Placenta
Volume 31, Issue 9 , Pages 818-824 , September 2010

Expression of Liver X Receptors in Pregnancies Complicated by Preeclampsia

  • M.S. Weedon-Fekjær

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
    • Corresponding Author InformationCorresponding author. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P. O. Box. 1946, Blindern, 0316 Oslo, Norway. Tel.: +47 97684482 (mobile); fax: +47 22851341.
  • ,
  • G.M. Johnsen

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
  • ,
  • E.H. Anthonisen

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
  • ,
  • M. Sugulle

      Affiliations

    • Department of Obstetrics and Gynaecology, Oslo University Hospital, Ulleval, Norway
  • ,
  • H.I. Nebb

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
  • ,
  • A.K. Duttaroy

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
  • ,
  • A.C. Staff

      Affiliations

    • Department of Obstetrics and Gynaecology, Oslo University Hospital, Ulleval, Norway
    • Faculty of Medicine, University of Oslo, Norway

,Accepted 24 June 2010.

References 

  1. Myatt L. Role of placenta in preeclampsia. Endocrine. 2002;1:103–111
  2. Lorentzen B, Endresen MJ, Henriksen T, Clausen T. Fasting serum free fatty acids and triglycerides are increased before 20 weeks of gestation in women who later develop preeclampsia. Hypertens Pregnancy. 1994;13:103–109
  3. Hubel CA, McLaughlin MK, Evans RW, Hauth BA, Sims CJ, Roberts JM. Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum. Am J Obstet Gynecol. 1996;3:975–982
  4. Ogura K, Miyatake T, Fukui O, Nakamura T, Kameda T, Yoshino G. Low-density lipoprotein particle diameter in normal pregnancy and preeclampsia. J Atheroscler Thromb. 2002;1:42–47
  5. Qiu C, Phung TT, Vadachkoria S, Muy-Rivera M, Sanchez SE, Williams MA. Oxidized low-density lipoprotein (Oxidized LDL) and the risk of preeclampsia. Physiol Res. 2006;5:491–500
  6. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996;6602:728–731
  7. Tontonoz P, Mangelsdorf DJ. Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol. 2003;6:985–993
  8. Ulven SM, Dalen KT, Gustafsson JA, Nebb HI. LXR is crucial in lipid metabolism. Prostaglandins Leukot Essent Fatty Acids. 2005;1:59–63
  9. Weedon-Fekjaer MS, Duttaroy AK, Nebb HI. Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line. Placenta. 2005;10:721–728
  10. Pavan L, Hermouet A, Tsatsaris V, Therond P, Sawamura T, Evain-Brion D, et al. Lipids from oxidized low-density lipoprotein modulate human trophoblast invasion: involvement of nuclear liver X receptors. Endocrinology. 2004;10:4583–4591
  11. Burke KT, Colvin PL, Myatt L, Graf GA, Schroeder F, Woollett LA. Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden syrian hamster. J Lipid Res. 2009;
  12. Lindegaard ML, Wassif CA, Vaisman B, Amar M, Wasmuth EV, Shamburek R, et al. Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome. Hum Mol Genet. 2008;23:3806–3813
  13. ACOG practice bulletin . Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Int J Gynaecol Obstet. 2002;1:67–75American College of Obstetricians and Gynecologists
  14. Skjaerven R, Gjessing HK, Bakketeig LS. Birthweight by gestational age in Norway. Acta Obstet Gynecol Scand. 2000;6:440–449
  15. Johnsen SL, Rasmussen S, Wilsgaard T, Sollien R, Kiserud T. Longitudinal reference ranges for estimated fetal weight. Acta Obstet Gynecol Scand. 2006;3:286–297
  16. Harsem NK, Staff AC, He L, Roald B. The decidual suction method: a new way of collecting decidual tissue for functional and morphological studies. Acta Obstet Gynecol Scand. 2004;8:724–730
  17. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;4:402–408
  18. Pipe NG, Smith T, Halliday D, Edmonds CJ, Williams C, Coltart TM. Changes in fat, fat-free mass and body water in human normal pregnancy. Br J Obstet Gynaecol. 1979;12:929–940
  19. Poston L. Leptin and preeclampsia. Semin Reprod Med. 2002;2:131–138
  20. Fournier T, Handschuh K, Tsatsaris V, Guibourdenche J, Evain-Brion D. Role of nuclear receptors and their ligands in human trophoblast invasion. J Reprod Immunol. 2008;2:161–170
  21. Henry-Berger J, Mouzat K, Baron S, Bernabeu C, Marceau G, Saru JP, et al. Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR. Biol Reprod. 2008;6:968–975
  22. Plosch T, van Straten EM, Kuipers F. Cholesterol transport by the placenta: placental liver X receptor activity as a modulator of fetal cholesterol metabolism?. Placenta. 2007;7:604–610
  23. Stefulj J, Panzenboeck U, Becker T, Hirschmugl B, Schweinzer C, Lang I, et al. Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1. Circ Res. 2009;5:600–608
  24. Watanabe Y, Jiang S, Takabe W, Ohashi R, Tanaka T, Uchiyama Y, et al. Expression of the LXRalpha protein in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2005;3:622–627
  25. Kim KH, Yoon JM, Choi AH, Kim WS, Lee GY, Kim JB. Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1. Mol Endocrinol. 2009;4:466–474
  26. Baranowski M. Biological role of liver X receptors. J Physiol Pharmacol. 2008;31–55
  27. Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology. 2008;2:556–567
  28. Laivuori H, Gallaher MJ, Collura L, Crombleholme WR, Markovic N, Rajakumar A, et al. Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. Mol Hum Reprod. 2006;9:551–556
  29. Choe SS, Choi AH, Lee JW, Kim KH, Chung JJ, Park J, et al. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes. 2007;6:1534–1543
  30. Lorentzen B, Drevon CA, Endresen MJ, Henriksen T. Fatty acid pattern of esterified and free fatty acids in sera of women with normal and pre-eclamptic pregnancy. Br J Obstet Gynaecol. 1995;7:530–537
  31. Wang Y, Walsh SW, Kay HH. Placental tissue levels of nonesterified polyunsaturated fatty acids in normal and preeclamptic pregnancies. Hypertens Pregnancy. 2005;3:235–245
  32. Kamei Y, Miura S, Suganami T, Akaike F, Kanai S, Sugita S, et al. Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor. Endocrinology. 2008;5:2293–2305
  33. Oosterveer MH, van Dijk TH, Grefhorst A, Bloks VW, Havinga R, Kuipers F, et al. Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice. J Biol Chem. 2008;37:25437–25445
  34. Marcil V, Delvin E, Sane AT, Tremblay A, Levy E. Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors. Cardiovasc Res. 2006;3:473–482
  35. Costet P, Luo Y, Wang N, Tall AR. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000;36:28240–28245
  36. Hoekstra M, Kruijt JK, Van EM, Van Berkel TJ. Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells. J Biol Chem. 2003;28:25448–25453
  37. Sitras V, Paulssen RH, Gronaas H, Leirvik J, Hanssen TA, Vartun A, et al. Differential placental gene expression in severe preeclampsia. Placenta. 2009;

PII: S0143-4004(10)00245-6

doi: 10.1016/j.placenta.2010.06.015

Placenta
Volume 31, Issue 9 , Pages 818-824 , September 2010