Placenta
Volume 31, Issue 10 , Pages 937-940 , October 2010

Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele

  • A. Markoff

      Affiliations

    • Institut für Medizinische Biochemie, ZMBE, WWU Münster, Von Esmarch Str. 56, 48149 Münster, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +492518352126; fax: +492518356748.
    • ,
  • S. Gerdes

      Affiliations

    • Institut für Medizinische Biochemie, ZMBE, WWU Münster, Von Esmarch Str. 56, 48149 Münster, Germany
    • ,
  • S. Feldner

      Affiliations

    • Institut für Humangenetik, WWU and UKM Münster, Germany
    • ,
  • N. Bogdanova

      Affiliations

    • Institut für Humangenetik, WWU and UKM Münster, Germany
    • ,
  • V. Gerke

      Affiliations

    • Institut für Medizinische Biochemie, ZMBE, WWU Münster, Von Esmarch Str. 56, 48149 Münster, Germany
    • ,
  • E. Grandone

      Affiliations

    • Atherosclerosis and Thrombosis Unit, I.R.C.C.S. “Casa Sollievo della Sofferenza”, Poliambulatorio Giovanni Paolo II, S. Giovanni Rotondo (FG), Italy

,Accepted 7 August 2010.

References 

  1. Gerke V, Creutz CE, Moss SE. . Annexins: linking Ca2+ signaling to membrane dynamics. Nat Rev Mol Cell Biol. 2005;6:449–461
  2. Thiagarajan P, Tait JF. Binding of annexin V/placental anticoagulant protein I to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. J Biol Chem. 1990;265:17420–17423
  3. Ravassa S, Bennaghmouch A, Kenis H, Lindhout T, Hackeng T, Narula J, et al. Annexin A5 down-regulates surface expression of tissue factor: a novel mechanism of regulating the membrane receptor repertoir. J Biol Chem. 2005;280:6028–6035
  4. Morgan RO, Bell DW, Testa JR, Fernandez MP. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. Genomics. 1998;48:100–110
  5. Carcedo MT, Iglesias JM, Bances P, Morgan RO, Fernandez MP. Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat regulate transcription. Biochem J. 2001;356:571–579
  6. Rand JH, Wu XX, Guller S, Gil J, Guha A, Scher J, et al. Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion. Am J Obstet Gynecol. 1994;171:1566–1572
  7. Shu F, Sugimura M, Kanayama N, Kobayashi H, Kobayashi T, Terao T. Immunohistochemical study of annexin V expression in placentae of preeclampsia. Gynecol Obstet Invest. 2000;49:17–23
  8. Bogdanova N, Horst J, Chlystun M, Croucher PJ, Nebel A, Bohring A, et al. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. Hum Mol Genet. 2007;16:573–578
  9. Chinni E, Tiscia GL, Colaizzo D, Vergura P, Margaglione M, Grandone E. Annexin V expression in human placenta is influenced by the carriership of the common haplotype M2. Fertil Steril. 2009;91:940–942
  10. Tiscia G, Colaizzo D, Chinni E, Pisanelli D, Sciannamè N, Favuzzi G, et al. Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications. Thromb Haemost. 2009;102:309–313
  11. Chinni E, Colaizzo D, Margaglione M, Rubini C, D’Ambrosio RL, Giuliani F, et al. Correlation between factors involved in the local haemostasis and angiogenesis in full term human placenta. Thromb Res. 2008;122:376–382
  12. Meller M, Vadachkoria S, Luthy DA, Williams MA. Evaluation of housekeeping genes in placental comparative expression studies. Placenta. 2005;26:601–607
  13. Bièche I, Onody P, Tozlu S, Driouch K, Vidaud M, Lidereau R. Prognostic value of ERBB family mRNA expression in breast carcinomas. Int J Cancer. 2003;106:758–765
  14. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–408
  15. Markoff A, Bogdanova N, Knop M, Rüffer C, Kenis H, Lux P, et al. Annexin A5 interacts with polycystin-1 and interferes with the polycystin-1 stimulated recruitment of E-cadherin into adherens junctions. J Mol Biol. 2007;369:954–966
  16. Sifakis S, Soufla G, Koukoura O, Soulitzis N, Koutroulakis D, Maiz N, et al. Decreased annexin A5 mRNA placental expression in pregnancies complicated by fetal growth restriction. Thromb Res. 2010;125:326–331

PII: S0143-4004(10)00297-3

doi: 10.1016/j.placenta.2010.08.002

Placenta
Volume 31, Issue 10 , Pages 937-940 , October 2010

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