Placenta
Volume 31, Issue 5 , Pages 418-422 , May 2010

Maternal muscle mass may influence system A activity in human placenta

  • R.M. Lewis

      Affiliations

    • Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    • Corresponding Author InformationCorresponding author. Institute of Developmental Sciences, University of Southampton, MP 887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. Tel.: +44 2380798663; fax: +44 2380795255.
    • ,
  • S.L. Greenwood

      Affiliations

    • Maternal and Fetal Health Research Group, Manchester Academic Health Science Centre, School of Clinical and Laboratory Sciences, University of Manchester, UK
    • ,
  • J.K. Cleal

      Affiliations

    • Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    • ,
  • S.R. Crozier

      Affiliations

    • MRC Epidemiology Resource Centre, University of Southampton, UK
    • ,
  • L. Verrall

      Affiliations

    • Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    • ,
  • H.M. Inskip

      Affiliations

    • MRC Epidemiology Resource Centre, University of Southampton, UK
    • ,
  • I.T. Cameron

      Affiliations

    • Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    • ,
  • C. Cooper

      Affiliations

    • MRC Epidemiology Resource Centre, University of Southampton, UK
    • NIHR Nutrition Biomedical Research Unit, Southampton University Hospitals NHS Trust, UK
    • ,
  • C.P. Sibley

      Affiliations

    • Maternal and Fetal Health Research Group, Manchester Academic Health Science Centre, School of Clinical and Laboratory Sciences, University of Manchester, UK
    • ,
  • M.A. Hanson

      Affiliations

    • Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    • NIHR Nutrition Biomedical Research Unit, Southampton University Hospitals NHS Trust, UK
    • ,
  • K.M. Godfrey

      Affiliations

    • MRC Epidemiology Resource Centre, University of Southampton, UK
    • NIHR Nutrition Biomedical Research Unit, Southampton University Hospitals NHS Trust, UK

,Accepted 1 February 2010.

  • Image Result

    Uptake of 14C-Methyl AIB into placental villous fragments in the presence (total uptake) or absence (Na free uptake) of Na+ over time. This demonstrates that Na+-dependent uptake is linear with time b

    Uptake of 14C-Methyl AIB into placental villous fragments in the presence (total uptake) or absence (Na free uptake) of Na+ over time. This demonstrates that Na+-dependent uptake is linear with time between 10 and 20 min. System A is a Na+-dependent transporter and its activity was determined from the difference between total uptake and Na+-independent uptake. Data are mean (95% CI), n = 12.

  • Image Result
    Placental system A activity at birth was associated with pre-pregnant maternal upper arm muscle mass. r = 0.27, P = 0.007, n = 103.

    Placental system A activity at birth was associated with pre-pregnant maternal upper arm muscle mass. r = 0.27, P = 0.007, n = 103.

PII: S0143-4004(10)00054-8

doi: 10.1016/j.placenta.2010.02.001

Placenta
Volume 31, Issue 5 , Pages 418-422 , May 2010

Article Tools

* Image Usage & Resolution