Placenta
Volume 31, Issue 9 , Pages 796-802 , September 2010

Expression of Regulatory T cell (Treg) Activation Markers in Endometrial Tissues from Early and Late Pregnancy in the Feline Immunodeficiency Virus (FIV)-Infected Cat

  • N.N. Lockett

      Affiliations

    • Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    • ,
  • V.L. Scott

      Affiliations

    • Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    • ,
  • C.E. Boudreaux

      Affiliations

    • Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    • ,
  • B.T. Clay

      Affiliations

    • Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    • ,
  • S.B. Pruett

      Affiliations

    • Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA
    • ,
  • P.L. Ryan

      Affiliations

    • Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    • ,
  • K.S. Coats

      Affiliations

    • Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    • Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA
    • Corresponding Author InformationCorresponding author. Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA. Tel.: +1 662 325 8252.

,Accepted 29 June 2010.

References 

  1. Maloy KJ, Salaun L, Cahill R, Dougan G, Saunders NJ, Powrie F. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med. 2003;197(1):111–119
  2. Michaelsson J, Mold JE, McCune JM, Nixon DF. Regulation of T cell responses in the developing human fetus. J Immunol. 2006;176(10):5741–5748
  3. Zenclussen AC, Gerlof K, Zenclussen ML, Sollwedel A, Bertoja AZ, Ritter T, et al. Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol. 2005;166(3):811–822
  4. Mold JE, Michaelsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008;322(5907):1562–1565
  5. Chao KH, Wu MY, Yang JH, Chen SU, Yang YS, Ho HN. Expression of the interleukin-2 receptor alpha (CD25) is selectively decreased on decidual CD4+ and CD8+ T lymphocytes in normal pregnancies. Mol Hum Reprod. 2002;8(7):667–673
  6. Heikkinen J, Mottonen M, Alanen A, Lassila O. Phenotypic characterization of regulatory T cells in the human decidua. Clin Exp Immunol. 2004;136(2):373–378
  7. Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology. 2004;112(1):38–43
  8. Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod. 2004;10(5):347–353
  9. Zhu XY, Zhou YH, Wang MY, Jin LP, Yuan MM, Li DJ. Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4+CD25+ regulatory T cells to rescue abortion-prone fetuses. Biol Reprod. 2005;72(2):338–345
  10. Lankford S, Petty C, LaVoy A, Reckling S, Tompkins W, Dean GA. Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells. Vet Immunol Immunopathol. 2008;122(1–2):159–166
  11. Vahlenkamp TW, Tompkins MB, Tompkins WA. Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells. J Immunol. 2004;172(8):4752–4761
  12. Joshi A, Garg H, Tompkins MB, Tompkins WA. Preferential feline immunodeficiency virus (FIV) infection of CD4+CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors. J Virol. 2005;79(8):4965–4976
  13. UNAIDS. Key facts by region – 2008. Report on the global AIDS epidemic; 2008.
  14. Rollins NC, Coovadia HM, Bland RM, Coutsoudis A, Bennish ML, Patel D, et al. Pregnancy outcomes in HIV-infected and uninfected women in rural and urban South Africa. J Acquir Immune Defic Syndr. 2007;44(3):321–328
  15. Anderson V, Carneiro M, Bulterys M, Douglas G, Polliotti B, Slikker W. Perinatal infections: HIV and co-infections in the placenta and therapeutic interventions – a workshop report. Placenta. 2001;22(Suppl. A):S34–S37Trophoblast Research 15
  16. Goldstein P, Smit R, Stevens M, Sever JL. Association between HIV in pregnancy and antiretroviral therapy including protease inhibitors and low birth weight infants. Infect Dis Obstet Gynecol. 2000;8:94–98
  17. D’Ubaldo C, Pezzotti P, Rezza G, Branca M, Ippolito G DIANAIDS Collaborative Study Group. Association between HIV-1 infection and miscarriage: a retrospective study. In: Diagnosi iniziale anomalie neoplastiche AIDS. AIDS. 1998;12:1087–1093
  18. Kumar RM, Uduman SA, Khurranna AK. Impact of maternal HIV-1 infection on perinatal outcome. Int J Gynaecol Obstet. 1995;49(2):137–143
  19. Massad LS, Springer G, Jacobson L, Watts H, Anastos K, Korn A, et al. Pregnancy rates and predictors of conception, miscarriage and abortion in US women with HIV. AIDS. 2004;18(2):281–286
  20. O’Neil LL, Burkhard MJ, Hoover EA. Frequent perinatal transmission of feline immunodeficiency virus by chronically infected cats. J Virol. 1996;70(5):2894–2901
  21. Rogers AB, Hoover EA. Maternal-fetal feline immunodeficiency virus transmission: timing and tissue tropisms. J Infect Dis. 1998;178(4):960–967
  22. Weaver CC, Burgess SC, Nelson PD, Wilkinson M, Ryan PL, Nail CA, et al. Placental immunopathology and pregnancy failure in the FIV-infected cat. Placenta. 2005;26(2–3):138–147
  23. Boudreaux CE, Lockett NN, Chemerys DN, Clay BT, Scott VL, Willeford B, et al. Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation. Vet Immunol Immunopathol. 2009;131(3–4):290–297
  24. Scott VL, Burgess SC, Shack LA, Lockett NN, Coats KS. Expression of CD134 and CXCR4 mRNA in term placentas from FIV-infected and control cats. Vet Immunol Immunopathol. 2008;123(1–2):90–96
  25. Kaiser P, Rothwell L, Galyov EE, Barrow PA, Burnside J, Wigley P. Differential cytokine expression in avian cells in response to invasion by Salmonella typhimurium, Salmonella enteritidis and Salmonella gallinarum. Microbiology. 2000;146(12):3217–3226
  26. Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF, Petraglia F. Inflammation and pregnancy. Reprod Sci. 2009;16(2):206–215
  27. Shima T, Sasaki Y, Itoh M, Nakashima A, Ishii N, Sugamura K, et al. Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice. J Reprod immunol. 2010;85(2):121–129
  28. Chen Z, Herman AE, Matos M, Mathis D, Benoist C. Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med. 2005;202(10):1387–1397
  29. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol. 2003;3(3):199–210
  30. Boasso A, Vaccari M, Hryniewicz A, Fuchs D, Nacsa J, Cecchinato V, et al. Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection. J Virol. 2007;81(21):11593–11603
  31. Tompkins MB, Tompkins WA. Lentivirus-induced immune dysregulation. Vet Immunol Immunopathol. 2008;123(1–2):45–55
  32. Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med. 1996;183(6):2533–2540

PII: S0143-4004(10)00249-3

doi: 10.1016/j.placenta.2010.06.019

Placenta
Volume 31, Issue 9 , Pages 796-802 , September 2010

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