S0143-4004(10)00042-1

doi: 10.1016/j.placenta.2010.01.016

Placenta
Volume 31, Issue 5 , Pages 456-459 , May 2010

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